ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)

Gene

• Entrez ID: 9459
• Gene name: Rac/Cdc42 guanine nucleotide exchange factor 6
• Gene symbol: ARHGEF6
• Synonyms (NCBI Gene): COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX
• Chromosome: X
• Chromosome location: Xq26.3
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007134	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT037230	hsa-miR-877-5p	CLASH	23622248
MIRT483456	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT483455	hsa-miR-5197-3p	HITS-CLIP	23824327
MIRT483454	hsa-miR-6758-5p	HITS-CLIP	23824327
MIRT483453	hsa-miR-6856-5p	HITS-CLIP	23824327
MIRT483452	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT483451	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT539123	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT483450	hsa-miR-1253	HITS-CLIP	23824327
MIRT483449	hsa-miR-4419a	HITS-CLIP	23824327
MIRT483448	hsa-miR-4510	HITS-CLIP	23824327
MIRT483447	hsa-miR-6127	HITS-CLIP	23824327
MIRT483446	hsa-miR-6129	HITS-CLIP	23824327
MIRT483445	hsa-miR-6130	HITS-CLIP	23824327
MIRT483444	hsa-miR-6133	HITS-CLIP	23824327
MIRT483443	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT483441	hsa-miR-4306	HITS-CLIP	23824327
MIRT483442	hsa-miR-4644	HITS-CLIP	23824327
MIRT483440	hsa-miR-6731-5p	HITS-CLIP	23824327
MIRT483439	hsa-miR-8085	HITS-CLIP	23824327
MIRT483456	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	22012620
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	22012620
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT483449	hsa-miR-4419a	PAR-CLIP	22012620
MIRT483448	hsa-miR-4510	PAR-CLIP	22012620
MIRT483447	hsa-miR-6127	PAR-CLIP	22012620
MIRT483446	hsa-miR-6129	PAR-CLIP	22012620
MIRT483445	hsa-miR-6130	PAR-CLIP	22012620
MIRT483444	hsa-miR-6133	PAR-CLIP	22012620
MIRT483443	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT483441	hsa-miR-4306	PAR-CLIP	22012620
MIRT483442	hsa-miR-4644	PAR-CLIP	22012620
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT483439	hsa-miR-8085	PAR-CLIP	22012620
MIRT483456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	23592263
MIRT483449	hsa-miR-4419a	PAR-CLIP	23592263
MIRT483448	hsa-miR-4510	PAR-CLIP	23592263
MIRT483447	hsa-miR-6127	PAR-CLIP	23592263
MIRT483446	hsa-miR-6129	PAR-CLIP	23592263
MIRT483445	hsa-miR-6130	PAR-CLIP	23592263
MIRT483444	hsa-miR-6133	PAR-CLIP	23592263
MIRT483443	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT483441	hsa-miR-4306	PAR-CLIP	23592263
MIRT483442	hsa-miR-4644	PAR-CLIP	23592263
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483439	hsa-miR-8085	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	27292025
MIRT483443	hsa-miR-185-5p	PAR-CLIP	27292025
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	27292025
MIRT483441	hsa-miR-4306	PAR-CLIP	27292025
MIRT483449	hsa-miR-4419a	PAR-CLIP	27292025
MIRT483448	hsa-miR-4510	PAR-CLIP	27292025
MIRT483442	hsa-miR-4644	PAR-CLIP	27292025
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	27292025
MIRT483447	hsa-miR-6127	PAR-CLIP	27292025
MIRT483446	hsa-miR-6129	PAR-CLIP	27292025
MIRT483445	hsa-miR-6130	PAR-CLIP	27292025
MIRT483444	hsa-miR-6133	PAR-CLIP	27292025
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	27292025
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	27292025
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	27292025
