PDIA4 (protein disulfide isomerase family A member 4)

Gene

• Entrez ID: 9601
• Gene name: Protein disulfide isomerase family A member 4
• Gene symbol: PDIA4
• Synonyms (NCBI Gene): ERP70, ERP72, ERp-72
• Chromosome: 7
• Chromosome location: 7q36.1
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalyticall

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018114	hsa-miR-335-5p	Microarray	18185580
MIRT049739	hsa-miR-92a-3p	CLASH	23622248
MIRT036839	hsa-miR-877-3p	CLASH	23622248
MIRT440013	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440013	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1221435	hsa-miR-1224-3p	CLIP-seq
MIRT1221436	hsa-miR-1260	CLIP-seq
MIRT1221437	hsa-miR-1260b	CLIP-seq
MIRT1221438	hsa-miR-1280	CLIP-seq
MIRT1221439	hsa-miR-1321	CLIP-seq
MIRT1221440	hsa-miR-186	CLIP-seq
MIRT1221441	hsa-miR-1909	CLIP-seq
MIRT1221442	hsa-miR-3121-3p	CLIP-seq
MIRT1221443	hsa-miR-3133	CLIP-seq
MIRT1221444	hsa-miR-3154	CLIP-seq
MIRT1221445	hsa-miR-3163	CLIP-seq
MIRT1221446	hsa-miR-3171	CLIP-seq
MIRT1221447	hsa-miR-346	CLIP-seq
MIRT1221448	hsa-miR-3591-3p	CLIP-seq
MIRT1221449	hsa-miR-3607-3p	CLIP-seq
MIRT1221450	hsa-miR-3616-5p	CLIP-seq
MIRT1221451	hsa-miR-3647-5p	CLIP-seq
MIRT1221452	hsa-miR-3686	CLIP-seq
MIRT1221453	hsa-miR-3713	CLIP-seq
MIRT1221454	hsa-miR-377	CLIP-seq
MIRT1221455	hsa-miR-378	CLIP-seq
MIRT1221456	hsa-miR-378b	CLIP-seq
MIRT1221457	hsa-miR-378c	CLIP-seq
MIRT1221458	hsa-miR-378d	CLIP-seq
MIRT1221459	hsa-miR-378e	CLIP-seq
MIRT1221460	hsa-miR-378f	CLIP-seq
MIRT1221461	hsa-miR-378h	CLIP-seq
MIRT1221462	hsa-miR-378i	CLIP-seq
MIRT1221463	hsa-miR-3973	CLIP-seq
MIRT1221464	hsa-miR-422a	CLIP-seq
MIRT1221465	hsa-miR-4270	CLIP-seq
MIRT1221466	hsa-miR-4441	CLIP-seq
MIRT1221467	hsa-miR-4638-3p	CLIP-seq
MIRT1221468	hsa-miR-4640-5p	CLIP-seq
MIRT1221469	hsa-miR-4686	CLIP-seq
MIRT1221470	hsa-miR-4704-3p	CLIP-seq
MIRT1221471	hsa-miR-4726-5p	CLIP-seq
MIRT1221472	hsa-miR-4739	CLIP-seq
MIRT1221473	hsa-miR-4756-5p	CLIP-seq
MIRT1221474	hsa-miR-4795-5p	CLIP-seq
MIRT1221475	hsa-miR-494	CLIP-seq
MIRT1221476	hsa-miR-5096	CLIP-seq
MIRT1221477	hsa-miR-532-3p	CLIP-seq
MIRT1221478	hsa-miR-539	CLIP-seq
MIRT1221479	hsa-miR-548c-3p	CLIP-seq
MIRT1221480	hsa-miR-548l	CLIP-seq
MIRT1221481	hsa-miR-570	CLIP-seq
MIRT1221482	hsa-miR-573	CLIP-seq
MIRT1221483	hsa-miR-576-3p	CLIP-seq
MIRT1221484	hsa-miR-580	CLIP-seq
MIRT1221485	hsa-miR-591	CLIP-seq
MIRT1221439	hsa-miR-1321	CLIP-seq
MIRT1221441	hsa-miR-1909	CLIP-seq
MIRT1221445	hsa-miR-3163	CLIP-seq
MIRT1221447	hsa-miR-346	CLIP-seq
MIRT1221448	hsa-miR-3591-3p	CLIP-seq
MIRT1221450	hsa-miR-3616-5p	CLIP-seq
MIRT1221451	hsa-miR-3647-5p	CLIP-seq
MIRT1221463	hsa-miR-3973	CLIP-seq
MIRT1221465	hsa-miR-4270	CLIP-seq
MIRT1221466	hsa-miR-4441	CLIP-seq
MIRT2063902	hsa-miR-4446-3p	CLIP-seq
MIRT2063903	hsa-miR-4660	CLIP-seq
MIRT1221470	hsa-miR-4704-3p	CLIP-seq
MIRT1221472	hsa-miR-4739	CLIP-seq
MIRT1221473	hsa-miR-4756-5p	CLIP-seq
MIRT1221474	hsa-miR-4795-5p	CLIP-seq
