Gene Gene information from NCBI Gene database.
Entrez ID 9507
Gene name ADAM metallopeptidase with thrombospondin type 1 motif 4
Gene symbol ADAMTS4
Synonyms (NCBI Gene)
ADAMTS-2ADAMTS-4ADMP-1
Chromosome 1
Chromosome location 1q23.3
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegr
miRNA miRNA information provided by mirtarbase database.
859
miRTarBase ID miRNA Experiments Reference
MIRT019411 hsa-miR-148b-3p Microarray 17612493
MIRT022022 hsa-miR-128-3p Microarray 17612493
MIRT504253 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT504252 hsa-miR-190a-3p HITS-CLIP 21572407
MIRT504251 hsa-miR-3149 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development TAS 10356395
GO:0002020 Function Protease binding IPI 14744861
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IDA 14744861
GO:0004222 Function Metalloendopeptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603876 220 ENSG00000158859
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75173
Protein name A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)
Protein function Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in
PDB 2RJP , 3B2Z , 4WK7 , 4WKE , 4WKI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01562 Pep_M12B_propep 54 181 Reprolysin family propeptide Family
PF01421 Reprolysin 218 428 Reprolysin (M12B) family zinc metalloprotease Domain
PF17771 ADAM_CR_2 439 507 ADAM cysteine-rich domain Domain
PF00090 TSP_1 524 574 Thrombospondin type 1 domain Domain
PF05986 ADAM_spacer1 686 803 ADAM-TS Spacer 1 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278). {ECO:0000269|PubMe
Sequence
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
L
RRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKP
EAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCL
HMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC
PTGSALTFREEQCAAYNHRTDLFKSF
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
LTLQVLVAGNPQDTRLRYSFFVP
RPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
Sequence length 837
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Degradation of the extracellular matrix
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins