RASAL2 (RAS protein activator like 2)

Gene

• Entrez ID: 9462
• Gene name: RAS protein activator like 2
• Gene symbol: RASAL2
• Synonyms (NCBI Gene): NGAP
• Chromosome: 1
• Chromosome location: 1q25.2
• Summary: This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027468	hsa-miR-98-5p	Microarray	19088304
MIRT029026	hsa-miR-26b-5p	Microarray	19088304
MIRT048987	hsa-miR-92a-3p	qRT-PCR	23622248
MIRT048987	hsa-miR-92a-3p	CLASH	23622248
MIRT048603	hsa-miR-99a-5p	CLASH	23622248
MIRT045969	hsa-miR-125b-5p	CLASH	23622248
MIRT038984	hsa-miR-15a-3p	CLASH	23622248
MIRT053439	hsa-miR-203a-3p	Microarray	23807165
MIRT654446	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654445	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654444	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654443	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT654442	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT469544	hsa-miR-5583-3p	PAR-CLIP	23592263
MIRT469543	hsa-miR-511-3p	PAR-CLIP	23592263
MIRT469542	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT654446	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT654445	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT654444	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT654443	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT654442	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT469544	hsa-miR-5583-3p	PAR-CLIP	23592263
MIRT469543	hsa-miR-511-3p	PAR-CLIP	23592263
MIRT469542	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT739876	hsa-miR-1229	CLIP-seq
MIRT1292007	hsa-miR-127-5p	CLIP-seq
MIRT1292008	hsa-miR-1297	CLIP-seq
MIRT1292009	hsa-miR-140-3p	CLIP-seq
MIRT739875	hsa-miR-197	CLIP-seq
MIRT1292010	hsa-miR-26a	CLIP-seq
MIRT1292011	hsa-miR-26b	CLIP-seq
MIRT1292012	hsa-miR-29a	CLIP-seq
MIRT1292013	hsa-miR-29b	CLIP-seq
MIRT1292014	hsa-miR-29c	CLIP-seq
MIRT1292015	hsa-miR-3125	CLIP-seq
MIRT1292016	hsa-miR-3145-3p	CLIP-seq
MIRT1292017	hsa-miR-3184	CLIP-seq
MIRT1292018	hsa-miR-3185	CLIP-seq
MIRT1292019	hsa-miR-345	CLIP-seq
MIRT1292020	hsa-miR-3691-3p	CLIP-seq
MIRT1292021	hsa-miR-3916	CLIP-seq
MIRT1292022	hsa-miR-3936	CLIP-seq
MIRT1292023	hsa-miR-410	CLIP-seq
MIRT1292024	hsa-miR-423-5p	CLIP-seq
MIRT1292025	hsa-miR-4256	CLIP-seq
MIRT1292026	hsa-miR-4271	CLIP-seq
MIRT1292027	hsa-miR-4282	CLIP-seq
MIRT739877	hsa-miR-4433	CLIP-seq
MIRT739878	hsa-miR-4459	CLIP-seq
MIRT1292028	hsa-miR-4461	CLIP-seq
MIRT1292029	hsa-miR-4465	CLIP-seq
MIRT1292030	hsa-miR-4517	CLIP-seq
MIRT1292031	hsa-miR-4662a-3p	CLIP-seq
MIRT1292032	hsa-miR-4686	CLIP-seq
MIRT1292033	hsa-miR-4698	CLIP-seq
MIRT1292034	hsa-miR-4699-3p	CLIP-seq
MIRT1292035	hsa-miR-4718	CLIP-seq
MIRT1292036	hsa-miR-4725-3p	CLIP-seq
MIRT1292037	hsa-miR-4731-5p	CLIP-seq
MIRT1292038	hsa-miR-4762-3p	CLIP-seq
MIRT739879	hsa-miR-4768-3p	CLIP-seq
MIRT1292039	hsa-miR-4777-3p	CLIP-seq
MIRT1292040	hsa-miR-4789-3p	CLIP-seq
MIRT1292041	hsa-miR-498	CLIP-seq
MIRT1292042	hsa-miR-555	CLIP-seq
MIRT1292007	hsa-miR-127-5p	CLIP-seq
