Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9578
Gene name Gene Name - the full gene name approved by the HGNC.	CDC42 binding protein kinase beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CDC42BPB
Synonyms (NCBI Gene) Gene synonyms aliases	CHOCNS, MRCKB
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q32.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dyst

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1016320330	G>C,T	Likely-pathogenic	Synonymous variant, coding sequence variant, non coding transcript variant, missense variant
rs1198710710	C>T	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs1595127294	C>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595208914	CGTCCAGGAGCAGC>-	Likely-pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1595450125	C>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595450393	C>T	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595472739	C>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595472741	G>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595472756	A>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595472764	G>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1595476797	G>A	Likely-pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1595482918	->C	Likely-pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020532	hsa-miR-155-5p	Proteomics	18668040
MIRT023484	hsa-miR-1-3p	Proteomics	18668040
MIRT877829	hsa-miR-1207-5p	CLIP-seq
MIRT877830	hsa-miR-1225-5p	CLIP-seq
MIRT877831	hsa-miR-1250	CLIP-seq
MIRT877832	hsa-miR-1271	CLIP-seq
MIRT877833	hsa-miR-128	CLIP-seq
MIRT877834	hsa-miR-1283	CLIP-seq
MIRT877835	hsa-miR-1286	CLIP-seq
MIRT877836	hsa-miR-136	CLIP-seq
MIRT877837	hsa-miR-141	CLIP-seq
MIRT877838	hsa-miR-148a	CLIP-seq
MIRT877839	hsa-miR-148b	CLIP-seq
MIRT877840	hsa-miR-152	CLIP-seq
MIRT877841	hsa-miR-155	CLIP-seq
MIRT877842	hsa-miR-1827	CLIP-seq
MIRT877843	hsa-miR-183	CLIP-seq
MIRT877844	hsa-miR-1912	CLIP-seq
MIRT877845	hsa-miR-193a-5p	CLIP-seq
MIRT877846	hsa-miR-199a-3p	CLIP-seq
MIRT877847	hsa-miR-199b-3p	CLIP-seq
MIRT877848	hsa-miR-19a	CLIP-seq
MIRT877849	hsa-miR-19b	CLIP-seq
MIRT877850	hsa-miR-200a	CLIP-seq
MIRT877851	hsa-miR-205	CLIP-seq
MIRT877852	hsa-miR-2110	CLIP-seq
MIRT877853	hsa-miR-2355-5p	CLIP-seq
MIRT877854	hsa-miR-2467-5p	CLIP-seq
MIRT877855	hsa-miR-27a	CLIP-seq
MIRT877856	hsa-miR-27b	CLIP-seq
MIRT877857	hsa-miR-298	CLIP-seq
MIRT877858	hsa-miR-3117-5p	CLIP-seq
MIRT877859	hsa-miR-3129-5p	CLIP-seq
MIRT877860	hsa-miR-3135b	CLIP-seq
MIRT877861	hsa-miR-3140-5p	CLIP-seq
MIRT877862	hsa-miR-3148	CLIP-seq
MIRT877863	hsa-miR-3150a-3p	CLIP-seq
MIRT877864	hsa-miR-3169	CLIP-seq
MIRT877865	hsa-miR-3188	CLIP-seq
MIRT877866	hsa-miR-3189-3p	CLIP-seq
