Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9493
Gene name Gene Name - the full gene name approved by the HGNC.
Kinesin family member 23
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KIF23
Synonyms (NCBI Gene) Gene synonyms aliases
CDA3, CDAIII, CDAN3, CDAN3A, CHO1, KNSL5, MKLP-1, MKLP1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CDAN3A
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q23
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs748016594 T>A,C Likely-pathogenic Non coding transcript variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000657 hsa-miR-424-5p Luciferase reporter assay 19956200
MIRT002495 hsa-miR-373-3p Microarray 15685193
MIRT002495 hsa-miR-373-3p Microarray;Other 15685193
MIRT020426 hsa-miR-106b-5p Microarray 17242205
MIRT024496 hsa-miR-215-5p Microarray 19074876
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000022 Process Mitotic spindle elongation TAS 1406973
GO:0000281 Process Mitotic cytokinesis IMP 15843429, 16236794
GO:0003777 Function Microtubule motor activity IBA 21873635
GO:0005515 Function Protein binding IPI 11782313, 14676191, 15161933, 15197175, 16236794, 16431929, 18201571, 18329369, 19468300, 20451386, 22522702, 22580824, 22750944, 26496610, 27528609, 28514442
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605064 6392 ENSG00000137807
Protein
UniProt ID Q02241
Protein name Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1)
Protein function Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling.
PDB 3VHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00225 Kinesin 31 436 Kinesin motor domain Domain
PF16540 MKLP1_Arf_bdg 803 906 Arf6-interacting domain of mitotic kinesin-like protein 1 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:23570799}.
Sequence
MKSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGY
RLNRNGDYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTH
TMTGSPGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMP
NPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFD
PIKPKPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSR
SHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREAGNI
NQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDY
EENLQVMRFAEVTQEV
EVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPL
PSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKENHM
QGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKL
QRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLKQLKAIVTE
PKTEKPERPSRERDREKVTQRSVSPSPVPLSSNYIAQISNGQQLMSQPQLHRRSNSCSSI
SVASCISEWEQKIPTYNTPLKVTSIARRRQQEPGQSKTCIVSDRRRGMYWTEGREVVPTF
RNEIEIEEDHCGRLLFQPDQNAPPIRLRHRRSRSAGDRWVDHKPASNMQTETVMQPHVPH
AITVSVANEKALAKCEKYMLTHQELASDGEIETKLIKGDIYKTRGGGQSVQFTDIETLKQ
ESPNGS
RKRRSSTVAPAQPDGAESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP
Sequence length 960
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Motor proteins
MicroRNAs in cancer
  MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Telophase/Cytokinesis
Kinesins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia, Congenital dyserythropoietic anemia, type III rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
23570799, 7323912
Congenital dyserythropoietic anemia Congenital dyserythropoietic anemia type III rs121918221, rs121918222, rs121918224, rs121918225, rs121918226, rs80338697, rs80338699, rs120074166, rs120074167, rs120074168, rs120074169, rs80338694, rs80338696, rs398124225, rs398124226
View all (8 more)
Hyperbilirubinemia Hyperbilirubinemia rs34993780, rs587784535, rs797046090, rs797046091
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33148251
Anemia Dyserythropoietic Congenital Associate 23570799
Breast Neoplasms Associate 24391143, 30593585, 31758680, 34675265
Carcinogenesis Associate 35524313
Carcinoma Hepatocellular Stimulate 26674738
Carcinoma Hepatocellular Associate 34324544, 34983303, 40255404
Carcinoma Non Small Cell Lung Associate 21412013
Carcinoma Ovarian Epithelial Associate 33726773
Carcinoma Pancreatic Ductal Associate 29483831
Carcinoma Renal Cell Associate 28260099, 32481352