Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9448
Gene name	Mitogen-activated protein kinase kinase kinase kinase 4
Gene symbol	MAP4K4
Synonyms (NCBI Gene)	FLH21957HEL-S-31HGKMEKKK4NIK
Chromosome	2
Chromosome location	2q11.2
Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of

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SNP ID	Visualize variation	Clinical significance	Consequence
rs781410462	G>A	Likely-pathogenic	Coding sequence variant, missense variant

347

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052966	hsa-miR-520e	Luciferase reporter assayqRT-PCRWestern blot	22105365
MIRT053693	hsa-miR-181a-5p	Microarray	22942087
MIRT053751	hsa-miR-31-5p	ImmunoblotImmunohistochemistryLuciferase reporter assayqRT-PCR	22948084
MIRT437487	hsa-miR-141-3p	PANC-1	24013097
MIRT735663	hsa-miR-582-3p	Immunohistochemistry (IHC)	33510968
MIRT755629	rno-miR-547-3p	Luciferase reporter assayWestern blottingqRT-PCR	36045396
MIRT1129534	hsa-miR-1200	CLIP-seq
MIRT1129535	hsa-miR-1289	CLIP-seq
MIRT1129536	hsa-miR-139-3p	CLIP-seq
MIRT1129537	hsa-miR-299-3p	CLIP-seq
MIRT1129538	hsa-miR-300	CLIP-seq
MIRT1129539	hsa-miR-3074-5p	CLIP-seq
MIRT1129540	hsa-miR-3124-3p	CLIP-seq
MIRT1129541	hsa-miR-3176	CLIP-seq
MIRT1129542	hsa-miR-3187-3p	CLIP-seq
MIRT1129543	hsa-miR-3198	CLIP-seq
MIRT1129544	hsa-miR-3591-5p	CLIP-seq
MIRT1129545	hsa-miR-3649	CLIP-seq
MIRT1129546	hsa-miR-3663-5p	CLIP-seq
MIRT1129547	hsa-miR-370	CLIP-seq
MIRT1129548	hsa-miR-381	CLIP-seq
MIRT1129549	hsa-miR-3922-3p	CLIP-seq
MIRT1129550	hsa-miR-4277	CLIP-seq
MIRT1129551	hsa-miR-4280	CLIP-seq
MIRT1129552	hsa-miR-4294	CLIP-seq
MIRT1129553	hsa-miR-4309	CLIP-seq
MIRT1129554	hsa-miR-4318	CLIP-seq
MIRT1129555	hsa-miR-4324	CLIP-seq
MIRT1129556	hsa-miR-4329	CLIP-seq
MIRT1129557	hsa-miR-4435	CLIP-seq
MIRT1129558	hsa-miR-4466	CLIP-seq
MIRT1129559	hsa-miR-4491	CLIP-seq
MIRT1129560	hsa-miR-4494	CLIP-seq
MIRT1129561	hsa-miR-4504	CLIP-seq
MIRT1129562	hsa-miR-4520a-3p	CLIP-seq
MIRT1129563	hsa-miR-4528	CLIP-seq
MIRT1129564	hsa-miR-4529-5p	CLIP-seq
MIRT1129565	hsa-miR-4536	CLIP-seq
MIRT1129566	hsa-miR-4657	CLIP-seq
MIRT1129567	hsa-miR-4666-3p	CLIP-seq
MIRT1129568	hsa-miR-4682	CLIP-seq
MIRT1129569	hsa-miR-4684-3p	CLIP-seq
MIRT1129570	hsa-miR-4698	CLIP-seq
MIRT1129571	hsa-miR-4701-5p	CLIP-seq
MIRT1129572	hsa-miR-4763-5p	CLIP-seq
MIRT1129573	hsa-miR-4771	CLIP-seq
MIRT1129574	hsa-miR-4789-5p	CLIP-seq
MIRT1129575	hsa-miR-4802-3p	CLIP-seq
MIRT1129576	hsa-miR-501-5p	CLIP-seq