MIRT877867	hsa-miR-3190	CLIP-seq
MIRT877868	hsa-miR-323-3p	CLIP-seq
MIRT877869	hsa-miR-323b-5p	CLIP-seq
MIRT877870	hsa-miR-338-3p	CLIP-seq
MIRT877871	hsa-miR-342-5p	CLIP-seq
MIRT877872	hsa-miR-34a	CLIP-seq
MIRT877873	hsa-miR-34b	CLIP-seq
MIRT877874	hsa-miR-34c-5p	CLIP-seq
MIRT877875	hsa-miR-3607-5p	CLIP-seq
MIRT877876	hsa-miR-3609	CLIP-seq
MIRT877877	hsa-miR-3612	CLIP-seq
MIRT877878	hsa-miR-361-3p	CLIP-seq
MIRT877879	hsa-miR-3616-3p	CLIP-seq
MIRT877880	hsa-miR-3646	CLIP-seq
MIRT877881	hsa-miR-3657	CLIP-seq
MIRT877882	hsa-miR-3672	CLIP-seq
MIRT877883	hsa-miR-3675-5p	CLIP-seq
MIRT877884	hsa-miR-3688-3p	CLIP-seq
MIRT877885	hsa-miR-369-3p	CLIP-seq
MIRT877886	hsa-miR-371-3p	CLIP-seq
MIRT877887	hsa-miR-374a	CLIP-seq
MIRT877888	hsa-miR-374b	CLIP-seq
MIRT877889	hsa-miR-3915	CLIP-seq
MIRT877890	hsa-miR-3928	CLIP-seq
MIRT877891	hsa-miR-3935	CLIP-seq
MIRT877892	hsa-miR-3944-5p	CLIP-seq
MIRT877893	hsa-miR-3975	CLIP-seq
MIRT877894	hsa-miR-411	CLIP-seq
MIRT877895	hsa-miR-4264	CLIP-seq
MIRT877896	hsa-miR-4271	CLIP-seq
MIRT877897	hsa-miR-4283	CLIP-seq
MIRT877898	hsa-miR-4436b-3p	CLIP-seq
MIRT877899	hsa-miR-4459	CLIP-seq
MIRT877900	hsa-miR-4463	CLIP-seq
MIRT877901	hsa-miR-4480	CLIP-seq
MIRT877902	hsa-miR-4493	CLIP-seq
MIRT877903	hsa-miR-449a	CLIP-seq
MIRT877904	hsa-miR-449b	CLIP-seq
MIRT877905	hsa-miR-4515	CLIP-seq
MIRT877906	hsa-miR-4520a-3p	CLIP-seq
MIRT877907	hsa-miR-4520b-3p	CLIP-seq
MIRT877908	hsa-miR-4530	CLIP-seq
MIRT877909	hsa-miR-4640-5p	CLIP-seq
MIRT877910	hsa-miR-4641	CLIP-seq
MIRT877911	hsa-miR-4646-5p	CLIP-seq
MIRT877912	hsa-miR-4649-3p	CLIP-seq
MIRT877913	hsa-miR-4651	CLIP-seq
MIRT877914	hsa-miR-4663	CLIP-seq
MIRT877915	hsa-miR-4664-5p	CLIP-seq
MIRT877916	hsa-miR-4668-5p	CLIP-seq
MIRT877917	hsa-miR-4669	CLIP-seq
MIRT877918	hsa-miR-4694-5p	CLIP-seq
MIRT877919	hsa-miR-4695-5p	CLIP-seq
MIRT877920	hsa-miR-4706	CLIP-seq
MIRT877921	hsa-miR-4722-5p	CLIP-seq
MIRT877922	hsa-miR-4725-3p	CLIP-seq
MIRT877923	hsa-miR-4726-3p	CLIP-seq
MIRT877924	hsa-miR-4726-5p	CLIP-seq
MIRT877925	hsa-miR-4731-5p	CLIP-seq
MIRT877926	hsa-miR-4736	CLIP-seq
MIRT877927	hsa-miR-4746-3p	CLIP-seq
MIRT877928	hsa-miR-4749-5p	CLIP-seq
MIRT877929	hsa-miR-4763-3p	CLIP-seq
MIRT877930	hsa-miR-4778-3p	CLIP-seq
MIRT877931	hsa-miR-4779	CLIP-seq
MIRT877932	hsa-miR-4795-5p	CLIP-seq
MIRT877933	hsa-miR-485-5p	CLIP-seq
MIRT877934	hsa-miR-486-3p	CLIP-seq
MIRT877935	hsa-miR-487a	CLIP-seq
MIRT877936	hsa-miR-502-5p	CLIP-seq
MIRT877937	hsa-miR-511	CLIP-seq
MIRT877938	hsa-miR-513a-5p	CLIP-seq
MIRT877939	hsa-miR-519a	CLIP-seq
MIRT877940	hsa-miR-519b-3p	CLIP-seq
MIRT877941	hsa-miR-519c-3p	CLIP-seq
MIRT877942	hsa-miR-520d-5p	CLIP-seq
MIRT877943	hsa-miR-520g	CLIP-seq
MIRT877944	hsa-miR-520h	CLIP-seq
