Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
960
Gene name Gene Name - the full gene name approved by the HGNC.
CD44 molecule (IN blood group)
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD44
Synonyms (NCBI Gene) Gene synonyms aliases
CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL, HUTCH-1, HUTCH-I, Hermes-1, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
LHR
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000989 hsa-miR-328-3p Luciferase reporter assay 18560585
MIRT000989 hsa-miR-328-3p Luciferase reporter assay 18560585
MIRT000989 hsa-miR-328-3p Luciferase reporter assay 18560585
MIRT000989 hsa-miR-328-3p Luciferase reporter assay 18560585
MIRT000989 hsa-miR-328-3p Luciferase reporter assay 18560585
Transcription factors
Transcription factor Regulation Reference
CTNNB1 Unknown 17724465
HDAC1 Repression 18372343
HMGA1 Activation 15901130
IKBKB Repression 18600306
MYCN Activation 19885598
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IBA 21873635
GO:0004896 Function Cytokine receptor activity IBA 21873635
GO:0004896 Function Cytokine receptor activity IDA 17045821
GO:0005515 Function Protein binding IPI 11207560, 20146103, 20549562, 20962267, 21397861, 23855374, 29190904
GO:0005518 Function Collagen binding NAS 2471973
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
107269 1681 ENSG00000026508
Protein
UniProt ID P16070
Protein name CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycop
Protein function Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby
PDB 1POZ , 1UUH , 2I83 , 4PZ3 , 4PZ4 , 6TXS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00193 Xlink 32 119 Extracellular link domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). Isoform 10 (epithelial isoform) is expressed by cells of epithelium an
Sequence
MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTL
PTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCF
N
ASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSS
GSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQE
TWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDD
EDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWN
PEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDS
HSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSIT
LQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDV
TGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNR
SLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLAL
ALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSET
PDQFMTADETRNLQNVDMKIGV
Sequence length 742
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  ECM-receptor interaction
Hematopoietic cell lineage
Shigellosis
Epstein-Barr virus infection
Proteoglycans in cancer
MicroRNAs in cancer
  Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation
Interferon gamma signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal neoplasms Hereditary Nonpolyposis Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
28255344
Colorectal cancer Hereditary Nonpolyposis Colorectal Cancer rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
28255344
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Multiple polyposis syndrome Adenomatous Polyposis Coli, Polyposis, Adenomatous Intestinal, Familial Intestinal Polyposis rs137854568, rs137854569, rs387906231, rs137854574, rs137854575, rs387906234, rs587776520, rs387906236, rs137854580, rs387906239, rs397515732, rs397515733, rs397515734, rs397515735, rs587779352
View all (85 more)
28255344
Unknown
Disease term Disease name Evidence References Source
Uterine Fibroids Uterine Fibroids GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Ischemic Stroke Ischemic Stroke GWAS
Associations from Text Mining
Disease Name Relationship Type References
Aberrant Crypt Foci Stimulate 38554332
Abortion Spontaneous Inhibit 24069351
Actinic cheilitis Associate 38126564
Adenocarcinoma Associate 10601048, 16884377, 16998464, 19596931, 26572077, 27285762, 29682524, 36643861, 7513984, 8567994, 9577373
Adenocarcinoma Inhibit 25335738
Adenocarcinoma Follicular Stimulate 9045959
Adenocarcinoma of Lung Associate 32344833, 36050791, 40657391
Adenoma Associate 18776587, 24619956, 34257584, 36631756, 7513984, 7534253, 8567994
Adenoma Stimulate 22562538, 9045959
Adenoma Pleomorphic Associate 23510689