Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9472
Gene name Gene Name - the full gene name approved by the HGNC.	A-kinase anchoring protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AKAP6
Synonyms (NCBI Gene) Gene synonyms aliases	ADAP100, ADAP6, AKAP100, PRKA6, mAKAP
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q12
Summary Summary of gene provided in NCBI Entrez Gene.	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene

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miRTarBase ID	miRNA	Experiments	Reference
MIRT689624	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT689623	hsa-miR-3929	HITS-CLIP	23313552
MIRT689622	hsa-miR-4419b	HITS-CLIP	23313552
MIRT689621	hsa-miR-4478	HITS-CLIP	23313552
MIRT689614	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT689620	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT689619	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT689618	hsa-miR-4695-3p	HITS-CLIP	23313552
MIRT689617	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT689616	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT689615	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT689614	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT689613	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT689612	hsa-miR-7641	HITS-CLIP	23313552
MIRT689611	hsa-miR-548s	HITS-CLIP	23313552
MIRT689610	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT689609	hsa-miR-588	HITS-CLIP	23313552
MIRT689608	hsa-miR-4435	HITS-CLIP	23313552
MIRT689607	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT689606	hsa-miR-5096	HITS-CLIP	23313552
MIRT689605	hsa-miR-1303	HITS-CLIP	23313552
MIRT512360	hsa-miR-4311	PAR-CLIP	23446348
MIRT512359	hsa-miR-1276	PAR-CLIP	23446348
MIRT512358	hsa-miR-583	PAR-CLIP	23446348
MIRT512357	hsa-miR-7974	PAR-CLIP	23446348
MIRT512356	hsa-miR-4687-3p	PAR-CLIP	23446348
MIRT512355	hsa-miR-1257	PAR-CLIP	23446348
MIRT689624	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT689623	hsa-miR-3929	HITS-CLIP	23313552
MIRT689622	hsa-miR-4419b	HITS-CLIP	23313552
MIRT689621	hsa-miR-4478	HITS-CLIP	23313552
MIRT689614	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT689620	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT689619	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT689618	hsa-miR-4695-3p	HITS-CLIP	23313552
MIRT689617	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT689616	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT689615	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT689614	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT689613	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT689612	hsa-miR-7641	HITS-CLIP	23313552
MIRT689611	hsa-miR-548s	HITS-CLIP	23313552
MIRT689610	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT689609	hsa-miR-588	HITS-CLIP	23313552
MIRT689608	hsa-miR-4435	HITS-CLIP	23313552
MIRT689607	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT689606	hsa-miR-5096	HITS-CLIP	23313552
MIRT689605	hsa-miR-1303	HITS-CLIP	23313552
MIRT512360	hsa-miR-4311	PAR-CLIP	23446348
MIRT512359	hsa-miR-1276	PAR-CLIP	23446348