MIRT877945	hsa-miR-524-5p	CLIP-seq
MIRT877946	hsa-miR-544	CLIP-seq
MIRT877947	hsa-miR-548a-5p	CLIP-seq
MIRT877948	hsa-miR-548aa	CLIP-seq
MIRT877949	hsa-miR-548ab	CLIP-seq
MIRT877950	hsa-miR-548ac	CLIP-seq
MIRT877951	hsa-miR-548ae	CLIP-seq
MIRT877952	hsa-miR-548ah	CLIP-seq
MIRT877953	hsa-miR-548aj	CLIP-seq
MIRT877954	hsa-miR-548ak	CLIP-seq
MIRT877955	hsa-miR-548am	CLIP-seq
MIRT877956	hsa-miR-548b-5p	CLIP-seq
MIRT877957	hsa-miR-548c-5p	CLIP-seq
MIRT877958	hsa-miR-548d-3p	CLIP-seq
MIRT877959	hsa-miR-548d-5p	CLIP-seq
MIRT877960	hsa-miR-548h	CLIP-seq
MIRT877961	hsa-miR-548i	CLIP-seq
MIRT877962	hsa-miR-548j	CLIP-seq
MIRT877963	hsa-miR-548n	CLIP-seq
MIRT877964	hsa-miR-548u	CLIP-seq
MIRT877965	hsa-miR-548w	CLIP-seq
MIRT877966	hsa-miR-548x	CLIP-seq
MIRT877967	hsa-miR-548y	CLIP-seq
MIRT877968	hsa-miR-548z	CLIP-seq
MIRT877969	hsa-miR-551a	CLIP-seq
MIRT877970	hsa-miR-551b	CLIP-seq
MIRT877971	hsa-miR-559	CLIP-seq
MIRT877972	hsa-miR-570	CLIP-seq
MIRT877973	hsa-miR-604	CLIP-seq
MIRT877974	hsa-miR-608	CLIP-seq
MIRT877975	hsa-miR-615-5p	CLIP-seq
MIRT877976	hsa-miR-617	CLIP-seq
MIRT877977	hsa-miR-622	CLIP-seq
MIRT877978	hsa-miR-647	CLIP-seq
MIRT877979	hsa-miR-650	CLIP-seq
MIRT877980	hsa-miR-656	CLIP-seq
MIRT877981	hsa-miR-665	CLIP-seq
MIRT877982	hsa-miR-671-5p	CLIP-seq
MIRT877983	hsa-miR-744	CLIP-seq
MIRT877984	hsa-miR-764	CLIP-seq
MIRT877985	hsa-miR-873	CLIP-seq
MIRT877986	hsa-miR-922	CLIP-seq
MIRT877987	hsa-miR-96	CLIP-seq
MIRT1546315	hsa-miR-3180	CLIP-seq
MIRT1546316	hsa-miR-3180-3p	CLIP-seq
MIRT1546317	hsa-miR-3196	CLIP-seq
MIRT1546318	hsa-miR-4447	CLIP-seq
MIRT1546319	hsa-miR-4456	CLIP-seq
MIRT1546320	hsa-miR-4472	CLIP-seq
MIRT1546321	hsa-miR-4488	CLIP-seq
MIRT1546322	hsa-miR-4697-5p	CLIP-seq
MIRT1546323	hsa-miR-541	CLIP-seq
MIRT1546324	hsa-miR-654-5p	CLIP-seq
MIRT877887	hsa-miR-374a	CLIP-seq
MIRT877888	hsa-miR-374b	CLIP-seq
MIRT877980	hsa-miR-656	CLIP-seq
MIRT1960137	hsa-miR-1184	CLIP-seq
MIRT1960138	hsa-miR-1205	CLIP-seq
MIRT877829	hsa-miR-1207-5p	CLIP-seq
MIRT1960139	hsa-miR-122	CLIP-seq
MIRT877830	hsa-miR-1225-5p	CLIP-seq
MIRT877831	hsa-miR-1250	CLIP-seq
MIRT1960140	hsa-miR-1262	CLIP-seq
MIRT877833	hsa-miR-128	CLIP-seq
MIRT877834	hsa-miR-1283	CLIP-seq
MIRT877835	hsa-miR-1286	CLIP-seq
MIRT1960141	hsa-miR-1293	CLIP-seq
MIRT1960142	hsa-miR-1301	CLIP-seq
MIRT1960143	hsa-miR-1343	CLIP-seq
MIRT877836	hsa-miR-136	CLIP-seq
MIRT877838	hsa-miR-148a	CLIP-seq
MIRT877839	hsa-miR-148b	CLIP-seq
MIRT877840	hsa-miR-152	CLIP-seq
MIRT877841	hsa-miR-155	CLIP-seq
MIRT877842	hsa-miR-1827	CLIP-seq
MIRT877843	hsa-miR-183	CLIP-seq
MIRT1960144	hsa-miR-1909	CLIP-seq
MIRT877844	hsa-miR-1912	CLIP-seq
MIRT877845	hsa-miR-193a-5p	CLIP-seq
MIRT1960145	hsa-miR-1972	CLIP-seq
