Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9536
Gene name Gene Name - the full gene name approved by the HGNC.
Prostaglandin E synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTGES
Synonyms (NCBI Gene) Gene synonyms aliases
MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017384 hsa-miR-335-5p Microarray 18185580
MIRT022404 hsa-miR-124-3p Microarray 18668037
MIRT046064 hsa-miR-125b-5p CLASH 23622248
MIRT608918 hsa-miR-8485 HITS-CLIP 23824327
MIRT611037 hsa-miR-2355-5p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 20688046
EGR1 Activation 21983014
HDAC4 Unknown 19115247
HIF1A Activation 18050215
NFKB1 Activation 17928629
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IBA 21873635
GO:0001516 Process Prostaglandin biosynthetic process IDA 18682561
GO:0002526 Process Acute inflammatory response IEA
GO:0002544 Process Chronic inflammatory response IEA
GO:0004364 Function Glutathione transferase activity IDA 12672824
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605172 9599 ENSG00000148344
Protein
UniProt ID O14684
Protein name Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gen
Protein function Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammator
PDB 3DWW , 4AL0 , 4AL1 , 4BPM , 4WAB , 4YK5 , 4YL0 , 4YL1 , 4YL3 , 5BQG , 5BQH , 5BQI , 5K0I , 5T36 , 5T37 , 5TL9 , 6VL4 , 8PYV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01124 MAPEG 16 146 MAPEG family Family
Sequence
Sequence length 152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Arachidonic acid metabolism
Metabolic pathways
  Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 27611488 ClinVar, GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Stimulate 18631945
Alzheimer Disease Inhibit 19001348
Alzheimer Disease Associate 19664621
Aneurysm Associate 22588264
Aneurysm Ruptured Associate 22588264
Aortic Aneurysm Associate 22588264
Aortic Aneurysm Abdominal Associate 24133193, 24876670
Arthritis Associate 15457451, 26225917, 32449517
Arthritis Stimulate 16255020
Arthritis Rheumatoid Associate 15188353, 16255020, 21298002, 21448233, 23488692, 33273889