Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9489
Gene name	Phosphatidylglycerophosphate synthase 1
Gene symbol	PGS1
Synonyms (NCBI Gene)	-
Chromosome	17
Chromosome location	17q25.3

125

Show/Hide all (125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016033	hsa-miR-374b-5p	Sequencing	20371350
MIRT1228715	hsa-miR-1184	CLIP-seq
MIRT1228716	hsa-miR-1205	CLIP-seq
MIRT1228717	hsa-miR-122	CLIP-seq
MIRT1228718	hsa-miR-1224-5p	CLIP-seq
MIRT1228719	hsa-miR-1294	CLIP-seq
MIRT1228720	hsa-miR-1908	CLIP-seq
MIRT1228721	hsa-miR-2467-3p	CLIP-seq
MIRT1228722	hsa-miR-3074-5p	CLIP-seq
MIRT1228723	hsa-miR-3132	CLIP-seq
MIRT1228724	hsa-miR-3135b	CLIP-seq
MIRT1228725	hsa-miR-3141	CLIP-seq
MIRT1228726	hsa-miR-3158-5p	CLIP-seq
MIRT1228727	hsa-miR-3166	CLIP-seq
MIRT1228728	hsa-miR-3170	CLIP-seq
MIRT1228729	hsa-miR-3194-3p	CLIP-seq
MIRT1228730	hsa-miR-323-3p	CLIP-seq
MIRT1228731	hsa-miR-3607-3p	CLIP-seq
MIRT1228732	hsa-miR-3653	CLIP-seq
MIRT1228733	hsa-miR-3658	CLIP-seq
MIRT1228734	hsa-miR-3664-5p	CLIP-seq
MIRT1228735	hsa-miR-3667-3p	CLIP-seq
MIRT1228736	hsa-miR-3678-3p	CLIP-seq
MIRT1228737	hsa-miR-3686	CLIP-seq
MIRT1228738	hsa-miR-3941	CLIP-seq
MIRT1228739	hsa-miR-4260	CLIP-seq
MIRT1228740	hsa-miR-4267	CLIP-seq
MIRT1228741	hsa-miR-4270	CLIP-seq
MIRT1228742	hsa-miR-4316	CLIP-seq
MIRT1228743	hsa-miR-4436b-3p	CLIP-seq
MIRT1228744	hsa-miR-4441	CLIP-seq
MIRT1228745	hsa-miR-4451	CLIP-seq
MIRT1228746	hsa-miR-4471	CLIP-seq
MIRT1228747	hsa-miR-4643	CLIP-seq
MIRT1228748	hsa-miR-4653-3p	CLIP-seq
MIRT1228749	hsa-miR-466	CLIP-seq
MIRT1228750	hsa-miR-4672	CLIP-seq
MIRT1228751	hsa-miR-4706	CLIP-seq
MIRT1228752	hsa-miR-4714-5p	CLIP-seq
MIRT1228753	hsa-miR-4722-3p	CLIP-seq
MIRT1228754	hsa-miR-4732-5p	CLIP-seq
MIRT1228755	hsa-miR-4749-5p	CLIP-seq
MIRT1228756	hsa-miR-4751	CLIP-seq
MIRT1228757	hsa-miR-4761-3p	CLIP-seq
MIRT1228758	hsa-miR-4775	CLIP-seq
MIRT1228759	hsa-miR-4789-3p	CLIP-seq
MIRT1228760	hsa-miR-574-5p	CLIP-seq
MIRT1228761	hsa-miR-590-3p	CLIP-seq
MIRT1228762	hsa-miR-663	CLIP-seq
MIRT2067000	hsa-miR-1207-3p	CLIP-seq
MIRT2067001	hsa-miR-1228	CLIP-seq
MIRT2067002	hsa-miR-1245b-3p	CLIP-seq
MIRT2067003	hsa-miR-193a-3p	CLIP-seq
MIRT2067004	hsa-miR-193b	CLIP-seq
MIRT2067005	hsa-miR-2467-5p	CLIP-seq
MIRT2067006	hsa-miR-3064-3p	CLIP-seq
MIRT2067007	hsa-miR-3176	CLIP-seq
MIRT2067008	hsa-miR-3188	CLIP-seq
MIRT2067009	hsa-miR-3647-3p	CLIP-seq
MIRT2067010	hsa-miR-3922-3p	CLIP-seq
MIRT2067011	hsa-miR-3975	CLIP-seq
MIRT1228739	hsa-miR-4260	CLIP-seq
MIRT2067012	hsa-miR-4469	CLIP-seq
MIRT2067013	hsa-miR-4766-5p	CLIP-seq
MIRT2067014	hsa-miR-4786-3p	CLIP-seq
MIRT2067015	hsa-miR-485-5p	CLIP-seq
MIRT2067016	hsa-miR-553	CLIP-seq
MIRT2067017	hsa-miR-760	CLIP-seq
MIRT2067018	hsa-miR-885-3p	CLIP-seq
MIRT2067019	hsa-miR-892b	CLIP-seq
MIRT2067000	hsa-miR-1207-3p	CLIP-seq
MIRT2592418	hsa-miR-1225-3p	CLIP-seq
MIRT2592419	hsa-miR-1233	CLIP-seq
MIRT2592420	hsa-miR-1972	CLIP-seq
MIRT2592421	hsa-miR-2115	CLIP-seq
MIRT2067005	hsa-miR-2467-5p	CLIP-seq
MIRT2067006	hsa-miR-3064-3p	CLIP-seq
MIRT2592422	hsa-miR-3158-3p	CLIP-seq
MIRT2592423	hsa-miR-3160-3p	CLIP-seq
MIRT2067007	hsa-miR-3176	CLIP-seq
MIRT2067008	hsa-miR-3188	CLIP-seq
MIRT2067009	hsa-miR-3647-3p	CLIP-seq
MIRT2067010	hsa-miR-3922-3p	CLIP-seq
MIRT2067011	hsa-miR-3975	CLIP-seq
MIRT2592424	hsa-miR-4326	CLIP-seq
MIRT2592425	hsa-miR-4487	CLIP-seq
MIRT2592426	hsa-miR-4493	CLIP-seq
MIRT2592427	hsa-miR-4529-5p	CLIP-seq
MIRT2592428	hsa-miR-4663	CLIP-seq
MIRT2592429	hsa-miR-4721	CLIP-seq
MIRT2592430	hsa-miR-4757-5p	CLIP-seq
MIRT2067013	hsa-miR-4766-5p	CLIP-seq
MIRT2067015	hsa-miR-485-5p	CLIP-seq
MIRT2592431	hsa-miR-502-5p	CLIP-seq
MIRT2592432	hsa-miR-516a-3p	CLIP-seq
MIRT2067016	hsa-miR-553	CLIP-seq
MIRT2592433	hsa-miR-558	CLIP-seq
MIRT2067017	hsa-miR-760	CLIP-seq
MIRT2067018	hsa-miR-885-3p	CLIP-seq
MIRT2592418	hsa-miR-1225-3p	CLIP-seq
MIRT2592419	hsa-miR-1233	CLIP-seq
MIRT2592420	hsa-miR-1972	CLIP-seq
MIRT2592421	hsa-miR-2115	CLIP-seq
MIRT2067005	hsa-miR-2467-5p	CLIP-seq
MIRT2067006	hsa-miR-3064-3p	CLIP-seq
MIRT2592422	hsa-miR-3158-3p	CLIP-seq
MIRT2592423	hsa-miR-3160-3p	CLIP-seq
MIRT2067008	hsa-miR-3188	CLIP-seq
MIRT2067009	hsa-miR-3647-3p	CLIP-seq
MIRT2067011	hsa-miR-3975	CLIP-seq
MIRT2592424	hsa-miR-4326	CLIP-seq
MIRT2592425	hsa-miR-4487	CLIP-seq
MIRT2592426	hsa-miR-4493	CLIP-seq
MIRT2592427	hsa-miR-4529-5p	CLIP-seq
MIRT2592428	hsa-miR-4663	CLIP-seq
MIRT2592429	hsa-miR-4721	CLIP-seq
MIRT2592430	hsa-miR-4757-5p	CLIP-seq
MIRT2067013	hsa-miR-4766-5p	CLIP-seq
MIRT2067015	hsa-miR-485-5p	CLIP-seq
MIRT2592431	hsa-miR-502-5p	CLIP-seq
MIRT2592432	hsa-miR-516a-3p	CLIP-seq
MIRT2067016	hsa-miR-553	CLIP-seq
MIRT2592433	hsa-miR-558	CLIP-seq
MIRT2067017	hsa-miR-760	CLIP-seq
MIRT2067018	hsa-miR-885-3p	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	38322995
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS	11171073
GO:0005759	Component	Mitochondrial matrix	TAS	11171073
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006655	Process	Phosphatidylglycerol biosynthetic process	IEA
GO:0006655	Process	Phosphatidylglycerol biosynthetic process	ISS
GO:0008444	Function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA
GO:0008444	Function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IEA
GO:0008444	Function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	ISS
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032049	Process	Cardiolipin biosynthetic process	IBA
GO:0032049	Process	Cardiolipin biosynthetic process	IEA
GO:0032049	Process	Cardiolipin biosynthetic process	ISS
GO:0032049	Process	Cardiolipin biosynthetic process	TAS	38322995
GO:0046339	Process	Diacylglycerol metabolic process	ISS