MIRT877846	hsa-miR-199a-3p	CLIP-seq
MIRT1960146	hsa-miR-199a-5p	CLIP-seq
MIRT877847	hsa-miR-199b-3p	CLIP-seq
MIRT1960147	hsa-miR-199b-5p	CLIP-seq
MIRT877852	hsa-miR-2110	CLIP-seq
MIRT1960148	hsa-miR-2115	CLIP-seq
MIRT1960149	hsa-miR-214	CLIP-seq
MIRT1960150	hsa-miR-2355-3p	CLIP-seq
MIRT877853	hsa-miR-2355-5p	CLIP-seq
MIRT877855	hsa-miR-27a	CLIP-seq
MIRT877856	hsa-miR-27b	CLIP-seq
MIRT1960151	hsa-miR-2861	CLIP-seq
MIRT1960152	hsa-miR-296-5p	CLIP-seq
MIRT877857	hsa-miR-298	CLIP-seq
MIRT877858	hsa-miR-3117-5p	CLIP-seq
MIRT877859	hsa-miR-3129-5p	CLIP-seq
MIRT1960153	hsa-miR-3130-3p	CLIP-seq
MIRT877860	hsa-miR-3135b	CLIP-seq
MIRT1960154	hsa-miR-3136-3p	CLIP-seq
MIRT1960155	hsa-miR-3138	CLIP-seq
MIRT877861	hsa-miR-3140-5p	CLIP-seq
MIRT1960156	hsa-miR-3147	CLIP-seq
MIRT877862	hsa-miR-3148	CLIP-seq
MIRT877863	hsa-miR-3150a-3p	CLIP-seq
MIRT1960157	hsa-miR-3158-5p	CLIP-seq
MIRT1960158	hsa-miR-3166	CLIP-seq
MIRT1546315	hsa-miR-3180	CLIP-seq
MIRT1546316	hsa-miR-3180-3p	CLIP-seq
MIRT1960159	hsa-miR-3189-5p	CLIP-seq
MIRT877867	hsa-miR-3190	CLIP-seq
MIRT1546317	hsa-miR-3196	CLIP-seq
MIRT1960160	hsa-miR-323-5p	CLIP-seq
MIRT877869	hsa-miR-323b-5p	CLIP-seq
MIRT877871	hsa-miR-342-5p	CLIP-seq
MIRT1960161	hsa-miR-346	CLIP-seq
MIRT877872	hsa-miR-34a	CLIP-seq
MIRT877873	hsa-miR-34b	CLIP-seq
MIRT877874	hsa-miR-34c-5p	CLIP-seq
MIRT877875	hsa-miR-3607-5p	CLIP-seq
MIRT877876	hsa-miR-3609	CLIP-seq
MIRT877877	hsa-miR-3612	CLIP-seq
MIRT877878	hsa-miR-361-3p	CLIP-seq
MIRT1960162	hsa-miR-3615	CLIP-seq
MIRT1960163	hsa-miR-3619-5p	CLIP-seq
MIRT877884	hsa-miR-3688-3p	CLIP-seq
MIRT877886	hsa-miR-371-3p	CLIP-seq
MIRT877889	hsa-miR-3915	CLIP-seq
MIRT1960164	hsa-miR-3918	CLIP-seq
MIRT1960165	hsa-miR-3925-3p	CLIP-seq
MIRT877890	hsa-miR-3928	CLIP-seq
MIRT877891	hsa-miR-3935	CLIP-seq
MIRT1960166	hsa-miR-3939	CLIP-seq
MIRT877892	hsa-miR-3944-5p	CLIP-seq
MIRT1960167	hsa-miR-3974	CLIP-seq
MIRT877894	hsa-miR-411	CLIP-seq
MIRT1960168	hsa-miR-4267	CLIP-seq
MIRT877896	hsa-miR-4271	CLIP-seq
MIRT877897	hsa-miR-4283	CLIP-seq
MIRT1960169	hsa-miR-4288	CLIP-seq
MIRT1960170	hsa-miR-4290	CLIP-seq
MIRT1960171	hsa-miR-4291	CLIP-seq
MIRT1960172	hsa-miR-4299	CLIP-seq
MIRT1960173	hsa-miR-4302	CLIP-seq
MIRT1960174	hsa-miR-4425	CLIP-seq
MIRT1960175	hsa-miR-4433	CLIP-seq
MIRT1960176	hsa-miR-4443	CLIP-seq
MIRT1546318	hsa-miR-4447	CLIP-seq
MIRT1960177	hsa-miR-4450	CLIP-seq
MIRT877899	hsa-miR-4459	CLIP-seq
MIRT877900	hsa-miR-4463	CLIP-seq
MIRT1546320	hsa-miR-4472	CLIP-seq
MIRT1960178	hsa-miR-4483	CLIP-seq
MIRT1960179	hsa-miR-4487	CLIP-seq
MIRT1546321	hsa-miR-4488	CLIP-seq
MIRT1960180	hsa-miR-4496	CLIP-seq
MIRT877903	hsa-miR-449a	CLIP-seq
MIRT877904	hsa-miR-449b	CLIP-seq
MIRT1960181	hsa-miR-4512	CLIP-seq
MIRT877905	hsa-miR-4515	CLIP-seq