MIRT1221475	hsa-miR-494	CLIP-seq
MIRT1221480	hsa-miR-548l	CLIP-seq
MIRT1221482	hsa-miR-573	CLIP-seq
MIRT1221485	hsa-miR-591	CLIP-seq
MIRT2063904	hsa-miR-767-3p	CLIP-seq
MIRT2292397	hsa-miR-1225-3p	CLIP-seq
MIRT2292398	hsa-miR-1233	CLIP-seq
MIRT2292399	hsa-miR-3160-3p	CLIP-seq
MIRT1221450	hsa-miR-3616-5p	CLIP-seq
MIRT1221451	hsa-miR-3647-5p	CLIP-seq
MIRT2292400	hsa-miR-4254	CLIP-seq
MIRT2292401	hsa-miR-4287	CLIP-seq
MIRT2292402	hsa-miR-4292	CLIP-seq
MIRT2292403	hsa-miR-4308	CLIP-seq
MIRT2292404	hsa-miR-4469	CLIP-seq
MIRT2292405	hsa-miR-4633-3p	CLIP-seq
MIRT2292406	hsa-miR-4663	CLIP-seq
MIRT2292407	hsa-miR-4685-3p	CLIP-seq
MIRT2292408	hsa-miR-4757-5p	CLIP-seq
MIRT1221474	hsa-miR-4795-5p	CLIP-seq
MIRT1221475	hsa-miR-494	CLIP-seq
MIRT1221479	hsa-miR-548c-3p	CLIP-seq
MIRT1221482	hsa-miR-573	CLIP-seq
MIRT2392319	hsa-miR-2113	CLIP-seq
MIRT2392320	hsa-miR-218	CLIP-seq
MIRT2392321	hsa-miR-421	CLIP-seq
MIRT2392322	hsa-miR-4709-5p	CLIP-seq
MIRT2590481	hsa-miR-1207-5p	CLIP-seq
MIRT2292397	hsa-miR-1225-3p	CLIP-seq
MIRT2292398	hsa-miR-1233	CLIP-seq
MIRT2590482	hsa-miR-1275	CLIP-seq
MIRT2590483	hsa-miR-1276	CLIP-seq
MIRT2590484	hsa-miR-1293	CLIP-seq
MIRT2590485	hsa-miR-129-3p	CLIP-seq
MIRT1221439	hsa-miR-1321	CLIP-seq
MIRT2590486	hsa-miR-1324	CLIP-seq
MIRT1221441	hsa-miR-1909	CLIP-seq
MIRT2392319	hsa-miR-2113	CLIP-seq
MIRT2392320	hsa-miR-218	CLIP-seq
MIRT2590487	hsa-miR-3065-3p	CLIP-seq
MIRT2590488	hsa-miR-3121-5p	CLIP-seq
MIRT2590489	hsa-miR-3144-5p	CLIP-seq
MIRT2590490	hsa-miR-3148	CLIP-seq
MIRT2292399	hsa-miR-3160-3p	CLIP-seq
MIRT2590491	hsa-miR-331-3p	CLIP-seq
MIRT2590492	hsa-miR-361-3p	CLIP-seq
MIRT2590493	hsa-miR-3620	CLIP-seq
MIRT2590494	hsa-miR-3978	CLIP-seq
MIRT2392321	hsa-miR-421	CLIP-seq
MIRT2292400	hsa-miR-4254	CLIP-seq
MIRT1221465	hsa-miR-4270	CLIP-seq
MIRT2292401	hsa-miR-4287	CLIP-seq
MIRT2292402	hsa-miR-4292	CLIP-seq
MIRT2590495	hsa-miR-4293	CLIP-seq
MIRT2292403	hsa-miR-4308	CLIP-seq
MIRT2590496	hsa-miR-4313	CLIP-seq
MIRT2590497	hsa-miR-4330	CLIP-seq
MIRT1221466	hsa-miR-4441	CLIP-seq
MIRT2063902	hsa-miR-4446-3p	CLIP-seq
MIRT2292404	hsa-miR-4469	CLIP-seq
MIRT2590498	hsa-miR-4483	CLIP-seq
MIRT2590499	hsa-miR-4525	CLIP-seq
MIRT2292405	hsa-miR-4633-3p	CLIP-seq
MIRT2063903	hsa-miR-4660	CLIP-seq
MIRT2292406	hsa-miR-4663	CLIP-seq
MIRT2590500	hsa-miR-4665-5p	CLIP-seq
MIRT2292407	hsa-miR-4685-3p	CLIP-seq
MIRT2392322	hsa-miR-4709-5p	CLIP-seq
MIRT2590501	hsa-miR-4723-5p	CLIP-seq
MIRT2590502	hsa-miR-4725-5p	CLIP-seq
MIRT2590503	hsa-miR-4736	CLIP-seq
MIRT1221472	hsa-miR-4739	CLIP-seq
MIRT2590504	hsa-miR-4749-3p	CLIP-seq
MIRT1221473	hsa-miR-4756-5p	CLIP-seq
MIRT2292408	hsa-miR-4757-5p	CLIP-seq
MIRT2590505	hsa-miR-4762-5p	CLIP-seq
MIRT2590506	hsa-miR-4763-3p	CLIP-seq
MIRT2590507	hsa-miR-4786-3p	CLIP-seq
MIRT2590508	hsa-miR-4789-3p	CLIP-seq
MIRT1221475	hsa-miR-494	CLIP-seq
MIRT2590509	hsa-miR-504	CLIP-seq
MIRT2590510	hsa-miR-548p	CLIP-seq
MIRT2590511	hsa-miR-625	CLIP-seq
