Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9481
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 25 member 27
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC25A27
Synonyms (NCBI Gene) Gene synonyms aliases	UCP4
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p12.3
Summary Summary of gene provided in NCBI Entrez Gene.	Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proto

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miRTarBase ID	miRNA	Experiments	Reference
MIRT509160	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT509159	hsa-miR-5692b	HITS-CLIP	21572407
MIRT509158	hsa-miR-5692c	HITS-CLIP	21572407
MIRT509157	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707273	hsa-miR-6792-5p	HITS-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707272	hsa-miR-4503	HITS-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509160	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT509159	hsa-miR-5692b	HITS-CLIP	21572407
MIRT509158	hsa-miR-5692c	HITS-CLIP	21572407
MIRT509157	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509160	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT509159	hsa-miR-5692b	HITS-CLIP	23313552
MIRT509158	hsa-miR-5692c	HITS-CLIP	23313552
MIRT509157	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT509160	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT509159	hsa-miR-5692b	HITS-CLIP	23824327
MIRT509158	hsa-miR-5692c	HITS-CLIP	23824327
MIRT509157	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	23824327
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	23824327
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT509159	hsa-miR-5692b	PAR-CLIP	21572407
MIRT509158	hsa-miR-5692c	PAR-CLIP	21572407
MIRT509157	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT509159	hsa-miR-5692b	PAR-CLIP	21572407
MIRT509158	hsa-miR-5692c	PAR-CLIP	21572407
MIRT509157	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT509159	hsa-miR-5692b	PAR-CLIP	23446348
MIRT509158	hsa-miR-5692c	PAR-CLIP	23446348
MIRT509157	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509160	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT509159	hsa-miR-5692b	PAR-CLIP	23446348
MIRT509158	hsa-miR-5692c	PAR-CLIP	23446348
MIRT509157	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509160	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT509159	hsa-miR-5692b	HITS-CLIP	21572407
MIRT509158	hsa-miR-5692c	HITS-CLIP	21572407
MIRT509157	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707273	hsa-miR-6792-5p	HITS-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707272	hsa-miR-4503	HITS-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509160	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT509159	hsa-miR-5692b	HITS-CLIP	21572407
MIRT509158	hsa-miR-5692c	HITS-CLIP	21572407
MIRT509157	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509160	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT509159	hsa-miR-5692b	HITS-CLIP	23313552
MIRT509158	hsa-miR-5692c	HITS-CLIP	23313552
MIRT509157	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT509160	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT509159	hsa-miR-5692b	HITS-CLIP	23824327
MIRT509158	hsa-miR-5692c	HITS-CLIP	23824327
MIRT509157	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT509156	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509155	hsa-miR-374a-5p	HITS-CLIP	23824327
MIRT509154	hsa-miR-374b-5p	HITS-CLIP	23824327
MIRT509153	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509152	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT509159	hsa-miR-5692b	PAR-CLIP	21572407
MIRT509158	hsa-miR-5692c	PAR-CLIP	21572407
MIRT509157	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT509159	hsa-miR-5692b	PAR-CLIP	21572407
MIRT509158	hsa-miR-5692c	PAR-CLIP	21572407
MIRT509157	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509160	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT509159	hsa-miR-5692b	PAR-CLIP	23446348
MIRT509158	hsa-miR-5692c	PAR-CLIP	23446348
MIRT509157	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509160	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT509159	hsa-miR-5692b	PAR-CLIP	23446348
MIRT509158	hsa-miR-5692c	PAR-CLIP	23446348
MIRT509157	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509156	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509155	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT509154	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509153	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509152	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT2105396	hsa-miR-583	CLIP-seq
MIRT2624172	hsa-miR-297	CLIP-seq
MIRT2624173	hsa-miR-3924	CLIP-seq
MIRT2624174	hsa-miR-567	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
NFKB1	Activation	20385226
RELA	Activation	20385226

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	IDA	10025957
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009409	Process	Response to cold	IBA	21873635
GO:0010917	Process	Negative regulation of mitochondrial membrane potential	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	10025957
GO:0035356	Process	Cellular triglyceride homeostasis	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045177	Component	Apical part of cell	IEA
GO:0046324	Process	Regulation of glucose import	IEA
GO:0048839	Process	Inner ear development	IEA
GO:0051562	Process	Negative regulation of mitochondrial calcium ion concentration	IEA
GO:0070997	Process	Neuron death	IEA
GO:1902600	Process	Proton transmembrane transport	TAS

MIM	HGNC	e!Ensembl
613725	21065	ENSG00000153291

Protein

UniProt ID

O95847

Protein name

Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27)

Protein function

Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, s

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00153	Mito_carr	16 → 120	Mitochondrial carrier protein	Family
PF00153	Mito_carr	123 → 222	Mitochondrial carrier protein	Family
PF00153	Mito_carr	225 → 320	Mitochondrial carrier protein	Family

Tissue specificity

TISSUE SPECIFICITY: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal cord, corpus callosum and substantia nigra. {ECO:0000269|PubMed:10025957}.

Sequence

MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD
GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS
EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI
LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL
VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM
TPWSMVFWLTYEKIREMSGVSPF

Sequence length

323

Interactions

View interactions

	Reactome
			The fatty acid cycling model The proton buffering model

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21332312, 17066476

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	36877954
Alzheimer Disease	Associate	30425186
Frontotemporal Dementia	Associate	30425186
Lung Neoplasms	Associate	36877954
Mitochondrial complex I deficiency	Inhibit	22427795
Neoplasms	Associate	25154973, 32053908
Neuroblastoma	Associate	22427795
Neurodegenerative Diseases	Associate	30425186

SLC25A27 (solute carrier family 25 member 27)