MIRT1960182	hsa-miR-4529-5p	CLIP-seq
MIRT877908	hsa-miR-4530	CLIP-seq
MIRT1960183	hsa-miR-4632	CLIP-seq
MIRT877909	hsa-miR-4640-5p	CLIP-seq
MIRT877910	hsa-miR-4641	CLIP-seq
MIRT1960184	hsa-miR-4646-3p	CLIP-seq
MIRT877911	hsa-miR-4646-5p	CLIP-seq
MIRT877913	hsa-miR-4651	CLIP-seq
MIRT1960185	hsa-miR-4660	CLIP-seq
MIRT877914	hsa-miR-4663	CLIP-seq
MIRT877915	hsa-miR-4664-5p	CLIP-seq
MIRT877916	hsa-miR-4668-5p	CLIP-seq
MIRT1960186	hsa-miR-4671-5p	CLIP-seq
MIRT1960187	hsa-miR-4690-3p	CLIP-seq
MIRT1960188	hsa-miR-4690-5p	CLIP-seq
MIRT877918	hsa-miR-4694-5p	CLIP-seq
MIRT877919	hsa-miR-4695-5p	CLIP-seq
MIRT1546322	hsa-miR-4697-5p	CLIP-seq
MIRT1960189	hsa-miR-4701-3p	CLIP-seq
MIRT877920	hsa-miR-4706	CLIP-seq
MIRT1960190	hsa-miR-4711-3p	CLIP-seq
MIRT1960191	hsa-miR-4717-5p	CLIP-seq
MIRT877921	hsa-miR-4722-5p	CLIP-seq
MIRT877922	hsa-miR-4725-3p	CLIP-seq
MIRT877923	hsa-miR-4726-3p	CLIP-seq
MIRT877924	hsa-miR-4726-5p	CLIP-seq
MIRT877925	hsa-miR-4731-5p	CLIP-seq
MIRT877926	hsa-miR-4736	CLIP-seq
MIRT877927	hsa-miR-4746-3p	CLIP-seq
MIRT877928	hsa-miR-4749-5p	CLIP-seq
MIRT1960192	hsa-miR-4753-3p	CLIP-seq
MIRT877929	hsa-miR-4763-3p	CLIP-seq
MIRT1960193	hsa-miR-4763-5p	CLIP-seq
MIRT1960194	hsa-miR-4771	CLIP-seq
MIRT877930	hsa-miR-4778-3p	CLIP-seq
MIRT877932	hsa-miR-4795-5p	CLIP-seq
MIRT1960195	hsa-miR-4800-5p	CLIP-seq
MIRT877934	hsa-miR-486-3p	CLIP-seq
MIRT877935	hsa-miR-487a	CLIP-seq
MIRT1960196	hsa-miR-5047	CLIP-seq
MIRT877937	hsa-miR-511	CLIP-seq
MIRT877938	hsa-miR-513a-5p	CLIP-seq
MIRT1960197	hsa-miR-516a-3p	CLIP-seq
MIRT877939	hsa-miR-519a	CLIP-seq
MIRT877940	hsa-miR-519b-3p	CLIP-seq
MIRT877941	hsa-miR-519c-3p	CLIP-seq
MIRT877942	hsa-miR-520d-5p	CLIP-seq
MIRT877943	hsa-miR-520g	CLIP-seq
MIRT877944	hsa-miR-520h	CLIP-seq
MIRT877945	hsa-miR-524-5p	CLIP-seq
MIRT877946	hsa-miR-544	CLIP-seq
MIRT1960198	hsa-miR-548a-3p	CLIP-seq
MIRT877952	hsa-miR-548ah	CLIP-seq
MIRT1960199	hsa-miR-548e	CLIP-seq
MIRT1960200	hsa-miR-548f	CLIP-seq
MIRT877964	hsa-miR-548u	CLIP-seq
MIRT877969	hsa-miR-551a	CLIP-seq
MIRT877970	hsa-miR-551b	CLIP-seq
MIRT1960201	hsa-miR-561	CLIP-seq
MIRT877972	hsa-miR-570	CLIP-seq
MIRT1960202	hsa-miR-574-5p	CLIP-seq
MIRT1960203	hsa-miR-576-3p	CLIP-seq
MIRT1960204	hsa-miR-597	CLIP-seq
MIRT1960205	hsa-miR-601	CLIP-seq
MIRT877973	hsa-miR-604	CLIP-seq
MIRT877974	hsa-miR-608	CLIP-seq
MIRT877976	hsa-miR-617	CLIP-seq
MIRT1960206	hsa-miR-632	CLIP-seq
MIRT1960207	hsa-miR-642a	CLIP-seq
MIRT877978	hsa-miR-647	CLIP-seq
MIRT1960208	hsa-miR-648	CLIP-seq
MIRT877979	hsa-miR-650	CLIP-seq
MIRT1960209	hsa-miR-654-3p	CLIP-seq
MIRT1960210	hsa-miR-668	CLIP-seq
MIRT877982	hsa-miR-671-5p	CLIP-seq
MIRT1960211	hsa-miR-720	CLIP-seq
MIRT877983	hsa-miR-744	CLIP-seq
