Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
950
Gene name Gene Name - the full gene name approved by the HGNC.
Scavenger receptor class B member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SCARB2
Synonyms (NCBI Gene) Gene synonyms aliases
AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
Disease Acronyms (UniProt) Disease acronyms from UniProt database
EPM4
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorgani
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs117157204 C>T Conflicting-interpretations-of-pathogenicity, benign Missense variant, coding sequence variant
rs117600063 T>A Conflicting-interpretations-of-pathogenicity, uncertain-significance Missense variant, coding sequence variant, intron variant
rs121909118 G>A Pathogenic Stop gained, coding sequence variant
rs121909119 C>T Pathogenic Stop gained, coding sequence variant, intron variant
rs143518519 G>A Benign, conflicting-interpretations-of-pathogenicity Synonymous variant, intron variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025719 hsa-miR-7-5p Microarray 17612493
MIRT025719 hsa-miR-7-5p Microarray 19073608
MIRT049516 hsa-miR-92a-3p CLASH 23622248
MIRT046711 hsa-miR-222-3p CLASH 23622248
MIRT044021 hsa-miR-365a-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
SPI1 Unknown 8007948
STAT2 Unknown 17998316
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS 25202012
GO:0001618 Function Virus receptor activity IEA
GO:0001786 Function Phosphatidylserine binding ISS 29199275
GO:0004888 Function Transmembrane signaling receptor activity TAS 25202012
GO:0005044 Function Scavenger receptor activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602257 1665 ENSG00000138760
Protein
UniProt ID Q14108
Protein name Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)
Protein function Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. ; (Microbial infection) Acts as a receptor for enterovirus 71.
PDB 4F7B , 4Q4B , 4Q4F , 4TVZ , 4TW0 , 4TW2 , 5UPH , 5XBM , 6I2K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01130 CD36 11 457 CD36 family Family
Sequence
Sequence length 478
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysosome   Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Action myoclonus-renal failure syndrome Action Myoclonus-Renal Failure Syndrome, Action myoclonus-renal failure syndrome rs727502772, rs727502773, rs121909118, rs121909119, rs727502781, rs727502782, rs200053119, rs886041078, rs886041077, rs886041076, rs886041075, rs995674389, rs1553948516, rs1578733075 19847901, 18424452, 22032306, 21670406, 19454373, 18308289, 22767442, 23225201, 21796727, 19597094, 23659519, 24485911, 23325613, 24620919, 24339182
View all (1 more)
Anemia Anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Epilepsy Epilepsy, Rolandic rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)
29358611
Unknown
Disease term Disease name Evidence References Source
Cirrhosis Cirrhosis ClinVar
Myoclonic Epilepsy Unverricht-Lundborg syndrome GenCC
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Ataxia Associate 22050460, 35346091
Carcinoma Hepatocellular Associate 20419844
Carcinoma Renal Cell Associate 35508649
Cardiomyopathy Dilated Associate 22032306
Cognition Disorders Associate 35346091
Congenital Hereditary and Neonatal Diseases and Abnormalities Associate 28222800
Deafness Associate 28222800
Demyelinating Diseases Associate 22032306
Disorders of Excessive Somnolence Associate 28198671
Dysarthria Associate 35346091