MIRT512358	hsa-miR-583	PAR-CLIP	23446348
MIRT512357	hsa-miR-7974	PAR-CLIP	23446348
MIRT512356	hsa-miR-4687-3p	PAR-CLIP	23446348
MIRT512355	hsa-miR-1257	PAR-CLIP	23446348
MIRT775919	hsa-miR-1207-5p	CLIP-seq
MIRT775920	hsa-miR-1224-5p	CLIP-seq
MIRT775921	hsa-miR-1237	CLIP-seq
MIRT775922	hsa-miR-2276	CLIP-seq
MIRT775923	hsa-miR-2909	CLIP-seq
MIRT775924	hsa-miR-3065-5p	CLIP-seq
MIRT775925	hsa-miR-3158-3p	CLIP-seq
MIRT775926	hsa-miR-3179	CLIP-seq
MIRT775927	hsa-miR-3194-3p	CLIP-seq
MIRT775928	hsa-miR-3614-3p	CLIP-seq
MIRT775929	hsa-miR-3616-3p	CLIP-seq
MIRT775930	hsa-miR-3915	CLIP-seq
MIRT775931	hsa-miR-3928	CLIP-seq
MIRT775932	hsa-miR-4261	CLIP-seq
MIRT775933	hsa-miR-4278	CLIP-seq
MIRT775934	hsa-miR-4303	CLIP-seq
MIRT775935	hsa-miR-4326	CLIP-seq
MIRT775936	hsa-miR-4436a	CLIP-seq
MIRT775937	hsa-miR-4436b-3p	CLIP-seq
MIRT775938	hsa-miR-4471	CLIP-seq
MIRT775939	hsa-miR-4496	CLIP-seq
MIRT775940	hsa-miR-4649-3p	CLIP-seq
MIRT775941	hsa-miR-4689	CLIP-seq
MIRT775942	hsa-miR-4694-3p	CLIP-seq
MIRT775943	hsa-miR-4694-5p	CLIP-seq
MIRT775944	hsa-miR-4721	CLIP-seq
MIRT775945	hsa-miR-4763-3p	CLIP-seq
MIRT775946	hsa-miR-4772-3p	CLIP-seq
MIRT775947	hsa-miR-513a-3p	CLIP-seq
MIRT775948	hsa-miR-522	CLIP-seq
MIRT775949	hsa-miR-548a-3p	CLIP-seq
MIRT775950	hsa-miR-548e	CLIP-seq
MIRT775951	hsa-miR-548f	CLIP-seq
MIRT775952	hsa-miR-579	CLIP-seq
MIRT775953	hsa-miR-628-5p	CLIP-seq
MIRT775954	hsa-miR-646	CLIP-seq
MIRT1920237	hsa-miR-124	CLIP-seq
MIRT1920238	hsa-miR-3120-3p	CLIP-seq
MIRT1920239	hsa-miR-4708-3p	CLIP-seq
MIRT1920240	hsa-miR-506	CLIP-seq
MIRT1928964	hsa-miR-1272	CLIP-seq
MIRT1928965	hsa-miR-143	CLIP-seq
MIRT1928966	hsa-miR-193a-3p	CLIP-seq
MIRT1928967	hsa-miR-193b	CLIP-seq
MIRT1928968	hsa-miR-203	CLIP-seq
MIRT1928969	hsa-miR-3176	CLIP-seq
MIRT1928970	hsa-miR-3689a-3p	CLIP-seq
MIRT1928971	hsa-miR-3689c	CLIP-seq
MIRT1928972	hsa-miR-3922-3p	CLIP-seq
MIRT1928973	hsa-miR-4691-5p	CLIP-seq
MIRT1928974	hsa-miR-4770	CLIP-seq
MIRT1928975	hsa-miR-548ae	CLIP-seq
MIRT1928976	hsa-miR-548aj	CLIP-seq
MIRT1928977	hsa-miR-548am	CLIP-seq
MIRT1928978	hsa-miR-548x	CLIP-seq
MIRT1928979	hsa-miR-582-3p	CLIP-seq
MIRT1928980	hsa-miR-607	CLIP-seq
MIRT2169658	hsa-miR-1343	CLIP-seq
MIRT2169659	hsa-miR-2116	CLIP-seq
MIRT2169660	hsa-miR-375	CLIP-seq
MIRT2169661	hsa-miR-4273	CLIP-seq
MIRT2169662	hsa-miR-4640-5p	CLIP-seq
MIRT2169663	hsa-miR-4677-5p	CLIP-seq
MIRT2169664	hsa-miR-4726-5p	CLIP-seq
MIRT2169665	hsa-miR-4793-5p	CLIP-seq
MIRT2169666	hsa-miR-616	CLIP-seq
MIRT2169667	hsa-miR-656	CLIP-seq
MIRT2426150	hsa-miR-4528	CLIP-seq
MIRT2426151	hsa-miR-4789-5p	CLIP-seq
MIRT2426152	hsa-miR-499-3p	CLIP-seq
MIRT2426153	hsa-miR-499a-3p	CLIP-seq
MIRT2169666	hsa-miR-616	CLIP-seq
MIRT2443489	hsa-miR-223	CLIP-seq
MIRT2443490	hsa-miR-369-3p	CLIP-seq
MIRT2443491	hsa-miR-380	CLIP-seq
MIRT2443492	hsa-miR-3975	CLIP-seq
MIRT2443493	hsa-miR-4495	CLIP-seq
MIRT2443494	hsa-miR-4659a-3p	CLIP-seq
MIRT2443495	hsa-miR-4659b-3p	CLIP-seq
MIRT2443496	hsa-miR-4697-3p	CLIP-seq
MIRT2443497	hsa-miR-4778-3p	CLIP-seq
MIRT2443498	hsa-miR-592	CLIP-seq
MIRT2443499	hsa-miR-597	CLIP-seq
MIRT2443500	hsa-miR-599	CLIP-seq