MIRT1960212	hsa-miR-761	CLIP-seq
MIRT877984	hsa-miR-764	CLIP-seq
MIRT1960213	hsa-miR-766	CLIP-seq
MIRT1960214	hsa-miR-767-5p	CLIP-seq
MIRT877985	hsa-miR-873	CLIP-seq
MIRT877986	hsa-miR-922	CLIP-seq
MIRT1960215	hsa-miR-934	CLIP-seq
MIRT1960216	hsa-miR-943	CLIP-seq
MIRT1960137	hsa-miR-1184	CLIP-seq
MIRT1960138	hsa-miR-1205	CLIP-seq
MIRT877829	hsa-miR-1207-5p	CLIP-seq
MIRT877830	hsa-miR-1225-5p	CLIP-seq
MIRT877831	hsa-miR-1250	CLIP-seq
MIRT877832	hsa-miR-1271	CLIP-seq
MIRT2197047	hsa-miR-1281	CLIP-seq
MIRT877834	hsa-miR-1283	CLIP-seq
MIRT877835	hsa-miR-1286	CLIP-seq
MIRT2197048	hsa-miR-1294	CLIP-seq
MIRT1960142	hsa-miR-1301	CLIP-seq
MIRT877837	hsa-miR-141	CLIP-seq
MIRT877838	hsa-miR-148a	CLIP-seq
MIRT877839	hsa-miR-148b	CLIP-seq
MIRT877840	hsa-miR-152	CLIP-seq
MIRT1960144	hsa-miR-1909	CLIP-seq
MIRT877844	hsa-miR-1912	CLIP-seq
MIRT877848	hsa-miR-19a	CLIP-seq
MIRT877849	hsa-miR-19b	CLIP-seq
MIRT877850	hsa-miR-200a	CLIP-seq
MIRT1960150	hsa-miR-2355-3p	CLIP-seq
MIRT877857	hsa-miR-298	CLIP-seq
MIRT877858	hsa-miR-3117-5p	CLIP-seq
MIRT877860	hsa-miR-3135b	CLIP-seq
MIRT1960155	hsa-miR-3138	CLIP-seq
MIRT1960157	hsa-miR-3158-5p	CLIP-seq
MIRT1960158	hsa-miR-3166	CLIP-seq
MIRT877864	hsa-miR-3169	CLIP-seq
MIRT1546315	hsa-miR-3180	CLIP-seq
MIRT1546316	hsa-miR-3180-3p	CLIP-seq
MIRT877866	hsa-miR-3189-3p	CLIP-seq
MIRT1546317	hsa-miR-3196	CLIP-seq
MIRT877869	hsa-miR-323b-5p	CLIP-seq
MIRT877871	hsa-miR-342-5p	CLIP-seq
MIRT1960161	hsa-miR-346	CLIP-seq
MIRT877872	hsa-miR-34a	CLIP-seq
MIRT877874	hsa-miR-34c-5p	CLIP-seq
MIRT877876	hsa-miR-3609	CLIP-seq
MIRT877877	hsa-miR-3612	CLIP-seq
MIRT877879	hsa-miR-3616-3p	CLIP-seq
MIRT877880	hsa-miR-3646	CLIP-seq
MIRT877885	hsa-miR-369-3p	CLIP-seq
MIRT877886	hsa-miR-371-3p	CLIP-seq
MIRT877887	hsa-miR-374a	CLIP-seq
MIRT877888	hsa-miR-374b	CLIP-seq
MIRT1960166	hsa-miR-3939	CLIP-seq
MIRT877892	hsa-miR-3944-5p	CLIP-seq
MIRT1960167	hsa-miR-3974	CLIP-seq
MIRT877895	hsa-miR-4264	CLIP-seq
MIRT1960169	hsa-miR-4288	CLIP-seq
MIRT877898	hsa-miR-4436b-3p	CLIP-seq
MIRT1960176	hsa-miR-4443	CLIP-seq
MIRT1546318	hsa-miR-4447	CLIP-seq
MIRT1546319	hsa-miR-4456	CLIP-seq
MIRT2197049	hsa-miR-4457	CLIP-seq
MIRT877899	hsa-miR-4459	CLIP-seq
MIRT1546320	hsa-miR-4472	CLIP-seq
MIRT1960179	hsa-miR-4487	CLIP-seq
MIRT1546321	hsa-miR-4488	CLIP-seq
MIRT1960180	hsa-miR-4496	CLIP-seq
MIRT877903	hsa-miR-449a	CLIP-seq
MIRT877904	hsa-miR-449b	CLIP-seq
MIRT877905	hsa-miR-4515	CLIP-seq
MIRT877906	hsa-miR-4520a-3p	CLIP-seq
MIRT877907	hsa-miR-4520b-3p	CLIP-seq
MIRT1960182	hsa-miR-4529-5p	CLIP-seq
MIRT1960183	hsa-miR-4632	CLIP-seq
MIRT877909	hsa-miR-4640-5p	CLIP-seq
MIRT1960184	hsa-miR-4646-3p	CLIP-seq
MIRT877911	hsa-miR-4646-5p	CLIP-seq
MIRT877913	hsa-miR-4651	CLIP-seq
