Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9588
Gene name	Peroxiredoxin 6
Gene symbol	PRDX6
Synonyms (NCBI Gene)	1-CysAOP2HEL-S-128mLPCAT-5NSGPxPRXaiPLA2p29
Chromosome	1
Chromosome location	1q25.1
Summary	The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain org

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004940	hsa-miR-632	qRT-PCRWestern blot	17980029
MIRT044389	hsa-miR-320a	CLASH	23622248
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assayWestern blot	27484502
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assayWestern blot	27484502
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260576	hsa-miR-1178	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260578	hsa-miR-122	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT1260587	hsa-miR-137	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260589	hsa-miR-183	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260604	hsa-miR-3134	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260607	hsa-miR-3171	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT1260611	hsa-miR-342-3p	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260613	hsa-miR-361-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260615	hsa-miR-3679-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260619	hsa-miR-3714	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT1260623	hsa-miR-3921	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260625	hsa-miR-4252	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT1260631	hsa-miR-4493	CLIP-seq
MIRT1260632	hsa-miR-4502	CLIP-seq
MIRT1260633	hsa-miR-4530	CLIP-seq
MIRT1260634	hsa-miR-4534	CLIP-seq
MIRT1260635	hsa-miR-4653-5p	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260642	hsa-miR-4727-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260646	hsa-miR-4769-3p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260648	hsa-miR-4790-3p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260655	hsa-miR-512-3p	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT1260658	hsa-miR-518a-3p	CLIP-seq
MIRT1260659	hsa-miR-518b	CLIP-seq
MIRT1260660	hsa-miR-518c	CLIP-seq
MIRT1260661	hsa-miR-518d-3p	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260663	hsa-miR-518f	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT1260671	hsa-miR-607	CLIP-seq
MIRT1260672	hsa-miR-628-5p	CLIP-seq
MIRT1260673	hsa-miR-634	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT1260675	hsa-miR-759	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260678	hsa-miR-922	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT2303390	hsa-miR-142-5p	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT2303394	hsa-miR-3065-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT2303395	hsa-miR-340	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT2303396	hsa-miR-4494	CLIP-seq
MIRT2303397	hsa-miR-4499	CLIP-seq
MIRT2303398	hsa-miR-4506	CLIP-seq
MIRT2303399	hsa-miR-4517	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT2303401	hsa-miR-505	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303402	hsa-miR-617	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT2688556	hsa-miR-1305	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004601	Function	Peroxidase activity	IBA
GO:0004601	Function	Peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IMP	10893423
GO:0004623	Function	Phospholipase A2 activity	IDA	26830860
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005515	Function	Protein binding	IPI	16186110, 19188445, 20849852, 21044950, 21911577, 26030842, 29128334, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	16186110
GO:0005737	Component	Cytoplasm	IDA	16186110, 19188445, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	NAS	9497358
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IMP	10893423
GO:0016020	Component	Membrane	HDA	19946888
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016209	Function	Antioxidant activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19725078
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IMP	9587003
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045454	Process	Cell redox homeostasis	IBA
GO:0046475	Process	Glycerophospholipid catabolic process	IMP	10893423
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IDA	26830860
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IEA
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IMP	10893423
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IGI	16186110
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16186110
GO:0051920	Function	Peroxiredoxin activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0098869	Process	Cellular oxidant detoxification	IMP	10893423

MIM	HGNC	e!Ensembl
602316	16753	ENSG00000117592

P30041

Protein name

Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylch

Protein function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholip

PDB

1PRX , 5B6M , 5B6N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00578	AhpC-TSA	7 → 146	AhpC/TSA family	Domain
PF10417	1-cysPrx_C	166 → 205	C-terminal domain of 1-Cys peroxiredoxin	Domain

Sequence

MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

Sequence length

224

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolic pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs35052032	RCV005903270
Cervical cancer	Benign	rs35052032	RCV005903272
Colon adenocarcinoma	Uncertain significance	rs146176256	RCV005939418
Familial cancer of breast	Uncertain significance	rs146176256	RCV005939417
Gastric cancer	Benign	rs35052032	RCV005903274
Lung cancer	Benign	rs35052032	RCV005903277
Malignant tumor of esophagus	Benign	rs35052032	RCV005903271
Ovarian serous cystadenocarcinoma	Benign	rs35052032	RCV005903275
Sarcoma	Benign	rs35052032	RCV005903273
Thymoma	Benign	rs35052032	RCV005903276
Uterine corpus endometrial carcinoma	Benign	rs35052032	RCV005903278

Show/Hide Text Mining Associations (53)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	18474516
Acute Lung Injury	Associate	21627785, 35549905
Adenoma	Inhibit	19572226
Adenoma	Stimulate	30562740
Altitude Sickness	Associate	24265281
Aortic Aneurysm Abdominal	Stimulate	27934969
Brain Death	Inhibit	26647763
Brain Injuries Traumatic	Inhibit	29717219
Breast Neoplasms	Associate	1720785, 31839604, 37268731
Carcinogenesis	Associate	19893992, 34517184
Carcinoma Hepatocellular	Associate	19893992, 35318110
Carcinoma Non Small Cell Lung	Associate	34517184
Cerebral Infarction	Associate	38287382
Chemical and Drug Induced Liver Injury	Inhibit	26647763
Cholangiocarcinoma	Associate	34320944
Colonic Neoplasms	Associate	34761597
Colorectal Neoplasms	Associate	30562740
Dementia	Associate	12213717
Diabetic Nephropathies	Associate	36466094, 37554330
Drug Related Side Effects and Adverse Reactions	Associate	34517184
Dyskeratosis Congenita	Associate	29055871
Endometrial Neoplasms	Associate	22415234
Epilepsy Tonic Clonic	Associate	21627785
Genetic Diseases Inborn	Associate	26279427
Hypoxia	Stimulate	24265281
Hypoxia	Inhibit	26647763
Infertility	Associate	29912414
Inflammation	Associate	35549905
Intrahepatic Cholestasis of Pregnancy	Associate	24391750
Ischemia	Inhibit	26647763
Lewy Body Disease	Associate	12213717
Lung Neoplasms	Associate	19937138
Malformations of Cortical Development	Associate	28222113
Mental Disorders	Associate	23272063
Neoplasm Metastasis	Associate	23217164
Neoplasm Metastasis	Stimulate	30562740
Neoplasms	Associate	20829884, 23217164, 30639960, 30756364, 31640461, 34517184, 34761597, 35645108
Neuroinflammatory Diseases	Associate	38287382
Oligodendroglioma	Associate	17653765
Osteoarthritis	Associate	23937207
Osteoglophonic dwarfism	Associate	38287382
Ovarian Neoplasms	Associate	30104402
Parkinson Disease	Stimulate	12213717
Pick Disease of the Brain	Associate	21769920
Prostatic Neoplasms	Associate	21031435, 21796653, 27197287
Pulmonary Disease Chronic Obstructive	Associate	37329238
Schizophrenia	Associate	19405953
Squamous Cell Carcinoma of Head and Neck	Associate	24386210, 31517839, 34853622
Stomach Diseases	Associate	27743162
Stomach Neoplasms	Associate	20829884
Stomach Neoplasms	Stimulate	35645108
Visceral myopathy familial external ophthalmoplegia	Associate	34070501
Wounds and Injuries	Associate	21627785

PRDX6 (peroxiredoxin 6)