Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	952
Gene name	CD38 molecule
Gene symbol	CD38
Synonyms (NCBI Gene)	ADPRC 1ADPRC1cADPR1
Chromosome	4
Chromosome location	4p15.32
Summary	The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5`-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018938	hsa-miR-335-5p	Microarray	18185580
MIRT053006	hsa-miR-140-3p	Luciferase reporter assayqRT-PCR	22773691
MIRT504921	hsa-miR-5692a	PAR-CLIP	21572407
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	21572407
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT504909	hsa-miR-659-3p	PAR-CLIP	21572407
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT734721	hsa-miR-26a-5p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCRELISA	31907356
MIRT053006	hsa-miR-140-3p	Western blotting	33121100
MIRT736433	hsa-miR-26b-5p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCRELISA	31907356
MIRT504921	hsa-miR-5692a	PAR-CLIP	21572407
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	21572407
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT504909	hsa-miR-659-3p	PAR-CLIP	21572407
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT1959493	hsa-miR-1226	CLIP-seq
MIRT1959494	hsa-miR-214	CLIP-seq
MIRT1959495	hsa-miR-3130-3p	CLIP-seq
MIRT1959496	hsa-miR-3194-3p	CLIP-seq
MIRT1959497	hsa-miR-3619-5p	CLIP-seq
MIRT1959498	hsa-miR-4530	CLIP-seq
MIRT1959499	hsa-miR-4793-3p	CLIP-seq
MIRT1959500	hsa-miR-634	CLIP-seq
MIRT1959501	hsa-miR-761	CLIP-seq
MIRT1959502	hsa-miR-767-5p	CLIP-seq
MIRT2499500	hsa-miR-3137	CLIP-seq
MIRT2499501	hsa-miR-3202	CLIP-seq
MIRT2499502	hsa-miR-4476	CLIP-seq
MIRT2499503	hsa-miR-4670-3p	CLIP-seq
MIRT2499504	hsa-miR-584	CLIP-seq
MIRT2499505	hsa-miR-591	CLIP-seq

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Transcription factor	Regulation	Reference
MYC	Activation	11519042
NFKB1	Unknown	17322278;18341691;18441094
RELA	Unknown	17322278;18341691;18441094

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS	8253715
GO:0007165	Process	Signal transduction	NAS	8253715
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IMP	17875758
GO:0009725	Process	Response to hormone	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0014824	Process	Artery smooth muscle contraction	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8253715
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IBA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0019674	Process	NAD+ metabolic process	TAS
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	IBA
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	IMP	17875758
GO:0031965	Component	Nuclear membrane	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0033194	Process	Response to hydroperoxide	IEA
GO:0034097	Process	Response to cytokine	IEA
GO:0042100	Process	B cell proliferation	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	17875758
GO:0045779	Process	Negative regulation of bone resorption	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	17875758
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	17875758
GO:0045907	Process	Positive regulation of vasoconstriction	IEA
GO:0050853	Process	B cell receptor signaling pathway	IMP	17875758
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0061809	Function	NAD+ nucleosidase activity, cyclic ADP-ribose generating	IEA
GO:0061809	Function	NAD+ nucleosidase activity, cyclic ADP-ribose generating	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070555	Process	Response to interleukin-1	IEA
GO:0097190	Process	Apoptotic signaling pathway	TAS	10777496

MIM	HGNC	e!Ensembl
107270	1667	ENSG00000004468

P28907

Protein name

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl c

Protein function

Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nic

PDB

1YH3 , 1ZVM , 2EF1 , 2HCT , 2I65 , 2I66 , 2I67 , 2O3Q , 2O3R , 2O3S , 2O3T , 2O3U , 2PGJ , 2PGL , 3DZF , 3DZG , 3DZH , 3DZI , 3DZJ , 3DZK , 3F6Y , 3I9M , 3I9N , 3OFS , 3RAJ , 3ROK , 3ROM , 3ROP , 3ROQ , 3U4H , 3U4I , 4CMH , 4F45 , 4F46 , 4OGW , 4TMF , 4XJS , 4XJT , 5F1K , 5F1O , 5F21 , 6EDR , 6VUA , 7DHA , 7DUO , 7VKE , 8BYU , 8D0M , 8IL3 , 8P8C , 8VAU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02267	Rib_hydrolayse	56 → 296	ADP-ribosyl cyclase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:8253715, ECO:0000269|PubMed:9074508}.

Sequence

MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

Sequence length

300

Interactions

View interactions

	KEGG		Reactome
	Nicotinate and nicotinamide metabolism Metabolic pathways Calcium signaling pathway Hematopoietic cell lineage Oxytocin signaling pathway Salivary secretion Pancreatic secretion		Nicotinate metabolism

CD38 (CD38 molecule)