Gene Gene information from NCBI Gene database.
Entrez ID 9536
Gene name Prostaglandin E synthase
Gene symbol PTGES
Synonyms (NCBI Gene)
MGST-IVMGST1-L1MGST1L1MPGESPGESPIG12PP102PP1294TP53I12mPGES-1
Chromosome 9
Chromosome location 9q34.11
Summary The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr
miRNA miRNA information provided by mirtarbase database.
658
miRTarBase ID miRNA Experiments Reference
MIRT017384 hsa-miR-335-5p Microarray 18185580
MIRT022404 hsa-miR-124-3p Microarray 18668037
MIRT046064 hsa-miR-125b-5p CLASH 23622248
MIRT608918 hsa-miR-8485 HITS-CLIP 23824327
MIRT611037 hsa-miR-2355-5p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
CREB1 Unknown 20688046
EGR1 Activation 21983014
HDAC4 Unknown 19115247
HIF1A Activation 18050215
NFKB1 Activation 17928629
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IBA
GO:0001516 Process Prostaglandin biosynthetic process IDA 18682561
GO:0001516 Process Prostaglandin biosynthetic process IEA
GO:0004364 Function Glutathione transferase activity IDA 12672824
GO:0004364 Function Glutathione transferase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605172 9599 ENSG00000148344
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14684
Protein name Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gen
Protein function Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammator
PDB 3DWW , 4AL0 , 4AL1 , 4BPM , 4WAB , 4YK5 , 4YL0 , 4YL1 , 4YL3 , 5BQG , 5BQH , 5BQI , 5K0I , 5T36 , 5T37 , 5TL9 , 6VL4 , 8PYV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01124 MAPEG 16 146 MAPEG family Family
Sequence
Sequence length 152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Arachidonic acid metabolism
Metabolic pathways
  Synthesis of Prostaglandins (PG) and Thromboxanes (TX)