MIM	HGNC	e!Ensembl
614942	30029	ENSG00000087157

Q32NB8

Protein name

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)

Protein function

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.

Family and domains

Sequence

MAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRSPWLLLAPLLSP
AVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIRVAKRR
VVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLL
PLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDS
YFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYC
KAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPF
EIQIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFG
AKGVAGAIPAAYVHIERQFFSEVCSLGQQERVQLQEYWRRGWTFHAKGLWLYLAGSSLPC
LTLIGSPNFGYRSVHRDLEAQIAIVTENQALQQQLHQEQEQLYLRSGVVSSATFEQPSRQ
VKLWVKMVTPLIKNFF

Sequence length

556

Interactions

View interactions

	KEGG
	Glycerophospholipid metabolism Metabolic pathways

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
High myopia	Uncertain significance	rs372229822	RCV000785710
Lung cancer	Likely benign	rs201673197	RCV005939389
Malignant tumor of esophagus	Likely benign	rs201673197	RCV005939388
PGS1-related disorder	Likely benign	rs72914863	RCV003903842

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Cardiomyopathies	Associate	38291374
Mucocutaneous Lymph Node Syndrome	Associate	36042431
Myopathy with Giant Abnormal Mitochondria	Associate	38291374
Optic Atrophy Autosomal Dominant	Associate	34014035
Papillary Thyroid Microcarcinoma	Associate	34731936
Shock Septic	Associate	39609718
Sleep Deprivation	Associate	34014035

PGS1 (phosphatidylglycerophosphate synthase 1)