Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9456
Gene name Gene Name - the full gene name approved by the HGNC.	Homer scaffold protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HOMER1
Synonyms (NCBI Gene) Gene synonyms aliases	HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q14.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Show/Hide all(154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032118	hsa-let-7d-5p	Sequencing	20371350
MIRT042276	hsa-miR-484	CLASH	23622248
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614955	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	27418678
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	27418678
MIRT614957	hsa-miR-2113	HITS-CLIP	27418678
MIRT614957	hsa-miR-2113	HITS-CLIP	27418678
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT733515	hsa-miR-1200	Microarray	34164896
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614961	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT614960	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT614959	hsa-miR-6074	HITS-CLIP	23824327
MIRT614958	hsa-miR-4272	HITS-CLIP	23824327
MIRT614957	hsa-miR-2113	HITS-CLIP	23824327
MIRT614956	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT614955	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT1052525	hsa-miR-1278	CLIP-seq
MIRT1052526	hsa-miR-1284	CLIP-seq
MIRT1052527	hsa-miR-150	CLIP-seq
MIRT1052528	hsa-miR-192	CLIP-seq
MIRT1052529	hsa-miR-2053	CLIP-seq
MIRT1052530	hsa-miR-215	CLIP-seq
MIRT1052531	hsa-miR-300	CLIP-seq
MIRT1052532	hsa-miR-3074-3p	CLIP-seq
MIRT1052533	hsa-miR-3145-3p	CLIP-seq
MIRT1052534	hsa-miR-3148	CLIP-seq
MIRT1052535	hsa-miR-338-3p	CLIP-seq
MIRT1052536	hsa-miR-33a	CLIP-seq
MIRT1052537	hsa-miR-33b	CLIP-seq
MIRT1052538	hsa-miR-3613-3p	CLIP-seq
MIRT1052539	hsa-miR-3671	CLIP-seq
MIRT1052540	hsa-miR-3674	CLIP-seq
MIRT1052541	hsa-miR-3689a-5p	CLIP-seq
MIRT1052542	hsa-miR-3689b	CLIP-seq
MIRT1052543	hsa-miR-3689d	CLIP-seq
MIRT1052544	hsa-miR-3689e	CLIP-seq
MIRT1052545	hsa-miR-3689f	CLIP-seq
MIRT1052546	hsa-miR-3690	CLIP-seq
MIRT1052547	hsa-miR-381	CLIP-seq
MIRT1052548	hsa-miR-3921	CLIP-seq
MIRT1052549	hsa-miR-3926	CLIP-seq
MIRT1052550	hsa-miR-410	CLIP-seq
MIRT1052551	hsa-miR-4254	CLIP-seq
MIRT1052552	hsa-miR-4287	CLIP-seq
MIRT1052553	hsa-miR-4303	CLIP-seq
MIRT1052554	hsa-miR-4305	CLIP-seq
MIRT1052555	hsa-miR-4318	CLIP-seq
MIRT1052556	hsa-miR-4469	CLIP-seq
MIRT1052557	hsa-miR-4501	CLIP-seq
MIRT1052558	hsa-miR-4511	CLIP-seq
MIRT1052559	hsa-miR-4530	CLIP-seq
MIRT1052560	hsa-miR-4653-5p	CLIP-seq
MIRT1052561	hsa-miR-4666-3p	CLIP-seq
MIRT1052562	hsa-miR-4680-5p	CLIP-seq
MIRT1052563	hsa-miR-4685-3p	CLIP-seq
MIRT1052564	hsa-miR-4693-5p	CLIP-seq
MIRT1052565	hsa-miR-4698	CLIP-seq
MIRT1052566	hsa-miR-4703-3p	CLIP-seq
MIRT1052567	hsa-miR-4705	CLIP-seq
MIRT1052568	hsa-miR-4713-5p	CLIP-seq
MIRT1052569	hsa-miR-4718	CLIP-seq
MIRT1052570	hsa-miR-4742-3p	CLIP-seq
MIRT1052571	hsa-miR-4764-5p	CLIP-seq
MIRT1052572	hsa-miR-4765	CLIP-seq
MIRT1052573	hsa-miR-4796-5p	CLIP-seq
MIRT1052574	hsa-miR-4799-5p	CLIP-seq
MIRT1052575	hsa-miR-4802-3p	CLIP-seq
MIRT1052576	hsa-miR-4802-5p	CLIP-seq
MIRT1052577	hsa-miR-518a-5p	CLIP-seq
MIRT1052578	hsa-miR-527	CLIP-seq
MIRT1052579	hsa-miR-532-3p	CLIP-seq
MIRT1052580	hsa-miR-548s	CLIP-seq
MIRT1052581	hsa-miR-569	CLIP-seq
MIRT1052582	hsa-miR-578	CLIP-seq
MIRT1052583	hsa-miR-592	CLIP-seq
MIRT1052584	hsa-miR-595	CLIP-seq
MIRT1052585	hsa-miR-597	CLIP-seq
MIRT1052586	hsa-miR-765	CLIP-seq
MIRT1052587	hsa-miR-873	CLIP-seq
MIRT1052588	hsa-miR-889	CLIP-seq
MIRT1052589	hsa-miR-892a	CLIP-seq
MIRT1052590	hsa-miR-944	CLIP-seq
MIRT1920484	hsa-miR-361-5p	CLIP-seq
MIRT1920485	hsa-miR-3919	CLIP-seq
MIRT1920486	hsa-miR-4756-3p	CLIP-seq
MIRT1920487	hsa-miR-539	CLIP-seq
MIRT1920484	hsa-miR-361-5p	CLIP-seq
MIRT1920485	hsa-miR-3919	CLIP-seq
MIRT1920486	hsa-miR-4756-3p	CLIP-seq
MIRT1920487	hsa-miR-539	CLIP-seq
MIRT2011900	hsa-miR-1297	CLIP-seq
MIRT2011901	hsa-miR-26a	CLIP-seq
MIRT2011902	hsa-miR-26b	CLIP-seq
MIRT2011903	hsa-miR-3591-3p	CLIP-seq
MIRT2011904	hsa-miR-3614-5p	CLIP-seq
MIRT1052540	hsa-miR-3674	CLIP-seq
MIRT2011905	hsa-miR-4465	CLIP-seq
MIRT1052566	hsa-miR-4703-3p	CLIP-seq
MIRT2244215	hsa-miR-223	CLIP-seq
MIRT2244216	hsa-miR-759	CLIP-seq
MIRT2244217	hsa-miR-888	CLIP-seq
MIRT2244218	hsa-miR-935	CLIP-seq
MIRT2429685	hsa-miR-19a	CLIP-seq
MIRT2429686	hsa-miR-19b	CLIP-seq
MIRT1052533	hsa-miR-3145-3p	CLIP-seq
MIRT1052541	hsa-miR-3689a-5p	CLIP-seq
MIRT1052542	hsa-miR-3689b	CLIP-seq
MIRT1052544	hsa-miR-3689e	CLIP-seq
MIRT1052545	hsa-miR-3689f	CLIP-seq
MIRT2547153	hsa-miR-1207-3p	CLIP-seq
MIRT2547154	hsa-miR-3171	CLIP-seq
MIRT2547155	hsa-miR-383	CLIP-seq
MIRT2547156	hsa-miR-3909	CLIP-seq
MIRT2547157	hsa-miR-4760-5p	CLIP-seq
MIRT2547158	hsa-miR-4772-5p	CLIP-seq
MIRT2547156	hsa-miR-3909	CLIP-seq
MIRT2547157	hsa-miR-4760-5p	CLIP-seq

