MRPL33 (mitochondrial ribosomal protein L33)

Gene

• Entrez ID: 9553
• Gene name: Mitochondrial ribosomal protein L33
• Gene symbol: MRPL33
• Synonyms (NCBI Gene): C2orf1, L33mt, MRP-L33, RPL33L, bL33m
• Chromosome: 2
• Chromosome location: 2p23.2
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2045635	hsa-miR-205	CLIP-seq
MIRT2045636	hsa-miR-217	CLIP-seq
MIRT2045637	hsa-miR-3185	CLIP-seq
MIRT2045638	hsa-miR-33a	CLIP-seq
MIRT2045639	hsa-miR-33b	CLIP-seq
MIRT2045640	hsa-miR-3671	CLIP-seq
MIRT2045641	hsa-miR-4420	CLIP-seq
MIRT2045642	hsa-miR-4459	CLIP-seq
MIRT2045643	hsa-miR-4511	CLIP-seq
MIRT2045644	hsa-miR-4695-5p	CLIP-seq
MIRT2045645	hsa-miR-4762-5p	CLIP-seq
MIRT2045646	hsa-miR-513a-5p	CLIP-seq
MIRT2045647	hsa-miR-513b	CLIP-seq
MIRT2045648	hsa-miR-607	CLIP-seq
MIRT2391060	hsa-miR-1238	CLIP-seq
MIRT2391061	hsa-miR-1827	CLIP-seq
MIRT2391062	hsa-miR-2682	CLIP-seq
MIRT2391063	hsa-miR-34a	CLIP-seq
MIRT2391064	hsa-miR-34c-5p	CLIP-seq
MIRT2391065	hsa-miR-3612	CLIP-seq
MIRT2045642	hsa-miR-4459	CLIP-seq
MIRT2391066	hsa-miR-449a	CLIP-seq
MIRT2391067	hsa-miR-449b	CLIP-seq
MIRT2391068	hsa-miR-449c	CLIP-seq
MIRT2045644	hsa-miR-4695-5p	CLIP-seq
MIRT2391069	hsa-miR-4778-3p	CLIP-seq
MIRT2045646	hsa-miR-513a-5p	CLIP-seq
MIRT2391070	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 610059
• HGNC: 14487
• e!Ensembl: ENSG00000243147

Protein

• UniProt ID: O75394
• Protein name: Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)
• PDB: 3IY9, 3J7Y, 3J9M, 5OOL, 5OOM, 6I9R, 6NU2, 6NU3, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5H, 7A5I, 7A5J, 7A5K, 7L08, 7L20, 7O9K, 7O9M, 7ODR, 7ODS, 7ODT, 7OF0, 7OF2, 7OF3, 7OF4, 7OF5, 7OF6, 7OF7, 7OG4, 7OI7, 7OI8, 7OI9, 7OIA, 7OIB, 7OIC, 7OID, 7OIE, 7PD3, 7PO4, 7QH6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00471	Ribosomal_L33	11 → 60	Ribosomal protein L33	Family

• Sequence:

  MFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVVKQRVLFVEKK
  KIRSL

• Sequence length: 65

Pathways

KEGG:

Ribosome

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Bipolar Disorder	Bipolar disorder, Bipolar I disorder	N/A	N/A	GWAS
Hypogonadism	Hypogonadism	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Urolithiasis	Urolithiasis	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Autism Spectrum Disorder	Associate	35306338
Diabetes Mellitus	Associate	28744461
Neoplasms	Associate	30816492
Neuroendocrine Tumors	Associate	37534217
Papillomavirus Infections	Associate	32164487
Stomach Neoplasms	Associate	30816492