PTGES (prostaglandin E synthase)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9536 |
| Gene name | Prostaglandin E synthase |
| Gene symbol | PTGES |
| Synonyms (NCBI Gene) |
MGST-IVMGST1-L1MGST1L1MPGESPGESPIG12PP102PP1294TP53I12mPGES-1
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| Chromosome | 9 |
| Chromosome location | 9q34.11 |
| Summary | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr |
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miRNA
miRNA information provided by mirtarbase database.
658
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
7
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O14684 | ||||||||||
| Protein name | Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gen | ||||||||||
| Protein function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammator | ||||||||||
| PDB | 3DWW , 4AL0 , 4AL1 , 4BPM , 4WAB , 4YK5 , 4YL0 , 4YL1 , 4YL3 , 5BQG , 5BQH , 5BQI , 5K0I , 5T36 , 5T37 , 5TL9 , 6VL4 , 8PYV | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 152 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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