Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9520
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Aminopeptidase puromycin sensitive |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NPEPPS |
Synonyms (NCBI Gene)
Gene synonyms aliases
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AAP-S, MP100, PSA |
Chromosome
Chromosome number
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17 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.32 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkap |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Amyotrophic lateral sclerosis |
Amyotrophic Lateral Sclerosis |
rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs371575563, rs1402429085, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087 View all (171 more) |
24234648 |
Multiple sclerosis |
Multiple Sclerosis |
rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544 View all (4 more) |
24234648 |
Psoriasis |
Psoriasis |
rs281875215, rs587777763, rs281875213, rs281875212 |
26974007 |
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Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Crohn disease |
Crohn Disease |
|
26974007 |
ClinVar |
Ankylosing Spondylitis |
Ankylosing Spondylitis |
|
|
GWAS |
Multiple Sclerosis |
Multiple Sclerosis |
|
|
GWAS |
Prostate cancer |
Prostate cancer |
Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. |
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GWAS, CBGDA |
Glaucoma |
Glaucoma |
|
|
GWAS |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Acrodysostosis |
Associate
|
32783359 |
Adenocarcinoma |
Associate
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30402808, 32512818 |
Adenocarcinoma |
Stimulate
|
34606082, 9712452 |
Adenoma |
Stimulate
|
26078706 |
Alzheimer Disease |
Associate
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32854315 |
Amyloidosis |
Associate
|
35418036 |
Bone Diseases |
Associate
|
10569618 |
Calcinosis Cutis |
Stimulate
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23826159 |
Cap Myopathy |
Associate
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20860009 |
Carcinoma Renal Cell |
Associate
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16985214, 18216146 |
Colorectal Neoplasms |
Associate
|
26078706 |
Death |
Associate
|
39300507 |
Diabetic Nephropathies |
Associate
|
36444934 |
Disease |
Associate
|
29339080 |
Hashimoto Disease |
Associate
|
25380293 |
Ichthyosis |
Associate
|
32783359 |
Leukemia |
Associate
|
23071732 |
Leukemia Myelogenous Chronic BCR ABL Positive |
Associate
|
35798533 |
Lung Neoplasms |
Associate
|
35650221 |
Mouth Neoplasms |
Associate
|
28534379 |
Neoplasm Metastasis |
Stimulate
|
23826159 |
Neoplasm Metastasis |
Associate
|
31296901, 35101049 |
Neoplasm Micrometastasis |
Associate
|
23766685 |
Neoplasms |
Associate
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16381942, 16985214, 24747912, 25797255, 26030748, 26862729, 26871947, 28259631, 31383039, 8461645 |
Neoplasms |
Stimulate
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23359198, 23690220 |
Neoplasms |
Inhibit
|
26078706 |
Oncocytoma renal |
Associate
|
18216146 |
Pancreatic Neoplasms |
Associate
|
23071732 |
Parkinson Disease |
Associate
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35101049 |
PICA syndrome |
Associate
|
28675346 |
Prostate cancer familial |
Inhibit
|
26989049 |
Prostate cancer familial |
Stimulate
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9712452 |
Prostate Cancer Hereditary 7 |
Stimulate
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33204318 |
Prostatic Diseases |
Inhibit
|
17980063 |
Prostatic Hyperplasia |
Associate
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19676094, 28327526 |
Prostatic Neoplasms |
Associate
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10569618, 11857020, 15655565, 16381942, 18646000, 18697814, 18846227, 18849534, 20180647, 21049281, 21129724, 21600800, 21647377, 22234006, 22302420, 22596233, 22642976, 22672250, 22729556, 22792137, 23826159, 23958433, 24391718, 24418088, 24418912, 25101567, 25352524, 25762627, 25969992, 26013479, 26458958, 26616116, 26754263, 26939004, 27058620, 27170485, 27741522, 27893706, 27903962, 28300564, 28460462, 28974201, 28993510, 29203798, 29248950, 29523813, 30073682, 30139231, 30396163, 30958616, 30989489, 31210308, 31449673, 33397422, 33541309, 33866309, 33903734, 34382671, 35058329, 36017197, 36553586, 36656332, 37092584, 37481706, 38017230, 39333312, 39337607, 40312902 View all (53 more) |
Prostatic Neoplasms |
Stimulate
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25245366, 31901908 |
Prostatic Neoplasms Castration Resistant |
Associate
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34538582, 35058329, 36519763 |
Prostatitis |
Associate
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15314219, 25904191, 31216740, 36081431, 39337607 |
Pyruvate Carboxylase Deficiency Disease |
Associate
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22815971 |
Recurrence |
Associate
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24714743 |
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