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	27292025
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	27292025
MIRT483439	hsa-miR-8085	PAR-CLIP	27292025
MIRT483456	hsa-miR-888-5p	PAR-CLIP	27292025
MIRT483456	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT483455	hsa-miR-5197-3p	HITS-CLIP	23824327
MIRT483454	hsa-miR-6758-5p	HITS-CLIP	23824327
MIRT483453	hsa-miR-6856-5p	HITS-CLIP	23824327
MIRT483452	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT483451	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT539123	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT483450	hsa-miR-1253	HITS-CLIP	23824327
MIRT483449	hsa-miR-4419a	HITS-CLIP	23824327
MIRT483448	hsa-miR-4510	HITS-CLIP	23824327
MIRT483447	hsa-miR-6127	HITS-CLIP	23824327
MIRT483446	hsa-miR-6129	HITS-CLIP	23824327
MIRT483445	hsa-miR-6130	HITS-CLIP	23824327
MIRT483444	hsa-miR-6133	HITS-CLIP	23824327
MIRT483443	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT483441	hsa-miR-4306	HITS-CLIP	23824327
MIRT483442	hsa-miR-4644	HITS-CLIP	23824327
MIRT483440	hsa-miR-6731-5p	HITS-CLIP	23824327
MIRT483439	hsa-miR-8085	HITS-CLIP	23824327
MIRT483456	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	22012620
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	22012620
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT483449	hsa-miR-4419a	PAR-CLIP	22012620
MIRT483448	hsa-miR-4510	PAR-CLIP	22012620
MIRT483447	hsa-miR-6127	PAR-CLIP	22012620
MIRT483446	hsa-miR-6129	PAR-CLIP	22012620
MIRT483445	hsa-miR-6130	PAR-CLIP	22012620
MIRT483444	hsa-miR-6133	PAR-CLIP	22012620
MIRT483443	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT483441	hsa-miR-4306	PAR-CLIP	22012620
MIRT483442	hsa-miR-4644	PAR-CLIP	22012620
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT483439	hsa-miR-8085	PAR-CLIP	22012620
MIRT483456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	23592263
MIRT483449	hsa-miR-4419a	PAR-CLIP	23592263
MIRT483448	hsa-miR-4510	PAR-CLIP	23592263
MIRT483447	hsa-miR-6127	PAR-CLIP	23592263
MIRT483446	hsa-miR-6129	PAR-CLIP	23592263
MIRT483445	hsa-miR-6130	PAR-CLIP	23592263
MIRT483444	hsa-miR-6133	PAR-CLIP	23592263
MIRT483443	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT483441	hsa-miR-4306	PAR-CLIP	23592263
MIRT483442	hsa-miR-4644	PAR-CLIP	23592263
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483439	hsa-miR-8085	PAR-CLIP	23592263
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT795986	hsa-miR-1252	CLIP-seq
MIRT795987	hsa-miR-125a-5p	CLIP-seq
MIRT795988	hsa-miR-125b	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT795992	hsa-miR-185	CLIP-seq
MIRT795993	hsa-miR-186	CLIP-seq
MIRT795994	hsa-miR-1910	CLIP-seq
MIRT795995	hsa-miR-1911	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795997	hsa-miR-2052	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT796001	hsa-miR-3140-5p	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT796003	hsa-miR-338-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT796005	hsa-miR-3616-3p	CLIP-seq
MIRT796006	hsa-miR-3661	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT796008	hsa-miR-378g	CLIP-seq
MIRT796009	hsa-miR-425	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT796011	hsa-miR-4291	CLIP-seq
MIRT796012	hsa-miR-4319	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796014	hsa-miR-4424	CLIP-seq
