FHL5 (four and a half LIM domains 5)

Gene

• Entrez ID: 9457
• Gene name: Four and a half LIM domains 5
• Gene symbol: FHL5
• Synonyms (NCBI Gene): 1700027G07Rik, ACT, FHL-5, dJ393D12.2
• Chromosome: 6
• Chromosome location: 6q16.1
• Summary: The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029004	hsa-miR-26b-5p	Microarray	19088304
MIRT1995496	hsa-miR-218	CLIP-seq
MIRT1995497	hsa-miR-3140-3p	CLIP-seq
MIRT1995498	hsa-miR-636	CLIP-seq
MIRT1995499	hsa-miR-3138	CLIP-seq
MIRT1995500	hsa-miR-4318	CLIP-seq
MIRT1995501	hsa-miR-4800-5p	CLIP-seq
MIRT2229500	hsa-miR-1238	CLIP-seq
MIRT2229501	hsa-miR-3616-3p	CLIP-seq
MIRT2229502	hsa-miR-4302	CLIP-seq
MIRT2229503	hsa-miR-4519	CLIP-seq
MIRT2229504	hsa-miR-4721	CLIP-seq
MIRT2229505	hsa-miR-759	CLIP-seq
MIRT2229506	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREM	Unknown	16687568
NFIC	Activation	16565071

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 23088713, 25910212, 26871637, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030018	Component	Z disc	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 605126
• HGNC: 17371
• e!Ensembl: ENSG00000112214

Protein

• UniProt ID: Q5TD97
• Protein name: Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis)
• Protein function: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
• PDB: 1X68
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	41 → 98	LIM domain	Domain
  PF00412	LIM	102 → 159	LIM domain	Domain
  PF00412	LIM	163 → 218	LIM domain	Domain
  PF00412	LIM	222 → 279	LIM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis-specific (at protein level). {ECO:0000269|PubMed:11327716}.
• Sequence:

  MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDR
  HWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKG
  NYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQ
  LWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICF
  QDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

• Sequence length: 284