Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9473
Gene name Gene Name - the full gene name approved by the HGNC.	Thymocyte selection associated family member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	THEMIS2
Synonyms (NCBI Gene) Gene synonyms aliases	C1orf38, ICB-1, ICB1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p35.3

Show/Hide all(2)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004216	hsa-miR-197-3p	Microarray	16822819
MIRT017480	hsa-miR-335-5p	Microarray	18185580

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007155	Process	Cell adhesion	TAS	9563507
GO:0050852	Process	T cell receptor signaling pathway	IBA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050864	Process	Regulation of B cell activation	IEA
GO:0050864	Process	Regulation of B cell activation	ISS

MIM	HGNC	e!Ensembl
617856	16839	ENSG00000130775

Protein

UniProt ID

Q5TEJ8

Protein name

Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2)

Protein function

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activa

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12736	CABIT	18 → 243	Cell-cycle sustaining, positive selection,	Domain
PF12736	CABIT	267 → 520	Cell-cycle sustaining, positive selection,	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1. {ECO:0000269|PubMed:9563507}.

Sequence

MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCLSTGDLIKVTQVRLQKV
VCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQSSKQLPTCFMSTHRIVTE
GRVVTEDQLLMLEAVVMHLGIRSARCVLGMEGQQVILHLPLSQKGPFWTWEPSAPRTLLQ
VLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHMRRTIVKIPSTLEVDVEDVTASSRH
VHFIKPLLLSEVLAWEGPFPLSMEILEVPEGRPIFLSPWVGSLQKGQRLCVYGLASPPWR
VLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTAYDLLGAFQPGRPLRVVATKDCEGERE
ENPEFTSLAVGDRLEVLGPGQAHGAQGSDVDVLVCQRLSDQAGEDEEEECKEEAESPERV
LLPFHFPGSFVEEMSDSRRYSLADLTAQFSLPCEVKVVAKDTSHPTDPLTSFLGLRLEEK
ITEPFLVVSLDSEPGMCFEIPPRWLDLTVVKAKGQPDLPEGSLPIATVEELTDTFYYRLR
KLPACEIQAPPPRPPKNQGLSKQRRHSSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKD
GSSTYSKIPAHRKGHRPAKPQRQDLDDDEHDYEEILEQFQKTI

Sequence length

643

Interactions

View interactions

THEMIS2 (thymocyte selection associated family member 2)