MIRT1292043	hsa-miR-130a	CLIP-seq
MIRT1292044	hsa-miR-130b	CLIP-seq
MIRT1292045	hsa-miR-203	CLIP-seq
MIRT1292046	hsa-miR-218	CLIP-seq
MIRT1292047	hsa-miR-25	CLIP-seq
MIRT1292048	hsa-miR-27a	CLIP-seq
MIRT1292049	hsa-miR-27b	CLIP-seq
MIRT1292050	hsa-miR-301a	CLIP-seq
MIRT1292051	hsa-miR-301b	CLIP-seq
MIRT1292052	hsa-miR-3120-3p	CLIP-seq
MIRT1292015	hsa-miR-3125	CLIP-seq
MIRT1292053	hsa-miR-3126-5p	CLIP-seq
MIRT1292054	hsa-miR-3146	CLIP-seq
MIRT1292055	hsa-miR-32	CLIP-seq
MIRT1292056	hsa-miR-323-3p	CLIP-seq
MIRT1292057	hsa-miR-340	CLIP-seq
MIRT1292058	hsa-miR-342-3p	CLIP-seq
MIRT1292019	hsa-miR-345	CLIP-seq
MIRT1292059	hsa-miR-34a	CLIP-seq
MIRT1292060	hsa-miR-34c-5p	CLIP-seq
MIRT1292061	hsa-miR-3614-5p	CLIP-seq
MIRT1292062	hsa-miR-361-5p	CLIP-seq
MIRT1292063	hsa-miR-3617	CLIP-seq
MIRT1292064	hsa-miR-363	CLIP-seq
MIRT1292065	hsa-miR-3666	CLIP-seq
MIRT1292066	hsa-miR-3669	CLIP-seq
MIRT1292067	hsa-miR-367	CLIP-seq
MIRT1292068	hsa-miR-3680	CLIP-seq
MIRT1292069	hsa-miR-371-5p	CLIP-seq
MIRT1292021	hsa-miR-3916	CLIP-seq
MIRT1292070	hsa-miR-3942-5p	CLIP-seq
MIRT1292025	hsa-miR-4256	CLIP-seq
MIRT1292071	hsa-miR-4261	CLIP-seq
MIRT1292072	hsa-miR-4295	CLIP-seq
MIRT1292073	hsa-miR-4325	CLIP-seq
MIRT1292074	hsa-miR-4419a	CLIP-seq
MIRT1292075	hsa-miR-4477a	CLIP-seq
MIRT1292076	hsa-miR-449a	CLIP-seq
MIRT1292077	hsa-miR-449b	CLIP-seq
MIRT1292078	hsa-miR-4510	CLIP-seq
MIRT1292030	hsa-miR-4517	CLIP-seq
MIRT1292079	hsa-miR-454	CLIP-seq
MIRT1292080	hsa-miR-4652-3p	CLIP-seq
MIRT1292032	hsa-miR-4686	CLIP-seq
MIRT1292081	hsa-miR-4695-3p	CLIP-seq
MIRT1292082	hsa-miR-4696	CLIP-seq
MIRT1292083	hsa-miR-4703-5p	CLIP-seq
MIRT1292084	hsa-miR-4716-5p	CLIP-seq
MIRT1292035	hsa-miR-4718	CLIP-seq
MIRT1292085	hsa-miR-4726-3p	CLIP-seq
MIRT1292086	hsa-miR-4728-3p	CLIP-seq
MIRT1292087	hsa-miR-4753-3p	CLIP-seq
MIRT1292038	hsa-miR-4762-3p	CLIP-seq
MIRT1292088	hsa-miR-4773	CLIP-seq
MIRT1292089	hsa-miR-4778-5p	CLIP-seq
MIRT1292090	hsa-miR-4802-5p	CLIP-seq
MIRT1292091	hsa-miR-495	CLIP-seq
MIRT1292092	hsa-miR-513a-5p	CLIP-seq
MIRT1292093	hsa-miR-519a	CLIP-seq
MIRT1292094	hsa-miR-519b-3p	CLIP-seq
MIRT1292095	hsa-miR-519c-3p	CLIP-seq
MIRT1292096	hsa-miR-582-5p	CLIP-seq
MIRT1292097	hsa-miR-636	CLIP-seq
MIRT1292098	hsa-miR-641	CLIP-seq
MIRT1292099	hsa-miR-656	CLIP-seq
MIRT1292100	hsa-miR-676	CLIP-seq
MIRT1292101	hsa-miR-92a	CLIP-seq
MIRT1292102	hsa-miR-92b	CLIP-seq
MIRT1292103	hsa-miR-944	CLIP-seq
MIRT2086837	hsa-miR-128	CLIP-seq
MIRT2086838	hsa-miR-151-3p	CLIP-seq
MIRT2086839	hsa-miR-2113	CLIP-seq
MIRT2086840	hsa-miR-326	CLIP-seq
MIRT2086841	hsa-miR-330-5p	CLIP-seq
MIRT1292063	hsa-miR-3617	CLIP-seq
MIRT2086842	hsa-miR-3686	CLIP-seq
MIRT2086843	hsa-miR-4254	CLIP-seq
MIRT1292027	hsa-miR-4282	CLIP-seq
MIRT2086844	hsa-miR-4491	CLIP-seq
MIRT2086845	hsa-miR-4511	CLIP-seq
MIRT1292080	hsa-miR-4652-3p	CLIP-seq
MIRT2086846	hsa-miR-4657	CLIP-seq
MIRT1292082	hsa-miR-4696	CLIP-seq
MIRT2086847	hsa-miR-4719	CLIP-seq
MIRT2086848	hsa-miR-4722-5p	CLIP-seq
MIRT739879	hsa-miR-4768-3p	CLIP-seq
