Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9559
Gene name Gene Name - the full gene name approved by the HGNC.
VPS26 retromer complex component A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VPS26A
Synonyms (NCBI Gene) Gene synonyms aliases
HB58, Hbeta58, PEP8A, VPS26
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004448 hsa-miR-373-3p Microarray 15685193
MIRT004448 hsa-miR-373-3p Microarray 15685193
MIRT025885 hsa-miR-7-5p Microarray 17612493
MIRT025885 hsa-miR-7-5p Microarray 19073608
MIRT031005 hsa-miR-21-5p Microarray 18591254
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11102511, 15078903, 16732284, 17891154, 19619496, 21725319, 24747528, 26496610, 27385586, 28514442, 28892079, 32296183, 32814053
GO:0005764 Component Lysosome IDA
GO:0005768 Component Endosome IBA 21873635
GO:0005768 Component Endosome IDA 20682791
GO:0005769 Component Early endosome IDA 15078903
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605506 12711 ENSG00000122958
Protein
UniProt ID O75436
Protein name Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)
Protein function Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins
PDB 2FAU , 5F0J , 5F0L , 5F0M , 5F0P , 7BLO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03643 Vps26 8 283 Vacuolar protein sorting-associated protein 26 Family
Sequence
Sequence length 327
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis   WNT ligand biogenesis and trafficking
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23300278, 21874001
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 23595767
Carcinoma Hepatocellular Associate 36834898
Diabetes Gestational Associate 29352517
Diabetes Mellitus Associate 27281273
Diabetes Mellitus Type 2 Associate 21874001, 23372846, 26395551, 27281273
Diabetic Retinopathy Associate 28821857
Myocardial Infarction Associate 39770895
Neoplasms Associate 36834898
Obesity Associate 26395551, 29752338, 30021629
Obesity Stimulate 30021629