MRPL33 (mitochondrial ribosomal protein L33)

Gene

• Entrez ID: 9553
• Gene name: Mitochondrial ribosomal protein L33
• Gene symbol: MRPL33
• Synonyms (NCBI Gene): C2orf1, L33mt, MRP-L33, RPL33L, bL33m
• Chromosome: 2
• Chromosome location: 2p23.2
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2045635	hsa-miR-205	CLIP-seq
MIRT2045636	hsa-miR-217	CLIP-seq
MIRT2045637	hsa-miR-3185	CLIP-seq
MIRT2045638	hsa-miR-33a	CLIP-seq
MIRT2045639	hsa-miR-33b	CLIP-seq
MIRT2045640	hsa-miR-3671	CLIP-seq
MIRT2045641	hsa-miR-4420	CLIP-seq
MIRT2045642	hsa-miR-4459	CLIP-seq
MIRT2045643	hsa-miR-4511	CLIP-seq
MIRT2045644	hsa-miR-4695-5p	CLIP-seq
MIRT2045645	hsa-miR-4762-5p	CLIP-seq
MIRT2045646	hsa-miR-513a-5p	CLIP-seq
MIRT2045647	hsa-miR-513b	CLIP-seq
MIRT2045648	hsa-miR-607	CLIP-seq
MIRT2391060	hsa-miR-1238	CLIP-seq
MIRT2391061	hsa-miR-1827	CLIP-seq
MIRT2391062	hsa-miR-2682	CLIP-seq
MIRT2391063	hsa-miR-34a	CLIP-seq
MIRT2391064	hsa-miR-34c-5p	CLIP-seq
MIRT2391065	hsa-miR-3612	CLIP-seq
MIRT2045642	hsa-miR-4459	CLIP-seq
MIRT2391066	hsa-miR-449a	CLIP-seq
MIRT2391067	hsa-miR-449b	CLIP-seq
MIRT2391068	hsa-miR-449c	CLIP-seq
MIRT2045644	hsa-miR-4695-5p	CLIP-seq
MIRT2391069	hsa-miR-4778-3p	CLIP-seq
MIRT2045646	hsa-miR-513a-5p	CLIP-seq
MIRT2391070	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 610059
• HGNC: 14487
• e!Ensembl: ENSG00000243147

Protein

• UniProt ID: O75394
• Protein name: Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)
• PDB: 3IY9, 3J7Y, 3J9M, 5OOL, 5OOM, 6I9R, 6NU2, 6NU3, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5H, 7A5I, 7A5J, 7A5K, 7L08, 7L20, 7O9K, 7O9M, 7ODR, 7ODS, 7ODT, 7OF0, 7OF2, 7OF3, 7OF4, 7OF5, 7OF6, 7OF7, 7OG4, 7OI7, 7OI8, 7OI9, 7OIA, 7OIB, 7OIC, 7OID, 7OIE, 7PD3, 7PO4, 7QH6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00471	Ribosomal_L33	11 → 60	Ribosomal protein L33	Family

• Sequence:

  MFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVVKQRVLFVEKK
  KIRSL

• Sequence length: 65

Pathways

KEGG:

Ribosome

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination