Gene Gene information from NCBI Gene database.
Entrez ID 9589
Gene name WT1 associated protein
Gene symbol WTAP
Synonyms (NCBI Gene)
Mum2
Chromosome 6
Chromosome location 6q25.3
Summary The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 prote
miRNA miRNA information provided by mirtarbase database.
253
miRTarBase ID miRNA Experiments Reference
MIRT019716 hsa-miR-375 Microarray 20215506
MIRT022388 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT510557 hsa-miR-548n PAR-CLIP 20371350
MIRT510556 hsa-miR-548an PAR-CLIP 20371350
MIRT510555 hsa-miR-548l PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
WT1 Unknown 17095724
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IBA
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IEA
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IMP 24407421
GO:0005515 Function Protein binding IPI 15161933, 16189514, 24316715, 25416956, 28514442, 29507755, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605442 16846 ENSG00000146457
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15007
Protein name Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)
Protein function Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of
PDB 7VF2 , 7VF5 , 7YFJ , 7YG4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17098 Wtap 68 222 WTAP/Mum2p family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11001926}.
Sequence
MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEE
KLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLF
FLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRI
AQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTI
LVLQQQLKETRQQLAQYQ
QQQSQASAPSTSRTTASEPVEQSEATSKDCSRLTNGPSNGSSSRQRTSGSGFHREGNTTE
DDFPSSPGNGNKSSNSSEERTGRGGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSH
DPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGSVL
Sequence length 396
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Processing of Capped Intron-Containing Pre-mRNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ESOPHAGEAL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL ULCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Kidney Injury Associate 35569444
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 32398949, 36397411
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Inhibit 33725886
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 36541909
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Associate 40225569
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Associate 35211628
★☆☆☆☆
Found in Text Mining only
Brain Diseases Inhibit 32281240
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 34349094
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Stimulate 35046505
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 32814762, 32967010, 34999731, 38077434
★☆☆☆☆
Found in Text Mining only