Show/Hide all(45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003009	Process	Skeletal muscle contraction	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18218901, 19447967, 25416956, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007206	Process	Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	TAS	9808459
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	9808458
GO:0009967	Process	Positive regulation of signal transduction	IC	14505576
GO:0014069	Component	Postsynaptic density	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0030018	Component	Z disc	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IBA
GO:0035256	Function	G protein-coupled glutamate receptor binding	IBA
GO:0035256	Function	G protein-coupled glutamate receptor binding	IEA
GO:0035591	Function	Signaling adaptor activity	IC	14505576
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043034	Component	Costamere	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044309	Component	Neuron spine	ISS
GO:0044325	Function	Transmembrane transporter binding	IPI	14505576
GO:0045177	Component	Apical part of cell	IEA
GO:0045202	Component	Synapse	IEA
GO:0048148	Process	Behavioral response to cocaine	IEA
GO:0048741	Process	Skeletal muscle fiber development	IEA
GO:0051262	Process	Protein tetramerization	ISS
GO:0051592	Process	Response to calcium ion	IDA	14505576
GO:0051928	Process	Positive regulation of calcium ion transport	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	ISS
GO:0090279	Process	Regulation of calcium ion import	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:1902950	Process	Regulation of dendritic spine maintenance	ISS
GO:2001256	Process	Regulation of store-operated calcium entry	IBA
GO:2001256	Process	Regulation of store-operated calcium entry	IEA
GO:2001256	Process	Regulation of store-operated calcium entry	TAS	14505576

MIM	HGNC	e!Ensembl
604798	17512	ENSG00000152413

Protein

UniProt ID

Q86YM7

Protein name

Homer protein homolog 1 (Homer-1)

Protein function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surfac

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00568	WH1	1 → 107	WH1 domain	Domain

Sequence

MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST
ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK
MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS
KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN
AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD
LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS

Sequence length

354

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Glutamatergic synapse		Neurexins and neuroligins

HOMER1 (homer scaffold protein 1)