MIRT796015	hsa-miR-4427	CLIP-seq
MIRT796016	hsa-miR-4437	CLIP-seq
MIRT796017	hsa-miR-4445	CLIP-seq
MIRT796018	hsa-miR-4481	CLIP-seq
MIRT796019	hsa-miR-4501	CLIP-seq
MIRT796020	hsa-miR-4523	CLIP-seq
MIRT796021	hsa-miR-4530	CLIP-seq
MIRT796022	hsa-miR-455-3p	CLIP-seq
MIRT796023	hsa-miR-4666-5p	CLIP-seq
MIRT796024	hsa-miR-4674	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT796027	hsa-miR-4682	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT796030	hsa-miR-4721	CLIP-seq
MIRT796031	hsa-miR-4745-5p	CLIP-seq
MIRT796032	hsa-miR-4758-5p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT796037	hsa-miR-520a-5p	CLIP-seq
MIRT796038	hsa-miR-525-5p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT796041	hsa-miR-631	CLIP-seq
MIRT1545513	hsa-miR-1246	CLIP-seq
MIRT1545514	hsa-miR-198	CLIP-seq
MIRT1545515	hsa-miR-3134	CLIP-seq
MIRT1545516	hsa-miR-4534	CLIP-seq
MIRT1545517	hsa-miR-4712-5p	CLIP-seq
MIRT1545518	hsa-miR-628-5p	CLIP-seq
MIRT1545519	hsa-miR-770-5p	CLIP-seq
MIRT1545520	hsa-miR-936	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT1935106	hsa-miR-146b-3p	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT1935107	hsa-miR-3187-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT1935110	hsa-miR-4435	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT1935112	hsa-miR-4701-5p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT1935113	hsa-miR-548s	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT1935115	hsa-miR-588	CLIP-seq
MIRT2175048	hsa-miR-103a	CLIP-seq
MIRT2175049	hsa-miR-105	CLIP-seq
MIRT2175050	hsa-miR-107	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT795987	hsa-miR-125a-5p	CLIP-seq
MIRT795988	hsa-miR-125b	CLIP-seq
MIRT2175051	hsa-miR-1260	CLIP-seq
MIRT2175052	hsa-miR-1260b	CLIP-seq
MIRT2175053	hsa-miR-1280	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT2175054	hsa-miR-1913	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT2175055	hsa-miR-3166	CLIP-seq
MIRT2175056	hsa-miR-324-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT796008	hsa-miR-378g	CLIP-seq
MIRT2175057	hsa-miR-3934	CLIP-seq
MIRT2175058	hsa-miR-3944-5p	CLIP-seq
MIRT796009	hsa-miR-425	CLIP-seq
MIRT2175059	hsa-miR-4265	CLIP-seq
MIRT2175060	hsa-miR-4271	CLIP-seq
MIRT2175061	hsa-miR-4296	CLIP-seq
MIRT2175062	hsa-miR-4313	CLIP-seq
MIRT796012	hsa-miR-4319	CLIP-seq
MIRT2175063	hsa-miR-4322	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT2175064	hsa-miR-4417	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796014	hsa-miR-4424	CLIP-seq
MIRT796016	hsa-miR-4437	CLIP-seq
MIRT2175065	hsa-miR-4533	CLIP-seq
MIRT2175066	hsa-miR-4640-5p	CLIP-seq
MIRT796023	hsa-miR-4666-5p	CLIP-seq
MIRT796024	hsa-miR-4674	CLIP-seq
MIRT796027	hsa-miR-4682	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT2175067	hsa-miR-4725-3p	CLIP-seq
MIRT2175068	hsa-miR-4726-5p	CLIP-seq
MIRT2175069	hsa-miR-4727-5p	CLIP-seq
MIRT2175070	hsa-miR-4747-5p	CLIP-seq
MIRT2175071	hsa-miR-4789-3p	CLIP-seq
MIRT2175072	hsa-miR-501-3p	CLIP-seq
MIRT2175073	hsa-miR-502-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT2175074	hsa-miR-532-3p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT2175075	hsa-miR-548a-5p	CLIP-seq
MIRT2175076	hsa-miR-548ab	CLIP-seq
MIRT2175077	hsa-miR-548ak	CLIP-seq
MIRT2175078	hsa-miR-548b-5p	CLIP-seq
MIRT2175079	hsa-miR-548c-5p	CLIP-seq
