Gene Gene information from NCBI Gene database.
Entrez ID 9538
Gene name EI24 autophagy associated transmembrane protein
Gene symbol EI24
Synonyms (NCBI Gene)
EPG4PIG8TP53I8
Chromosome 11
Chromosome location 11q24.2
Summary This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic
miRNA miRNA information provided by mirtarbase database.
431
miRTarBase ID miRNA Experiments Reference
MIRT029332 hsa-miR-26b-5p Microarray 19088304
MIRT638786 hsa-miR-129-5p HITS-CLIP 23824327
MIRT638785 hsa-miR-6499-3p HITS-CLIP 23824327
MIRT638784 hsa-miR-6081 HITS-CLIP 23824327
MIRT638783 hsa-miR-455-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605170 13276 ENSG00000149547
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14681
Protein name Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein)
Protein function Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07264 EI24 59 271 Family
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  p53 signaling pathway  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Intellectual disability Likely pathogenic rs1938981293 RCV001291079
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24921089
Adenocarcinoma of Lung Stimulate 30784913
Breast Neoplasms Associate 21803008
Carcinoma Non Small Cell Lung Associate 30784913
Liposarcoma Associate 22241790
Lymphatic Metastasis Associate 21803008
Neoplasm Metastasis Associate 30784913
Neoplasms Inhibit 22241790, 25496518, 28038450
Neoplasms Associate 30784913
Triple Negative Breast Neoplasms Associate 28038450