MIRT2590512	hsa-miR-637	CLIP-seq
MIRT2063904	hsa-miR-767-3p	CLIP-seq
MIRT2590513	hsa-miR-885-3p	CLIP-seq
MIRT2590481	hsa-miR-1207-5p	CLIP-seq
MIRT2292397	hsa-miR-1225-3p	CLIP-seq
MIRT2292398	hsa-miR-1233	CLIP-seq
MIRT2590482	hsa-miR-1275	CLIP-seq
MIRT2590483	hsa-miR-1276	CLIP-seq
MIRT2590484	hsa-miR-1293	CLIP-seq
MIRT2590485	hsa-miR-129-3p	CLIP-seq
MIRT1221439	hsa-miR-1321	CLIP-seq
MIRT2590486	hsa-miR-1324	CLIP-seq
MIRT1221441	hsa-miR-1909	CLIP-seq
MIRT2392319	hsa-miR-2113	CLIP-seq
MIRT2392320	hsa-miR-218	CLIP-seq
MIRT2590487	hsa-miR-3065-3p	CLIP-seq
MIRT2590488	hsa-miR-3121-5p	CLIP-seq
MIRT2590489	hsa-miR-3144-5p	CLIP-seq
MIRT2292399	hsa-miR-3160-3p	CLIP-seq
MIRT2590491	hsa-miR-331-3p	CLIP-seq
MIRT2590492	hsa-miR-361-3p	CLIP-seq
MIRT2590493	hsa-miR-3620	CLIP-seq
MIRT2392321	hsa-miR-421	CLIP-seq
MIRT2292400	hsa-miR-4254	CLIP-seq
MIRT1221465	hsa-miR-4270	CLIP-seq
MIRT2292401	hsa-miR-4287	CLIP-seq
MIRT2292402	hsa-miR-4292	CLIP-seq
MIRT2590495	hsa-miR-4293	CLIP-seq
MIRT2292403	hsa-miR-4308	CLIP-seq
MIRT2590496	hsa-miR-4313	CLIP-seq
MIRT2590497	hsa-miR-4330	CLIP-seq
MIRT1221466	hsa-miR-4441	CLIP-seq
MIRT2063902	hsa-miR-4446-3p	CLIP-seq
MIRT2292404	hsa-miR-4469	CLIP-seq
MIRT2590498	hsa-miR-4483	CLIP-seq
MIRT2590499	hsa-miR-4525	CLIP-seq
MIRT2292405	hsa-miR-4633-3p	CLIP-seq
MIRT2063903	hsa-miR-4660	CLIP-seq
MIRT2292406	hsa-miR-4663	CLIP-seq
MIRT2590500	hsa-miR-4665-5p	CLIP-seq
MIRT2292407	hsa-miR-4685-3p	CLIP-seq
MIRT2392322	hsa-miR-4709-5p	CLIP-seq
MIRT2590501	hsa-miR-4723-5p	CLIP-seq
MIRT2590502	hsa-miR-4725-5p	CLIP-seq
MIRT2590503	hsa-miR-4736	CLIP-seq
MIRT1221472	hsa-miR-4739	CLIP-seq
MIRT2590504	hsa-miR-4749-3p	CLIP-seq
MIRT1221473	hsa-miR-4756-5p	CLIP-seq
MIRT2292408	hsa-miR-4757-5p	CLIP-seq
MIRT2590505	hsa-miR-4762-5p	CLIP-seq
MIRT2590506	hsa-miR-4763-3p	CLIP-seq
MIRT2590507	hsa-miR-4786-3p	CLIP-seq
MIRT2590508	hsa-miR-4789-3p	CLIP-seq
MIRT1221475	hsa-miR-494	CLIP-seq
MIRT2590509	hsa-miR-504	CLIP-seq
MIRT2590510	hsa-miR-548p	CLIP-seq
MIRT2590511	hsa-miR-625	CLIP-seq
MIRT2590512	hsa-miR-637	CLIP-seq
MIRT2063904	hsa-miR-767-3p	CLIP-seq
MIRT2590513	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003756	Function	Protein disulfide isomerase activity	IBA
GO:0003756	Function	Protein disulfide isomerase activity	IEA
GO:0003756	Function	Protein disulfide isomerase activity	ISS
GO:0005515	Function	Protein binding	IPI	16287128, 22190034, 22665516, 23956175, 28514442, 30021884, 32296183, 33961781
GO:0005615	Component	Extracellular space	IDA	19995400
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS	2295602
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	ISS
GO:0009306	Process	Protein secretion	TAS	2295602
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	19995400
GO:0015035	Function	Protein-disulfide reductase activity	IDA	16677074
GO:0015035	Function	Protein-disulfide reductase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IBA
GO:0042470	Component	Melanosome	IEA

