Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9529
Gene name Gene Name - the full gene name approved by the HGNC.
BAG cochaperone 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BAG5
Synonyms (NCBI Gene) Gene synonyms aliases
BAG-5, CMD2F
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CMD2F
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020553 hsa-miR-155-5p Proteomics 18668040
MIRT022122 hsa-miR-124-3p Microarray 18668037
MIRT023533 hsa-miR-1-3p Proteomics 18668040
MIRT032220 hsa-let-7b-5p Proteomics 18668040
MIRT041624 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000774 Function Adenyl-nucleotide exchange factor activity IBA 21873635
GO:0005515 Function Protein binding IPI 24510904, 24947832, 25036637, 25416956, 31515488, 32296183
GO:0005634 Component Nucleus HDA 21630459
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 24510904
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603885 941 ENSG00000166170
Protein
UniProt ID Q9UL15
Protein name BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
Protein function Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis a
PDB 2D9D , 3A8Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02179 BAG 13 85 BAG domain Family
PF02179 BAG 185 258 BAG domain Family
PF02179 BAG 279 349 BAG domain Family
PF02179 BAG 369 441 BAG domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the heart. {ECO:0000269|PubMed:35044787}.
Sequence
Sequence length 447
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of HSF1-mediated heat shock response
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Parkinson disease Parkinson Disease rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432
View all (84 more)
28348719
Unknown
Disease term Disease name Evidence References Source
Cardiomyopathy cardiomyopathy, dilated, 2F GenCC
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 40033250
Huntington Disease Associate 33049985
Lymphoma Non Hodgkin Associate 20855536
Ovarian Neoplasms Inhibit 34126157
Parkinson Disease Associate 24510904
Prostatic Neoplasms Associate 23448667
Thyroid Cancer Papillary Stimulate 32275930