MIRT2175080	hsa-miR-548d-5p	CLIP-seq
MIRT2175081	hsa-miR-548h	CLIP-seq
MIRT2175082	hsa-miR-548i	CLIP-seq
MIRT2175083	hsa-miR-548j	CLIP-seq
MIRT2175084	hsa-miR-548w	CLIP-seq
MIRT2175085	hsa-miR-548y	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT2175086	hsa-miR-559	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT2175051	hsa-miR-1260	CLIP-seq
MIRT2175052	hsa-miR-1260b	CLIP-seq
MIRT2175053	hsa-miR-1280	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT2384442	hsa-miR-330-3p	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT2175074	hsa-miR-532-3p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT2175075	hsa-miR-548a-5p	CLIP-seq
MIRT2175076	hsa-miR-548ab	CLIP-seq
MIRT2175077	hsa-miR-548ak	CLIP-seq
MIRT2175078	hsa-miR-548b-5p	CLIP-seq
MIRT2175079	hsa-miR-548c-5p	CLIP-seq
MIRT2175080	hsa-miR-548d-5p	CLIP-seq
MIRT2175081	hsa-miR-548h	CLIP-seq
MIRT2175082	hsa-miR-548i	CLIP-seq
MIRT2175083	hsa-miR-548j	CLIP-seq
MIRT2175084	hsa-miR-548w	CLIP-seq
MIRT2175085	hsa-miR-548y	CLIP-seq
MIRT2175086	hsa-miR-559	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2443961	hsa-miR-450b-5p	CLIP-seq
MIRT2443962	hsa-miR-4729	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT2443964	hsa-miR-518a-5p	CLIP-seq
MIRT2443965	hsa-miR-527	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT2478258	hsa-miR-1297	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT2478259	hsa-miR-139-5p	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT2478260	hsa-miR-2681	CLIP-seq
MIRT2478261	hsa-miR-2682	CLIP-seq
MIRT2478262	hsa-miR-26a	CLIP-seq
MIRT2478263	hsa-miR-26b	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT2478264	hsa-miR-3126-5p	CLIP-seq
MIRT2478265	hsa-miR-3153	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT2478266	hsa-miR-320a	CLIP-seq
MIRT2478267	hsa-miR-320b	CLIP-seq
MIRT2478268	hsa-miR-320c	CLIP-seq
MIRT2478269	hsa-miR-320d	CLIP-seq
MIRT2478270	hsa-miR-320e	CLIP-seq
MIRT2478271	hsa-miR-325	CLIP-seq
MIRT2478272	hsa-miR-329	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2478273	hsa-miR-362-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT2478274	hsa-miR-3672	CLIP-seq
MIRT2175057	hsa-miR-3934	CLIP-seq
MIRT2478275	hsa-miR-3941	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT2478276	hsa-miR-4268	CLIP-seq
MIRT2478277	hsa-miR-4328	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT2478278	hsa-miR-4429	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT2478279	hsa-miR-4465	CLIP-seq
MIRT2478280	hsa-miR-4484	CLIP-seq
MIRT2478281	hsa-miR-449c	CLIP-seq
MIRT2478282	hsa-miR-466	CLIP-seq
MIRT2478283	hsa-miR-4668-5p	CLIP-seq
MIRT2478284	hsa-miR-4672	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT2478285	hsa-miR-4680-3p	CLIP-seq
MIRT2478286	hsa-miR-4704-5p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT2478287	hsa-miR-4731-5p	CLIP-seq
MIRT2478288	hsa-miR-4761-3p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT2478289	hsa-miR-4775	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT2478290	hsa-miR-4799-5p	CLIP-seq
MIRT2478291	hsa-miR-490-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT2478292	hsa-miR-578	CLIP-seq
MIRT2478293	hsa-miR-582-5p	CLIP-seq
MIRT2478294	hsa-miR-590-3p	CLIP-seq
MIRT2478295	hsa-miR-603	CLIP-seq
MIRT2478296	hsa-miR-607	CLIP-seq
MIRT2478297	hsa-miR-626	CLIP-seq
MIRT2478298	hsa-miR-628-3p	CLIP-seq
