Gene Gene information from NCBI Gene database.
Entrez ID 9604
Gene name Ring finger protein 14
Gene symbol RNF14
Synonyms (NCBI Gene)
ARA54HFB30HRIHFB2038TRIAD2
Chromosome 5
Chromosome location 5q31.3
Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in pros
miRNA miRNA information provided by mirtarbase database.
389
miRTarBase ID miRNA Experiments Reference
MIRT041839 hsa-miR-484 CLASH 23622248
MIRT644503 hsa-miR-4438 HITS-CLIP 23824327
MIRT644502 hsa-miR-6872-3p HITS-CLIP 23824327
MIRT644501 hsa-miR-4722-3p HITS-CLIP 23824327
MIRT644500 hsa-miR-6727-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IBA
GO:0003713 Function Transcription coactivator activity TAS 10085091
GO:0004842 Function Ubiquitin-protein transferase activity IEA
GO:0005515 Function Protein binding IPI 10085091, 19345326, 19549727, 25416956, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IDA 11322894
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605675 10058 ENSG00000013561
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UBS8
Protein name E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14)
Protein function E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05773 RWD 7 134 RWD domain Domain
PF01485 IBR 289 350 IBR domain, a half RING-finger domain Domain
PF01485 IBR 381 441 IBR domain, a half RING-finger domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10085091}.
Sequence
MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQN
SGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGS
VVLFAWMQFLKEET
LAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQE
EIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRH
VYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSL
DLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPC
KVTAEKLMDL
RNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKM
TCTGCMQYFCWICMGSLSRAN
PYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED
Sequence length 474
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Antigen processing: Ubiquitination & Proteasome degradation