MIRT1129577	hsa-miR-542-3p	CLIP-seq
MIRT1129578	hsa-miR-544b	CLIP-seq
MIRT1129579	hsa-miR-548a-3p	CLIP-seq
MIRT1129580	hsa-miR-548e	CLIP-seq
MIRT1129581	hsa-miR-548f	CLIP-seq
MIRT1129582	hsa-miR-548n	CLIP-seq
MIRT1129583	hsa-miR-548s	CLIP-seq
MIRT1129584	hsa-miR-548t	CLIP-seq
MIRT1129585	hsa-miR-550a	CLIP-seq
MIRT1129586	hsa-miR-578	CLIP-seq
MIRT1129587	hsa-miR-581	CLIP-seq
MIRT1129588	hsa-miR-588	CLIP-seq
MIRT1129589	hsa-miR-675	CLIP-seq
MIRT1129590	hsa-miR-758	CLIP-seq
MIRT1129591	hsa-miR-933	CLIP-seq
MIRT1129592	hsa-miR-197	CLIP-seq
MIRT1129593	hsa-miR-3591-3p	CLIP-seq
MIRT1129594	hsa-miR-371b-3p	CLIP-seq
MIRT1129595	hsa-miR-759	CLIP-seq
MIRT1129596	hsa-miR-4762-5p	CLIP-seq
MIRT1129597	hsa-miR-4777-3p	CLIP-seq
MIRT1129598	hsa-miR-605	CLIP-seq
MIRT2036920	hsa-miR-1272	CLIP-seq
MIRT2036921	hsa-miR-1301	CLIP-seq
MIRT2036922	hsa-miR-1322	CLIP-seq
MIRT2036923	hsa-miR-145	CLIP-seq
MIRT2036924	hsa-miR-4659a-3p	CLIP-seq
MIRT2036925	hsa-miR-4659b-3p	CLIP-seq
MIRT2036926	hsa-miR-4660	CLIP-seq
MIRT2036927	hsa-miR-4756-3p	CLIP-seq
MIRT2036928	hsa-miR-5047	CLIP-seq
MIRT2036929	hsa-miR-548a-5p	CLIP-seq
MIRT2036930	hsa-miR-548ab	CLIP-seq
MIRT2036931	hsa-miR-548ak	CLIP-seq
MIRT2036932	hsa-miR-548b-5p	CLIP-seq
MIRT2036933	hsa-miR-548c-5p	CLIP-seq
MIRT2036934	hsa-miR-548d-5p	CLIP-seq
MIRT2036935	hsa-miR-548h	CLIP-seq
MIRT2036936	hsa-miR-548i	CLIP-seq
MIRT2036937	hsa-miR-548j	CLIP-seq
MIRT2036938	hsa-miR-548w	CLIP-seq
MIRT2036939	hsa-miR-548y	CLIP-seq
MIRT2036940	hsa-miR-559	CLIP-seq
MIRT2266984	hsa-miR-1181	CLIP-seq
MIRT2266985	hsa-miR-1206	CLIP-seq
MIRT2266986	hsa-miR-1226	CLIP-seq
MIRT2266987	hsa-miR-1250	CLIP-seq
MIRT2036920	hsa-miR-1272	CLIP-seq
MIRT2036921	hsa-miR-1301	CLIP-seq
MIRT2036922	hsa-miR-1322	CLIP-seq
MIRT2266988	hsa-miR-1324	CLIP-seq
MIRT2036923	hsa-miR-145	CLIP-seq
MIRT2266989	hsa-miR-200b	CLIP-seq
MIRT2266990	hsa-miR-200c	CLIP-seq
MIRT2266991	hsa-miR-29a	CLIP-seq
MIRT2266992	hsa-miR-29b	CLIP-seq
MIRT2266993	hsa-miR-29c	CLIP-seq
MIRT2266994	hsa-miR-3065-3p	CLIP-seq
MIRT2266995	hsa-miR-3125	CLIP-seq
MIRT2266996	hsa-miR-3157-3p	CLIP-seq
MIRT2266997	hsa-miR-3160-5p	CLIP-seq
MIRT2266998	hsa-miR-3173-3p	CLIP-seq
MIRT1129541	hsa-miR-3176	CLIP-seq
MIRT2266999	hsa-miR-3180-5p	CLIP-seq
MIRT1129542	hsa-miR-3187-3p	CLIP-seq
MIRT2267000	hsa-miR-3529	CLIP-seq
MIRT2267001	hsa-miR-3612	CLIP-seq
MIRT2267002	hsa-miR-3617	CLIP-seq
MIRT2267003	hsa-miR-3622a-3p	CLIP-seq
MIRT2267004	hsa-miR-3622b-3p	CLIP-seq