MIRT2478299	hsa-miR-637	CLIP-seq
MIRT2478300	hsa-miR-642b	CLIP-seq
MIRT2478301	hsa-miR-652	CLIP-seq
MIRT2478302	hsa-miR-940	CLIP-seq
MIRT2478303	hsa-miR-943	CLIP-seq
MIRT795986	hsa-miR-1252	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT2675337	hsa-miR-1321	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT2478259	hsa-miR-139-5p	CLIP-seq
MIRT2675338	hsa-miR-155	CLIP-seq
MIRT1545514	hsa-miR-198	CLIP-seq
MIRT795997	hsa-miR-2052	CLIP-seq
MIRT2675339	hsa-miR-219-5p	CLIP-seq
MIRT2478260	hsa-miR-2681	CLIP-seq
MIRT2478261	hsa-miR-2682	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT2478264	hsa-miR-3126-5p	CLIP-seq
MIRT2478265	hsa-miR-3153	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT2675340	hsa-miR-3184	CLIP-seq
MIRT2478266	hsa-miR-320a	CLIP-seq
MIRT2478267	hsa-miR-320b	CLIP-seq
MIRT2478268	hsa-miR-320c	CLIP-seq
MIRT2478269	hsa-miR-320d	CLIP-seq
MIRT2478271	hsa-miR-325	CLIP-seq
MIRT2478272	hsa-miR-329	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2675341	hsa-miR-3607-5p	CLIP-seq
MIRT2675342	hsa-miR-3612	CLIP-seq
MIRT2478273	hsa-miR-362-3p	CLIP-seq
MIRT2478274	hsa-miR-3672	CLIP-seq
MIRT2478275	hsa-miR-3941	CLIP-seq
MIRT2675343	hsa-miR-423-5p	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT2478276	hsa-miR-4268	CLIP-seq
MIRT2478277	hsa-miR-4328	CLIP-seq
MIRT2478278	hsa-miR-4429	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT796017	hsa-miR-4445	CLIP-seq
MIRT2478280	hsa-miR-4484	CLIP-seq
MIRT2478281	hsa-miR-449c	CLIP-seq
MIRT2478282	hsa-miR-466	CLIP-seq
MIRT2478283	hsa-miR-4668-5p	CLIP-seq
MIRT2478284	hsa-miR-4672	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT2478285	hsa-miR-4680-3p	CLIP-seq
MIRT2478286	hsa-miR-4704-5p	CLIP-seq
MIRT1545517	hsa-miR-4712-5p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT2675344	hsa-miR-4739	CLIP-seq
MIRT2675345	hsa-miR-4756-5p	CLIP-seq
MIRT2478288	hsa-miR-4761-3p	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT2478289	hsa-miR-4775	CLIP-seq
MIRT2675346	hsa-miR-4778-3p	CLIP-seq
MIRT2675347	hsa-miR-4782-3p	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT2478290	hsa-miR-4799-5p	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT2675348	hsa-miR-548aa	CLIP-seq
MIRT2478292	hsa-miR-578	CLIP-seq
MIRT2478293	hsa-miR-582-5p	CLIP-seq
MIRT2478294	hsa-miR-590-3p	CLIP-seq
MIRT2675349	hsa-miR-601	CLIP-seq
MIRT2478295	hsa-miR-603	CLIP-seq
MIRT2478297	hsa-miR-626	CLIP-seq
MIRT2478298	hsa-miR-628-3p	CLIP-seq
MIRT2478300	hsa-miR-642b	CLIP-seq
MIRT2675350	hsa-miR-649	CLIP-seq
MIRT2675351	hsa-miR-650	CLIP-seq
MIRT2478301	hsa-miR-652	CLIP-seq
MIRT1545519	hsa-miR-770-5p	CLIP-seq
MIRT1545520	hsa-miR-936	CLIP-seq
MIRT2478302	hsa-miR-940	CLIP-seq
MIRT2478303	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	NAS	11017088
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	NAS	9582122
GO:0005515	Function	Protein binding	IPI	11864573, 16374509, 16983070, 21295525, 21900206, 23455922, 31980649, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0006915	Process	Apoptotic process	NAS	11564864
GO:0007254	Process	JNK cascade	NAS	11564864
GO:0030027	Component	Lamellipodium	IBA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030032	Process	Lamellipodium assembly	IBA
GO:0030032	Process	Lamellipodium assembly	IEA
GO:0030032	Process	Lamellipodium assembly	ISS
GO:0042995	Component	Cell projection	IEA

