Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9580
Gene name Gene Name - the full gene name approved by the HGNC.
SRY-box transcription factor 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SOX13
Synonyms (NCBI Gene) Gene synonyms aliases
ICA12, Sox-13
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016882 hsa-miR-335-5p Microarray 18185580
MIRT052343 hsa-let-7b-5p CLASH 23622248
MIRT734063 hsa-let-7c-3p Immunohistochemistry (IHC), Microarray, qRT-PCR 33424970
MIRT734064 hsa-miR-135b-3p Immunohistochemistry (IHC), Microarray, qRT-PCR 33424970
MIRT1380330 hsa-miR-1225-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20028982
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 26525805
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604748 11192 ENSG00000143842
Protein
UniProt ID Q9UN79
Protein name Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)
Protein function Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the d
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00505 HMG_box 424 492 HMG (high mobility group) box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level) (PubMed:10871192). Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver (PubMed:10871192, PubMed:20028982). Expressed in adip
Sequence
MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSAD
PQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLS
SDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAML
FEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLP
VTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPK
APELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQL
LHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRN
SSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARL
SRQHLEKYPDYK
YKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMS
SSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYR
YSEDEDSEGEEKSDGELVVLTD
Sequence length 622
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Deactivation of the beta-catenin transactivating complex