Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
961
Gene name Gene Name - the full gene name approved by the HGNC.
CD47 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD47
Synonyms (NCBI Gene) Gene synonyms aliases
IAP, MER6, OA3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombo
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030709 hsa-miR-21-5p Microarray 18591254
MIRT040987 hsa-miR-505-3p CLASH 23622248
MIRT440977 hsa-miR-106b-5p HITS-CLIP 22473208
MIRT440976 hsa-miR-20a-5p HITS-CLIP 22473208
MIRT440977 hsa-miR-106b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15383453, 24026300, 25416956
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007229 Process Integrin-mediated signaling pathway TAS 8294396
GO:0008284 Process Positive regulation of cell population proliferation IDA 15383453
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601028 1682 ENSG00000196776
Protein
UniProt ID Q08722
Protein name Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
Protein function Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835,
PDB 2JJS , 2JJT , 2VSC , 4CMM , 4KJY , 5IWL , 5TZ2 , 5TZT , 5TZU , 7MYZ , 7WN8 , 7XJF , 7YGG , 8RP8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08204 V-set_CD47 8 142 CD47 immunoglobulin-like domain Domain
PF04549 CD47 144 292 CD47 transmembrane region Family
Tissue specificity TISSUE SPECIFICITY: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Macrophages (PubMed:39121194). {ECO:0000269|PubMed:39121194}.
Sequence
Sequence length 323
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Efferocytosis
ECM-receptor interaction
  Cell surface interactions at the vascular wall
Integrin cell surface interactions
Signal regulatory protein family interactions
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Bipolar Disorder Bipolar Disorder GWAS
Oligodendroglioma Oligodendroglioma GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acrocephalosyndactylia Associate 37118659
Acute Kidney Injury Associate 34698067
Adenocarcinoma of Lung Associate 35229723, 36823443
Adenomatous Polyposis Coli Associate 24073274
Anemia Associate 37063864
Anemia Dyserythropoietic Congenital Associate 27784127
Anemia Iron Deficiency Associate 36734715
Anemia Sickle Cell Associate 11264185, 18322255
Arterial Occlusive Diseases Associate 11264185
Arthritis Rheumatoid Inhibit 26355501