Other IDs

• MIM: 300267
• HGNC: 685
• e!Ensembl: ENSG00000129675

Protein

• UniProt ID: Q15052
• Protein name: Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
• Protein function: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
• PDB: 1UJY, 1WYR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	1 → 112	Calponin homology (CH) domain	Domain
  PF16615	RhoGEF67_u1	114 → 160		Disordered
  PF07653	SH3_2	164 → 217	Variant SH3 domain	Domain
  PF00621	RhoGEF	245 → 419	RhoGEF domain	Domain
  PF00169	PH	443 → 548	PH domain	Domain
  PF16614	RhoGEF67_u2	570 → 678		Disordered
  PF16523	betaPIX_CC	681 → 769	betaPIX coiled coil	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
  QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
  RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
  VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
  YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
  QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
  ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
  LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
  LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
  EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
  RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
  KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
  LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP

• Sequence length: 776

Pathways

KEGG:

Regulation of actin cytoskeleton
Pancreatic cancer

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
ARHGEF6-associated Neurodevelopmental disorder	Uncertain significance	rs375084147	RCV002275049
ARHGEF6-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs35106300, rs138342895, rs12008084, rs75329154, rs2522148728, rs2522424517, rs766570806, rs762641850, rs140322310, rs145081421, rs140378313, rs770180249	RCV003952564 RCV003952565 RCV003905111 RCV003927762 RCV003427810 RCV003410608 RCV003931686 RCV003962063 RCV003902448 RCV003960148 RCV003943008 RCV003413787
Familial cancer of breast	Benign; Likely benign	rs140322310	RCV005900606
Genetic developmental and epileptic encephalopathy	Benign; Likely benign	rs35106300	RCV005621878
History of neurodevelopmental disorder	Conflicting classifications of pathogenicity	rs147131853	RCV000721042
Intellectual disability	Benign; Likely benign	rs35106300, rs757760891	RCV005621877 RCV001251679
Intellectual disability, X-linked 46	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs1426557239, rs2076312974, rs35106300, rs147131853, rs140322310, rs375084147	RCV001329326 RCV001329325 RCV000609668 RCV000990954 RCV002221232 RCV000990953
Non-syndromic X-linked intellectual disability	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	rs75329154, rs968152666, rs751450350, rs757215282, rs770569536, rs775186031, rs1057515778	RCV000263759 RCV000344658 RCV000327777 RCV000289652 RCV000348922 RCV000310001 RCV000364644
See cases	Uncertain significance	rs761576293	RCV001197148
Thyroid cancer, nonmedullary, 1	Benign	rs148319648	RCV005906552
Uveal melanoma	Benign; Likely benign	rs140322310	RCV005900607
Vanishing white matter disease	Uncertain significance	rs2076230593	RCV001253004

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	37058762
Autism Spectrum Disorder	Associate	34069769
Colitis Ulcerative	Associate	25479423
Colorectal Neoplasms	Associate	24504536
Crohn Disease	Associate	25479423
Inflammatory Bowel Diseases	Associate	25479423
Intellectual Disability	Associate	23871722
Leukemia Myeloid Acute	Associate	37027440
Mental Retardation X Linked	Associate	17304053, 9783701
Neoplasms	Associate	37058762
Progressive hearing loss stapes fixation	Associate	35202564