MIRT2086849	hsa-miR-4778-3p	CLIP-seq
MIRT1292089	hsa-miR-4778-5p	CLIP-seq
MIRT2086850	hsa-miR-493	CLIP-seq
MIRT1292098	hsa-miR-641	CLIP-seq
MIRT1292016	hsa-miR-3145-3p	CLIP-seq
MIRT2311746	hsa-miR-3689a-5p	CLIP-seq
MIRT2311747	hsa-miR-3689b	CLIP-seq
MIRT2311748	hsa-miR-3689e	CLIP-seq
MIRT2311749	hsa-miR-3689f	CLIP-seq
MIRT1292080	hsa-miR-4652-3p	CLIP-seq
MIRT2311750	hsa-miR-216a	CLIP-seq
MIRT2311751	hsa-miR-216b	CLIP-seq
MIRT2311752	hsa-miR-374a	CLIP-seq
MIRT2311753	hsa-miR-374b	CLIP-seq
MIRT2393499	hsa-miR-1193	CLIP-seq
MIRT2393500	hsa-miR-135a	CLIP-seq
MIRT2393501	hsa-miR-135b	CLIP-seq
MIRT2393502	hsa-miR-3143	CLIP-seq
MIRT2393503	hsa-miR-3545-3p	CLIP-seq
MIRT2393504	hsa-miR-4473	CLIP-seq
MIRT2393505	hsa-miR-512-3p	CLIP-seq
MIRT2393506	hsa-miR-520f	CLIP-seq
MIRT2393507	hsa-miR-543	CLIP-seq
MIRT2393508	hsa-miR-609	CLIP-seq
MIRT2432449	hsa-miR-4520a-3p	CLIP-seq
MIRT2608189	hsa-miR-1305	CLIP-seq
MIRT2608190	hsa-miR-194	CLIP-seq
MIRT2608191	hsa-miR-3065-5p	CLIP-seq
MIRT1292015	hsa-miR-3125	CLIP-seq
MIRT2608192	hsa-miR-3160-5p	CLIP-seq
MIRT1292058	hsa-miR-342-3p	CLIP-seq
MIRT1292066	hsa-miR-3669	CLIP-seq
MIRT2608193	hsa-miR-3682-5p	CLIP-seq
MIRT2608194	hsa-miR-3685	CLIP-seq
MIRT2608195	hsa-miR-377	CLIP-seq
MIRT2608196	hsa-miR-383	CLIP-seq
MIRT1292021	hsa-miR-3916	CLIP-seq
MIRT2608197	hsa-miR-421	CLIP-seq
MIRT2608198	hsa-miR-4418	CLIP-seq
MIRT2608199	hsa-miR-4661-5p	CLIP-seq
MIRT1292081	hsa-miR-4695-3p	CLIP-seq
MIRT2608200	hsa-miR-4709-5p	CLIP-seq
MIRT2608201	hsa-miR-4772-5p	CLIP-seq
MIRT2608202	hsa-miR-4799-5p	CLIP-seq
MIRT2608203	hsa-miR-486-5p	CLIP-seq
MIRT2608204	hsa-miR-494	CLIP-seq
MIRT2608205	hsa-miR-509-3-5p	CLIP-seq
MIRT2608206	hsa-miR-509-5p	CLIP-seq
MIRT2393506	hsa-miR-520f	CLIP-seq
MIRT2608207	hsa-miR-563	CLIP-seq
MIRT2608208	hsa-miR-570	CLIP-seq
MIRT2608190	hsa-miR-194	CLIP-seq
MIRT2608192	hsa-miR-3160-5p	CLIP-seq
MIRT2689357	hsa-miR-3658	CLIP-seq
MIRT2608193	hsa-miR-3682-5p	CLIP-seq
MIRT2608194	hsa-miR-3685	CLIP-seq
MIRT2608195	hsa-miR-377	CLIP-seq
MIRT2608196	hsa-miR-383	CLIP-seq
MIRT2608198	hsa-miR-4418	CLIP-seq
MIRT2689358	hsa-miR-4693-3p	CLIP-seq
MIRT2608200	hsa-miR-4709-5p	CLIP-seq
MIRT2608201	hsa-miR-4772-5p	CLIP-seq
MIRT2608203	hsa-miR-486-5p	CLIP-seq
MIRT2608204	hsa-miR-494	CLIP-seq
MIRT2608205	hsa-miR-509-3-5p	CLIP-seq
MIRT2608206	hsa-miR-509-5p	CLIP-seq
MIRT2393506	hsa-miR-520f	CLIP-seq
MIRT2608207	hsa-miR-563	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002021	Process	Response to dietary excess	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS	9877179
GO:0005515	Function	Protein binding	IPI	14743216, 18985028, 25416956, 32296183, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9877179
GO:0009749	Process	Response to glucose	IEA
GO:0010467	Process	Gene expression	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0060612	Process	Adipose tissue development	IEA
GO:1902531	Process	Regulation of intracellular signal transduction	IBA
GO:2000257	Process	Regulation of protein activation cascade	IEA