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001508	Process	Action potential	IDA	11299204
GO:0005515	Function	Protein binding	IPI	17923693
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	10413680
GO:0005635	Component	Nuclear envelope	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005901	Component	Caveola	ISS
GO:0006605	Process	Protein targeting	NAS	7721854, 10413680
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS	16177794
GO:0008179	Function	Adenylate cyclase binding	ISS
GO:0010739	Process	Positive regulation of protein kinase A signaling	ISS
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISS
GO:0010959	Process	Regulation of metal ion transport	IEA
GO:0014701	Component	Junctional sarcoplasmic reticulum membrane	ISS
GO:0014704	Component	Intercalated disc	ISS	9679148
GO:0016020	Component	Membrane	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IBA
GO:0016529	Component	Sarcoplasmic reticulum	IDA	7721854, 10830164
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0030307	Process	Positive regulation of cell growth	ISS	16177794
GO:0030315	Component	T-tubule	ISS	9679148
GO:0031965	Component	Nuclear membrane	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0034237	Function	Protein kinase A regulatory subunit binding	ISS
GO:0034704	Component	Calcium channel complex	IDA	10830164
GO:0043495	Function	Protein-membrane adaptor activity	ISS	10413680
GO:0044325	Function	Transmembrane transporter binding	IBA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0044325	Function	Transmembrane transporter binding	IPI	10830164
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11590243
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0051018	Function	Protein kinase A binding	IBA
GO:0051018	Function	Protein kinase A binding	NAS	10413680
GO:0051018	Function	Protein kinase A binding	TAS	10830164
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	ISS
GO:0060090	Function	Molecular adaptor activity	ISS
GO:0060306	Process	Regulation of membrane repolarization	IDA	11299204
GO:0061051	Process	Positive regulation of cell growth involved in cardiac muscle cell development	ISS
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	ISS
GO:0071320	Process	Cellular response to cAMP	IDA	11299204
GO:0071345	Process	Cellular response to cytokine stimulus	ISS	16177794
GO:0141161	Process	Regulation of cAMP/PKA signal transduction	ISS
GO:1901381	Process	Positive regulation of potassium ion transmembrane transport	IDA	11299204
GO:1904064	Process	Positive regulation of cation transmembrane transport	IEA

MIM	HGNC	e!Ensembl
604691	376	ENSG00000151320

Protein

UniProt ID

Q13023

Protein name

A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP)

Protein function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00435	Spectrin	779 → 884	Spectrin repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in cardiac and skeletal muscle, followed by brain.

Sequence

MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHT
GADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQ
IHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGL
GDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLS
VDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPE
MSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISS
SLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSK
HKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG
ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEK
IEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVE
EEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNG
LLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKV
EALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLV
RQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASI
LRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLN
VIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPG
YDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVL
TKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEM
CLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKV
GDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLR
GFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLS
LLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISV
SSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSI
NEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNV
SCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKN
ELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENN
GNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENL
GSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPT
EKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCN
CEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHR
PIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACV
EGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQE
RAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDL
SLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR

Sequence length

2319

Interactions

View interactions

Show/Hide Unknown Diseases (12)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Ankylosing Spondylitis	Ankylosing spondylitis	N/A	N/A	GWAS
Anorexia	Anorexia nervosa	N/A	N/A	GWAS
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Bipolar Disorder	Bipolar disorder	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes or prostate cancer (pleiotropy), Type 2 diabetes (PheCode 250.2), Type 2 diabetes	N/A	N/A	GWAS
Glioma	Glioma	N/A	N/A	GWAS
Heart Failure	Heart failure	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myopia	Myopia	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	36291125
Anorexia Nervosa	Associate	27483138
Astrocytoma	Associate	31759389
Carcinoma Ovarian Epithelial	Associate	29979793
Cardiovascular Diseases	Associate	29600899
Celiac Disease	Associate	27483138
Cognitive Dysfunction	Associate	36291125
Diabetes Mellitus Type 2	Associate	33290408
Glioma	Associate	31759389
Heart Diseases	Associate	29600899
Insulin Resistance	Associate	23628382
Neoplasms Adipose Tissue	Associate	23628382
Prostatic Neoplasms	Associate	33290408
Ventricular Remodeling	Associate	29600899

AKAP6 (A-kinase anchoring protein 6)