MIRT2267005	hsa-miR-379	CLIP-seq
MIRT2267006	hsa-miR-3916	CLIP-seq
MIRT1129549	hsa-miR-3922-3p	CLIP-seq
MIRT2267007	hsa-miR-3944-5p	CLIP-seq
MIRT2267008	hsa-miR-4252	CLIP-seq
MIRT2267009	hsa-miR-429	CLIP-seq
MIRT2267010	hsa-miR-4290	CLIP-seq
MIRT2267011	hsa-miR-4304	CLIP-seq
MIRT2267012	hsa-miR-4420	CLIP-seq
MIRT2267013	hsa-miR-4432	CLIP-seq
MIRT2267014	hsa-miR-4443	CLIP-seq
MIRT2267015	hsa-miR-4451	CLIP-seq
MIRT2267016	hsa-miR-4522	CLIP-seq
MIRT2267017	hsa-miR-4539	CLIP-seq
MIRT2267018	hsa-miR-4633-3p	CLIP-seq
MIRT2267019	hsa-miR-4635	CLIP-seq
MIRT2267020	hsa-miR-4650-3p	CLIP-seq
MIRT2036924	hsa-miR-4659a-3p	CLIP-seq
MIRT2036925	hsa-miR-4659b-3p	CLIP-seq
MIRT2036926	hsa-miR-4660	CLIP-seq
MIRT2267021	hsa-miR-4709-3p	CLIP-seq
MIRT2267022	hsa-miR-4711-5p	CLIP-seq
MIRT2267023	hsa-miR-4712-5p	CLIP-seq
MIRT2267024	hsa-miR-4774-5p	CLIP-seq
MIRT2267025	hsa-miR-4779	CLIP-seq
MIRT1129574	hsa-miR-4789-5p	CLIP-seq
MIRT2036928	hsa-miR-5047	CLIP-seq
MIRT2267026	hsa-miR-516b	CLIP-seq
MIRT2036929	hsa-miR-548a-5p	CLIP-seq
MIRT2036930	hsa-miR-548ab	CLIP-seq
MIRT2036931	hsa-miR-548ak	CLIP-seq
MIRT2036932	hsa-miR-548b-5p	CLIP-seq
MIRT2036933	hsa-miR-548c-5p	CLIP-seq
MIRT2036934	hsa-miR-548d-5p	CLIP-seq
MIRT2036935	hsa-miR-548h	CLIP-seq
MIRT2036936	hsa-miR-548i	CLIP-seq
MIRT2036937	hsa-miR-548j	CLIP-seq
MIRT2036938	hsa-miR-548w	CLIP-seq
MIRT2036939	hsa-miR-548y	CLIP-seq
MIRT2036940	hsa-miR-559	CLIP-seq
MIRT2267027	hsa-miR-609	CLIP-seq
MIRT2267028	hsa-miR-615-3p	CLIP-seq
MIRT2267029	hsa-miR-641	CLIP-seq
MIRT2267030	hsa-miR-650	CLIP-seq
MIRT2267031	hsa-miR-770-5p	CLIP-seq
MIRT2267032	hsa-miR-874	CLIP-seq
MIRT2390587	hsa-miR-4709-5p	CLIP-seq
MIRT2036921	hsa-miR-1301	CLIP-seq
MIRT2036926	hsa-miR-4660	CLIP-seq
MIRT2036928	hsa-miR-5047	CLIP-seq
MIRT2267018	hsa-miR-4633-3p	CLIP-seq
MIRT2453694	hsa-miR-1229	CLIP-seq
MIRT2453695	hsa-miR-3919	CLIP-seq
MIRT2036927	hsa-miR-4756-3p	CLIP-seq
MIRT2453696	hsa-miR-4797-5p	CLIP-seq
MIRT2566598	hsa-miR-1224-3p	CLIP-seq
MIRT2566599	hsa-miR-1252	CLIP-seq
MIRT2566600	hsa-miR-1261	CLIP-seq
MIRT2566601	hsa-miR-1264	CLIP-seq
MIRT2566602	hsa-miR-1293	CLIP-seq
MIRT2566603	hsa-miR-1297	CLIP-seq
MIRT2036921	hsa-miR-1301	CLIP-seq
MIRT2266988	hsa-miR-1324	CLIP-seq
MIRT1129536	hsa-miR-139-3p	CLIP-seq
MIRT2566604	hsa-miR-142-5p	CLIP-seq
MIRT2566605	hsa-miR-150	CLIP-seq
MIRT2566606	hsa-miR-155	CLIP-seq
MIRT2566607	hsa-miR-182	CLIP-seq
MIRT2566608	hsa-miR-1913	CLIP-seq
