SIGLEC6 (sialic acid binding Ig like lectin 6)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
946
Gene name Gene Name - the full gene name approved by the HGNC.
Sialic acid binding Ig like lectin 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SIGLEC6
Synonyms (NCBI Gene) Gene synonyms aliases
CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT2327636 hsa-miR-1283 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956
GO:0005576 Component Extracellular region IEA
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604405 10875 ENSG00000105492
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O43699
Protein name Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Protein function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 34 → 142 Immunoglobulin V-set domain Domain
PF00047 ig 150 → 230 Immunoglobulin domain Domain
PF07679 I-set 253 → 336 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
Sequence
Sequence length 453
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37974107
Colorectal Neoplasms Associate 30294327, 34975867
Gestational Trophoblastic Disease Associate 23089140
HELLP Syndrome Associate 20541258
Infections Associate 34147404
Leukemia Myeloid Acute Associate 16728277
Lupus Erythematosus Systemic Associate 26808113
Neoplasms Associate 34147404
Nevus Associate 23089140
Pre Eclampsia Associate 20541258