Gene Gene information from NCBI Gene database.
Entrez ID 961
Gene name CD47 molecule
Gene symbol CD47
Synonyms (NCBI Gene)
IAPMER6OA3
Chromosome 3
Chromosome location 3q13.12
Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombo
miRNA miRNA information provided by mirtarbase database.
619
miRTarBase ID miRNA Experiments Reference
MIRT030709 hsa-miR-21-5p Microarray 18591254
MIRT040987 hsa-miR-505-3p CLASH 23622248
MIRT440977 hsa-miR-106b-5p HITS-CLIP 22473208
MIRT440976 hsa-miR-20a-5p HITS-CLIP 22473208
MIRT440977 hsa-miR-106b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
50
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0002684 Process Positive regulation of immune system process IEA
GO:0005515 Function Protein binding IPI 8550562, 15383453, 15917238, 17070842, 19004835, 24026300, 25416956, 32296183, 32814053, 33961781
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601028 1682 ENSG00000196776
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q08722
Protein name Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
Protein function Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835,
PDB 2JJS , 2JJT , 2VSC , 4CMM , 4KJY , 5IWL , 5TZ2 , 5TZT , 5TZU , 7MYZ , 7WN8 , 7XJF , 7YGG , 8RP8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08204 V-set_CD47 8 142 CD47 immunoglobulin-like domain Domain
PF04549 CD47 144 292 CD47 transmembrane region Family
Tissue specificity TISSUE SPECIFICITY: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Macrophages (PubMed:39121194). {ECO:0000269|PubMed:39121194}.
Sequence
Sequence length 323
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Efferocytosis
ECM-receptor interaction
  Cell surface interactions at the vascular wall
Integrin cell surface interactions
Signal regulatory protein family interactions
Neutrophil degranulation