MIRT2566609	hsa-miR-1914	CLIP-seq
MIRT2566610	hsa-miR-208a	CLIP-seq
MIRT2566611	hsa-miR-208b	CLIP-seq
MIRT2566612	hsa-miR-2117	CLIP-seq
MIRT2566613	hsa-miR-2355-5p	CLIP-seq
MIRT2566614	hsa-miR-2467-3p	CLIP-seq
MIRT2566615	hsa-miR-2467-5p	CLIP-seq
MIRT2566616	hsa-miR-26a	CLIP-seq
MIRT2566617	hsa-miR-26b	CLIP-seq
MIRT2566618	hsa-miR-299-5p	CLIP-seq
MIRT1129538	hsa-miR-300	CLIP-seq
MIRT2566619	hsa-miR-3064-3p	CLIP-seq
MIRT2566620	hsa-miR-3121-5p	CLIP-seq
MIRT2566621	hsa-miR-3148	CLIP-seq
MIRT2566622	hsa-miR-3149	CLIP-seq
MIRT2566623	hsa-miR-3156-3p	CLIP-seq
MIRT1129541	hsa-miR-3176	CLIP-seq
MIRT1129542	hsa-miR-3187-3p	CLIP-seq
MIRT2566624	hsa-miR-3188	CLIP-seq
MIRT2566625	hsa-miR-324-3p	CLIP-seq
MIRT2566626	hsa-miR-338-5p	CLIP-seq
MIRT2566627	hsa-miR-361-3p	CLIP-seq
MIRT2267002	hsa-miR-3617	CLIP-seq
MIRT2566628	hsa-miR-362-5p	CLIP-seq
MIRT2566629	hsa-miR-3647-3p	CLIP-seq
MIRT2566630	hsa-miR-3653	CLIP-seq
MIRT2566631	hsa-miR-3658	CLIP-seq
MIRT1129546	hsa-miR-3663-5p	CLIP-seq
MIRT2566632	hsa-miR-3667-5p	CLIP-seq
MIRT2566633	hsa-miR-3682-5p	CLIP-seq
MIRT2566634	hsa-miR-374a	CLIP-seq
MIRT2566635	hsa-miR-374b	CLIP-seq
MIRT2566636	hsa-miR-375	CLIP-seq
MIRT1129548	hsa-miR-381	CLIP-seq
MIRT1129549	hsa-miR-3922-3p	CLIP-seq
MIRT2566637	hsa-miR-3943	CLIP-seq
MIRT2566638	hsa-miR-3975	CLIP-seq
MIRT2566639	hsa-miR-409-3p	CLIP-seq
MIRT2566640	hsa-miR-4273	CLIP-seq
MIRT2566641	hsa-miR-4282	CLIP-seq
MIRT2566642	hsa-miR-4297	CLIP-seq
MIRT2566643	hsa-miR-4300	CLIP-seq
MIRT2566644	hsa-miR-4301	CLIP-seq
MIRT2566645	hsa-miR-4316	CLIP-seq
MIRT2566646	hsa-miR-4422	CLIP-seq
MIRT2566647	hsa-miR-4465	CLIP-seq
MIRT2566648	hsa-miR-4468	CLIP-seq
MIRT2566649	hsa-miR-4470	CLIP-seq
MIRT2566650	hsa-miR-4477a	CLIP-seq
MIRT2566651	hsa-miR-4480	CLIP-seq
MIRT2566652	hsa-miR-4481	CLIP-seq
MIRT2566653	hsa-miR-4483	CLIP-seq
MIRT2566654	hsa-miR-4511	CLIP-seq
MIRT2566655	hsa-miR-452	CLIP-seq
MIRT1129563	hsa-miR-4528	CLIP-seq
MIRT1129564	hsa-miR-4529-5p	CLIP-seq
MIRT2566656	hsa-miR-4533	CLIP-seq
MIRT2267018	hsa-miR-4633-3p	CLIP-seq
MIRT2566657	hsa-miR-4633-5p	CLIP-seq
MIRT2566658	hsa-miR-4654	CLIP-seq
MIRT2566659	hsa-miR-4658	CLIP-seq
MIRT2036924	hsa-miR-4659a-3p	CLIP-seq
MIRT2036925	hsa-miR-4659b-3p	CLIP-seq
MIRT2036926	hsa-miR-4660	CLIP-seq
MIRT1129567	hsa-miR-4666-3p	CLIP-seq
MIRT2566660	hsa-miR-4668-3p	CLIP-seq
MIRT2566661	hsa-miR-4668-5p	CLIP-seq
MIRT2566662	hsa-miR-4676-3p	CLIP-seq
MIRT2566663	hsa-miR-4677-5p	CLIP-seq
MIRT2566664	hsa-miR-4681	CLIP-seq
