APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9582
Gene name Gene Name - the full gene name approved by the HGNC.
Apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
APOBEC3B
Synonyms (NCBI Gene) Gene synonyms aliases
A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and fu
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT016537 hsa-miR-193b-3p Microarray 20304954
MIRT756221 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Immunoprecipitaion (IP) 34704004
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IBA 21873635
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IBA 21873635
GO:0004126 Function Cytidine deaminase activity IBA 21873635
GO:0005515 Function Protein binding IPI 31217276
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607110 17352 ENSG00000179750
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9UH17
Protein name DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)
Protein function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infe
PDB 2NBQ , 5CQD , 5CQH , 5CQI , 5CQK , 5SXG , 5SXH , 5TD5 , 5TKM , 6NFK , 6NFL , 6NFM , 7RW6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18782 NAD2 10 → 189 Family
PF05240 APOBEC_C 301 → 377 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}.
Sequence
Sequence length 382
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Viral life cycle - HIV-1
Human immunodeficiency virus 1 infection 		  mRNA Editing: C to U Conversion
Formation of the Editosome
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (6)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)		 23852168, 27643540, 23389445, 24728294
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)		 27643540, 24728294, 23852168, 23389445
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 23852168
Cervical cancer cervical cancer rs28934571, rs121913482, rs121913483 23852168
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Head and neck cancer Malignant Head and Neck Neoplasm 23852168 ClinVar
Show/Hide Text Mining Associations (70)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 19698078
Acute Retroviral Syndrome Inhibit 21715505
Adenocarcinoma of Lung Associate 25401976, 30840888
Alcoholism Associate 21995620
Asthma Associate 30697902, 37301411
Breast Neoplasms Associate 21276136, 23389445, 23598277, 23715497, 23852168, 23985681, 24728294, 24858917, 25123150, 25538195, 25730878, 26320772, 26411678, 26682542, 26920143
View all (21 more)
Breast Neoplasms Stimulate 31217276
Carcinogenesis Associate 23150777, 25502777, 27147740, 27233495, 27485054, 28077648, 32632179, 33592502
Carcinoma Hepatocellular Associate 26760979, 27310677, 31322199, 32880638, 37903974
Carcinoma Merkel Cell Associate 34968501