Other IDs

• MIM: 606136
• HGNC: 9874
• e!Ensembl: ENSG00000075391

Protein

• UniProt ID: Q9UJF2
• Protein name: Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
• Protein function: Inhibitory regulator of the Ras-cyclic AMP pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	169 → 269	C2 domain	Domain
  PF00616	RasGAP	348 → 420	GTPase-activator protein for Ras-like GTPase	Family
  PF00616	RasGAP	414 → 519	GTPase-activator protein for Ras-like GTPase	Family
  PF12004	DUF3498	609 → 1110	Domain of unknown function (DUF3498)	Family

• Sequence:

  MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKL
  DRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSI
  LGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKD
  LAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKK
  KDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQ
  YKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC
  GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSEL
  IDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLR
  FLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHE
  WGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA
  KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHK
  LKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQV
  EHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLS
  FQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQ
  SEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSM
  SVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA
  AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ
  MQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQK
  IIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC

• Sequence length: 1139

Pathways

KEGG:

Ras signaling pathway

Reactome:

Regulation of RAS by GAPs

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Prostate cancer	Uncertain significance	rs193921085	RCV000149161

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	28167613
Carcinoma	Associate	24718460
Carcinoma Non Small Cell Lung	Associate	33300072, 34193694
Carcinoma Pancreatic Ductal	Associate	34863899
Carcinoma Pancreatic Ductal	Stimulate	35844783
Neoplasm Metastasis	Associate	28167613
Neoplasm Metastasis	Inhibit	34193694
Neoplasms	Stimulate	33300072
Neoplasms	Inhibit	34193694
Neoplasms	Associate	35844783
Obesity	Associate	23950976
Ovarian Neoplasms	Associate	34193694
Thyroid Neoplasms	Associate	24718460, 32737449
Triple Negative Breast Neoplasms	Associate	34168046, 34193694