Other IDs

• MIM: 620018
• HGNC: 30167
• e!Ensembl: ENSG00000155660

Protein

• UniProt ID: P13667
• Protein name: Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
• PDB: 3IDV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00085	Thioredoxin	63 → 166	Thioredoxin	Domain
  PF00085	Thioredoxin	178 → 281	Thioredoxin	Domain
  PF13848	Thioredoxin_6	312 → 504		Domain
  PF00085	Thioredoxin	526 → 633	Thioredoxin	Domain

• Sequence:

  MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE
  ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI
  DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL
  VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE
  TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL
  KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP
  EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS
  VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD
  ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM
  DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF
  PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL

• Sequence length: 645

Pathways

KEGG:

Protein processing in endoplasmic reticulum
Thyroid hormone synthesis
Vibrio cholerae infection

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROTIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adenocarcinoma of Lung	Associate	24464223	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	36082822	★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	24464223	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	37432996	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	36404389	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	35634436	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	21743296	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	36814929	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	32023222	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Stimulate	22028783	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	31790472	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Associate	24464223	★☆☆☆☆ Found in Text Mining only
Myositis Inclusion Body	Associate	14695312	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	22028587	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	33159506, 35197484, 37720188	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Stimulate	29484832	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	35634436	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Stimulate	36082822	★☆☆☆☆ Found in Text Mining only