CARTPT (CART prepropeptide)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 9607
Gene name CART prepropeptide
Gene symbol CARTPT
Synonyms (NCBI Gene)
CART
Chromosome 5
Chromosome location 5q13.2
Summary This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expre
SNPs SNP information provided by dbSNP.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs121909065 G>C Risk-factor Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT863123 hsa-miR-1324 CLIP-seq
MIRT863124 hsa-miR-3163 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
REST Repression 18485095
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001678 Process Intracellular glucose homeostasis IDA 11711504
GO:0003674 Function Molecular_function ND
GO:0005184 Function Neuropeptide hormone activity IEA
GO:0005515 Function Protein binding IPI 21982860, 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
602606 24323 ENSG00000164326
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16568
Protein name Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)]
Protein function Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by lep
PDB 1HY9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06373 CART 47 → 116 Cocaine and amphetamine regulated transcript protein (CART) Family
Tissue specificity TISSUE SPECIFICITY: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.
Sequence
Sequence length 116
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Obesity Uncertain significance rs121909065 RCV000023199
Pheochromocytoma/paraganglioma syndrome 1 Uncertain significance rs121909065 RCV005859455
Show/Hide Text Mining Associations (65)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Mucinous Associate 32781417
Anxiety Associate 35476439
Aortic Aneurysm Thoracic Associate 37823268
Aortic Dissection Associate 37823268
Brain Edema Stimulate 35650594
Brain Neoplasms Associate 37343521
Breast Neoplasms Associate 22139072, 35115550, 37480115
Burkitt Lymphoma Associate 35222407
Calcinosis Cutis Inhibit 32527643
Chemical and Drug Induced Liver Injury Stimulate 23423337