MIRT1960185	hsa-miR-4660	CLIP-seq
MIRT877915	hsa-miR-4664-5p	CLIP-seq
MIRT1546322	hsa-miR-4697-5p	CLIP-seq
MIRT2197050	hsa-miR-4710	CLIP-seq
MIRT1960190	hsa-miR-4711-3p	CLIP-seq
MIRT877921	hsa-miR-4722-5p	CLIP-seq
MIRT877924	hsa-miR-4726-5p	CLIP-seq
MIRT877925	hsa-miR-4731-5p	CLIP-seq
MIRT877926	hsa-miR-4736	CLIP-seq
MIRT877927	hsa-miR-4746-3p	CLIP-seq
MIRT877929	hsa-miR-4763-3p	CLIP-seq
MIRT1960194	hsa-miR-4771	CLIP-seq
MIRT877930	hsa-miR-4778-3p	CLIP-seq
MIRT1960195	hsa-miR-4800-5p	CLIP-seq
MIRT877936	hsa-miR-502-5p	CLIP-seq
MIRT1960196	hsa-miR-5047	CLIP-seq
MIRT877937	hsa-miR-511	CLIP-seq
MIRT2197051	hsa-miR-513b	CLIP-seq
MIRT877942	hsa-miR-520d-5p	CLIP-seq
MIRT877943	hsa-miR-520g	CLIP-seq
MIRT877944	hsa-miR-520h	CLIP-seq
MIRT877945	hsa-miR-524-5p	CLIP-seq
MIRT1546323	hsa-miR-541	CLIP-seq
MIRT877946	hsa-miR-544	CLIP-seq
MIRT1960198	hsa-miR-548a-3p	CLIP-seq
MIRT877952	hsa-miR-548ah	CLIP-seq
MIRT1960199	hsa-miR-548e	CLIP-seq
MIRT1960200	hsa-miR-548f	CLIP-seq
MIRT877969	hsa-miR-551a	CLIP-seq
MIRT877970	hsa-miR-551b	CLIP-seq
MIRT1960201	hsa-miR-561	CLIP-seq
MIRT877972	hsa-miR-570	CLIP-seq
MIRT877974	hsa-miR-608	CLIP-seq
MIRT877976	hsa-miR-617	CLIP-seq
MIRT877977	hsa-miR-622	CLIP-seq
MIRT1960206	hsa-miR-632	CLIP-seq
MIRT877979	hsa-miR-650	CLIP-seq
MIRT1546324	hsa-miR-654-5p	CLIP-seq
MIRT877980	hsa-miR-656	CLIP-seq
MIRT1960210	hsa-miR-668	CLIP-seq
MIRT877982	hsa-miR-671-5p	CLIP-seq
MIRT877985	hsa-miR-873	CLIP-seq
MIRT877986	hsa-miR-922	CLIP-seq
MIRT1960216	hsa-miR-943	CLIP-seq
MIRT877987	hsa-miR-96	CLIP-seq
MIRT877835	hsa-miR-1286	CLIP-seq
MIRT877858	hsa-miR-3117-5p	CLIP-seq
MIRT1546315	hsa-miR-3180	CLIP-seq
MIRT1546316	hsa-miR-3180-3p	CLIP-seq
MIRT1546317	hsa-miR-3196	CLIP-seq
MIRT877892	hsa-miR-3944-5p	CLIP-seq
MIRT1546318	hsa-miR-4447	CLIP-seq
MIRT1546319	hsa-miR-4456	CLIP-seq
MIRT1546320	hsa-miR-4472	CLIP-seq
MIRT1546321	hsa-miR-4488	CLIP-seq
MIRT877911	hsa-miR-4646-5p	CLIP-seq
MIRT1546322	hsa-miR-4697-5p	CLIP-seq
MIRT1546323	hsa-miR-541	CLIP-seq
MIRT877946	hsa-miR-544	CLIP-seq
MIRT1546324	hsa-miR-654-5p	CLIP-seq
MIRT1960198	hsa-miR-548a-3p	CLIP-seq
MIRT1960199	hsa-miR-548e	CLIP-seq
MIRT1960200	hsa-miR-548f	CLIP-seq
MIRT877860	hsa-miR-3135b	CLIP-seq
MIRT877877	hsa-miR-3612	CLIP-seq
MIRT1960165	hsa-miR-3925-3p	CLIP-seq
MIRT1960168	hsa-miR-4267	CLIP-seq
MIRT2436209	hsa-miR-4292	CLIP-seq
MIRT2436210	hsa-miR-4308	CLIP-seq
MIRT1960176	hsa-miR-4443	CLIP-seq
MIRT1960182	hsa-miR-4529-5p	CLIP-seq
MIRT877979	hsa-miR-650	CLIP-seq
MIRT1960213	hsa-miR-766	CLIP-seq
MIRT877870	hsa-miR-338-3p	CLIP-seq
MIRT877878	hsa-miR-361-3p	CLIP-seq
MIRT877908	hsa-miR-4530	CLIP-seq
MIRT877910	hsa-miR-4641	CLIP-seq
MIRT877923	hsa-miR-4726-3p	CLIP-seq
MIRT877984	hsa-miR-764	CLIP-seq