MIRT2566665	hsa-miR-4693-5p	CLIP-seq
MIRT1129570	hsa-miR-4698	CLIP-seq
MIRT2566666	hsa-miR-4700-3p	CLIP-seq
MIRT2566667	hsa-miR-4710	CLIP-seq
MIRT2267022	hsa-miR-4711-5p	CLIP-seq
MIRT2566668	hsa-miR-4713-5p	CLIP-seq
MIRT2566669	hsa-miR-4715-3p	CLIP-seq
MIRT2566670	hsa-miR-4729	CLIP-seq
MIRT2566671	hsa-miR-4745-5p	CLIP-seq
MIRT2566672	hsa-miR-4747-5p	CLIP-seq
MIRT2566673	hsa-miR-4758-5p	CLIP-seq
MIRT2566674	hsa-miR-4765	CLIP-seq
MIRT2566675	hsa-miR-4766-3p	CLIP-seq
MIRT2566676	hsa-miR-4769-5p	CLIP-seq
MIRT2566677	hsa-miR-4778-3p	CLIP-seq
MIRT2566678	hsa-miR-4786-3p	CLIP-seq
MIRT1129574	hsa-miR-4789-5p	CLIP-seq
MIRT1129575	hsa-miR-4802-3p	CLIP-seq
MIRT2566679	hsa-miR-483-5p	CLIP-seq
MIRT2566680	hsa-miR-485-5p	CLIP-seq
MIRT2566681	hsa-miR-494	CLIP-seq
MIRT2566682	hsa-miR-499-5p	CLIP-seq
MIRT2566683	hsa-miR-500b	CLIP-seq
MIRT1129576	hsa-miR-501-5p	CLIP-seq
MIRT2036928	hsa-miR-5047	CLIP-seq
MIRT2566684	hsa-miR-5096	CLIP-seq
MIRT2566685	hsa-miR-513a-3p	CLIP-seq
MIRT2566686	hsa-miR-513b	CLIP-seq
MIRT2566687	hsa-miR-513c	CLIP-seq
MIRT2566688	hsa-miR-514b-5p	CLIP-seq
MIRT2566689	hsa-miR-515-5p	CLIP-seq
MIRT2566690	hsa-miR-520d-5p	CLIP-seq
MIRT2566691	hsa-miR-524-5p	CLIP-seq
MIRT2566692	hsa-miR-532-3p	CLIP-seq
MIRT2036929	hsa-miR-548a-5p	CLIP-seq
MIRT2036930	hsa-miR-548ab	CLIP-seq
MIRT2036931	hsa-miR-548ak	CLIP-seq
MIRT2566693	hsa-miR-548b-3p	CLIP-seq
MIRT2036932	hsa-miR-548b-5p	CLIP-seq
MIRT2036933	hsa-miR-548c-5p	CLIP-seq
MIRT2036934	hsa-miR-548d-5p	CLIP-seq
MIRT2036935	hsa-miR-548h	CLIP-seq
MIRT2036936	hsa-miR-548i	CLIP-seq
MIRT2036937	hsa-miR-548j	CLIP-seq
MIRT2566694	hsa-miR-548k	CLIP-seq
MIRT2566695	hsa-miR-548l	CLIP-seq
MIRT1129582	hsa-miR-548n	CLIP-seq
MIRT2566696	hsa-miR-548p	CLIP-seq
MIRT1129584	hsa-miR-548t	CLIP-seq
MIRT2036938	hsa-miR-548w	CLIP-seq
MIRT2036939	hsa-miR-548y	CLIP-seq
MIRT1129585	hsa-miR-550a	CLIP-seq
MIRT2566697	hsa-miR-556-3p	CLIP-seq
MIRT2036940	hsa-miR-559	CLIP-seq
MIRT2566698	hsa-miR-579	CLIP-seq
MIRT2566699	hsa-miR-586	CLIP-seq
MIRT2566700	hsa-miR-587	CLIP-seq
MIRT2566701	hsa-miR-591	CLIP-seq
MIRT2566702	hsa-miR-604	CLIP-seq
MIRT1129598	hsa-miR-605	CLIP-seq
MIRT2566703	hsa-miR-616	CLIP-seq
MIRT2566704	hsa-miR-622	CLIP-seq
MIRT2267029	hsa-miR-641	CLIP-seq
MIRT2566705	hsa-miR-647	CLIP-seq
MIRT2566706	hsa-miR-664	CLIP-seq
MIRT2566707	hsa-miR-671-5p	CLIP-seq
MIRT1129595	hsa-miR-759	CLIP-seq
MIRT2566708	hsa-miR-889	CLIP-seq
MIRT2566709	hsa-miR-9	CLIP-seq
MIRT2566710	hsa-miR-920	CLIP-seq
