LY86 (lymphocyte antigen 86)

Gene

• Entrez ID: 9450
• Gene name: Lymphocyte antigen 86
• Gene symbol: LY86
• Synonyms (NCBI Gene): MD-1, MD1, MMD-1, dJ80N2.1
• Chromosome: 6
• Chromosome location: 6p25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1123049	hsa-miR-1207-3p	CLIP-seq
MIRT1123050	hsa-miR-28-5p	CLIP-seq
MIRT1123051	hsa-miR-3139	CLIP-seq
MIRT1123052	hsa-miR-3689d	CLIP-seq
MIRT1123053	hsa-miR-4279	CLIP-seq
MIRT1123054	hsa-miR-432	CLIP-seq
MIRT1123055	hsa-miR-4443	CLIP-seq
MIRT1123056	hsa-miR-4453	CLIP-seq
MIRT1123057	hsa-miR-4538	CLIP-seq
MIRT1123058	hsa-miR-4708-5p	CLIP-seq
MIRT1123059	hsa-miR-662	CLIP-seq
MIRT1123060	hsa-miR-708	CLIP-seq
MIRT1123049	hsa-miR-1207-3p	CLIP-seq
MIRT1123052	hsa-miR-3689d	CLIP-seq
MIRT1123054	hsa-miR-432	CLIP-seq
MIRT1123055	hsa-miR-4443	CLIP-seq
MIRT1123056	hsa-miR-4453	CLIP-seq
MIRT1123057	hsa-miR-4538	CLIP-seq
MIRT1123058	hsa-miR-4708-5p	CLIP-seq
MIRT1123059	hsa-miR-662	CLIP-seq
MIRT2265243	hsa-miR-181a	CLIP-seq
MIRT2265244	hsa-miR-181b	CLIP-seq
MIRT2265245	hsa-miR-181c	CLIP-seq
MIRT2265246	hsa-miR-181d	CLIP-seq
MIRT1123050	hsa-miR-28-5p	CLIP-seq
MIRT1123051	hsa-miR-3139	CLIP-seq
MIRT1123052	hsa-miR-3689d	CLIP-seq
MIRT2265247	hsa-miR-4262	CLIP-seq
MIRT1123054	hsa-miR-432	CLIP-seq
MIRT1123055	hsa-miR-4443	CLIP-seq
MIRT1123056	hsa-miR-4453	CLIP-seq
MIRT1123057	hsa-miR-4538	CLIP-seq
MIRT2265248	hsa-miR-4652-5p	CLIP-seq
MIRT1123058	hsa-miR-4708-5p	CLIP-seq
MIRT2265249	hsa-miR-542-5p	CLIP-seq
MIRT1123059	hsa-miR-662	CLIP-seq
MIRT1123060	hsa-miR-708	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	21857663, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IBA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IEA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IGI	10880523
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA

Other IDs

• MIM: 605241
• HGNC: 16837
• e!Ensembl: ENSG00000112799

Protein

• UniProt ID: O95711
• Protein name: Lymphocyte antigen 86 (Ly-86) (Protein MD-1)
• Protein function: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
• PDB: 3B2D
• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in B-cells, monocytes and tonsil.
• Sequence:

  MKGFTATLFLWTLIFPSCSGGGGGKAWPTHVVCSDSGLEVLYQSCDPLQDFGFSVEKCSK
  QLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPICEAALPKFSFCGRRKGEQI
  YYAGPVNNPEFTIPQGEYQVLLELYTEKRSTVACANATIMCS

• Sequence length: 162

Pathways

Reactome:

Toll Like Receptor 4 (TLR4) Cascade