Show/Hide all(44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0004672	Function	Protein kinase activity	IDA	21949762
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9418861
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	TAS	9418861
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	ISS
GO:0006468	Process	Protein phosphorylation	IDA	21949762
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007010	Process	Cytoskeleton organization	TAS	9418861
GO:0007163	Process	Establishment or maintenance of cell polarity	TAS	9418861
GO:0007165	Process	Signal transduction	TAS	9418861
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016477	Process	Cell migration	IEA
GO:0016477	Process	Cell migration	IMP	18854160
GO:0016740	Function	Transferase activity	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031032	Process	Actomyosin structure organization	IBA
GO:0031032	Process	Actomyosin structure organization	IEA
GO:0031032	Process	Actomyosin structure organization	IMP	18854160
GO:0031252	Component	Cell leading edge	ISS
GO:0042641	Component	Actomyosin	IBA
GO:0042641	Component	Actomyosin	IDA	18854160
GO:0042641	Component	Actomyosin	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044877	Function	Protein-containing complex binding	IPI	25743393
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070161	Component	Anchoring junction	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
614062	1738	ENSG00000198752

Protein

UniProt ID

Q9Y5S2

Protein name

Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)

Protein function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C

PDB

3QFV , 3TKU , 4UAK , 4UAL , 5OTE , 5OTF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	76 → 342	Protein kinase domain	Domain
PF15796	KELK	527 → 606	KELK-motif containing domain of MRCK Ser/Thr protein kinase	Coiled-coil
PF08826	DMPK_coil	878 → 939	DMPK coiled coil domain like	Coiled-coil
PF00130	C1_1	1026 → 1077	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00780	CNH	1245 → 1510	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.

Sequence

MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK
PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC
FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY
IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP
DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF
QFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPD
VSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQ
SNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSN
SNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ
EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRD
KEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESE
LEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH
DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN
EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALAS
KMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV
KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL
AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG
PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE
QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPG
VIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN
EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEE
GLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI
KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLA
VLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLC
FSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGL
RRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV
PEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERP
GPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPS
NSSNPSGPPSPNSPHRSQLPLEGLEQPACDT

Sequence length

1711

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Neurodevelopmental Disorders	Chilton-Okur-Chung neurodevelopmental syndrome	rs1595127294, rs1595472741, rs1595472764, rs1595476797, rs1016320330	N/A
autism spectrum disorder	Autism spectrum disorder	rs1595127294	N/A

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	22464443, 30667325
Cerebral Palsy	Associate	40243517
Gastrointestinal Stromal Tumors	Associate	35319816
Myocardial Infarction	Associate	33836805
Myotonic Dystrophy	Associate	30667325
Neoplasms	Associate	16319398, 21352556
Optic Atrophy Hereditary Leber	Associate	36233195
Urinary Bladder Neoplasms	Associate	28193625

CDC42BPB (CDC42 binding protein kinase beta)