MIRT2267002	hsa-miR-3617	CLIP-seq
MIRT2267029	hsa-miR-641	CLIP-seq
MIRT2267002	hsa-miR-3617	CLIP-seq
MIRT2267018	hsa-miR-4633-3p	CLIP-seq
MIRT2036929	hsa-miR-548a-5p	CLIP-seq
MIRT2036930	hsa-miR-548ab	CLIP-seq
MIRT2036931	hsa-miR-548ak	CLIP-seq
MIRT2036932	hsa-miR-548b-5p	CLIP-seq
MIRT2036933	hsa-miR-548c-5p	CLIP-seq
MIRT2036934	hsa-miR-548d-5p	CLIP-seq
MIRT2036935	hsa-miR-548h	CLIP-seq
MIRT2036936	hsa-miR-548i	CLIP-seq
MIRT2036937	hsa-miR-548j	CLIP-seq
MIRT2036938	hsa-miR-548w	CLIP-seq
MIRT2036939	hsa-miR-548y	CLIP-seq
MIRT2036940	hsa-miR-559	CLIP-seq
MIRT2267029	hsa-miR-641	CLIP-seq
MIRT2267002	hsa-miR-3617	CLIP-seq
MIRT2267029	hsa-miR-641	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IBA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001953	Process	Negative regulation of cell-matrix adhesion	NAS	25490267
GO:0004111	Function	Creatine kinase activity	IDA	23207904
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9890973
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	12387898, 14966141, 25852190, 29961565, 32707033, 33961781
GO:0005524	Function	ATP binding	IDA	9890973
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	26437443
GO:0005737	Component	Cytoplasm	IDA	14966141
GO:0005737	Component	Cytoplasm	IEA
GO:0005925	Component	Focal adhesion	IDA	25490267
GO:0006468	Process	Protein phosphorylation	IDA	9890973
GO:0008017	Function	Microtubule binding	IDA	25490267
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IDA	26437443
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	24163766
GO:0032014	Process	Positive regulation of ARF protein signal transduction	ISS	25490267
GO:0035329	Process	Hippo signaling	IDA	35429439
GO:0035332	Process	Positive regulation of hippo signaling	IDA	26437443
GO:0035556	Process	Intracellular signal transduction	IDA	9890973
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21196414
GO:0043408	Process	Regulation of MAPK cascade	IBA
GO:0046328	Process	Regulation of JNK cascade	IDA	14966141
GO:0046328	Process	Regulation of JNK cascade	IEA
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0051549	Process	Positive regulation of keratinocyte migration	ISS	25490267
GO:0051894	Process	Positive regulation of focal adhesion assembly	ISS	25490267
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0120183	Process	Positive regulation of focal adhesion disassembly	ISS	25490267
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA

MIM	HGNC	e!Ensembl
604666	6866	ENSG00000071054

O95819

Protein name

Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)

Protein function

Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a piv

PDB

4OBO , 4OBP , 4OBQ , 4RVT , 4U3Y , 4U3Z , 4U40 , 4U41 , 4U42 , 4U43 , 4U44 , 4U45 , 4ZK5 , 4ZP5 , 5DI1 , 5J95 , 5W5Q , 8V5I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	25 → 289	Protein kinase domain	Domain
PF00780	CNH	930 → 1210	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}.

Sequence

MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP
PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS
ESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIE
PRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRL
ENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDD
VEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT
QSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGS
VVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYP
LINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDL
EGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEE
GQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDE
GVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRA
QRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW

Sequence length

1239

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway		Oxidative Stress Induced Senescence

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cerebral arteriovenous malformation	Likely pathogenic	rs781410462	RCV000656330
Imperforate anus	Likely pathogenic	rs2468868556	RCV002468742
Renal dysplasia	Likely pathogenic	rs2468868556	RCV002468742

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs62153660	RCV005915626
Cervical cancer	Benign	rs62153660	RCV005915628
Cholangiocarcinoma	Benign	rs62153660	RCV005915630
Malignant tumor of esophagus	Benign	rs62153660	RCV005915627
Sarcoma	Benign	rs62153660, rs79626224	RCV005915629 RCV005921447
Uterine corpus endometrial carcinoma	Benign	rs62153660	RCV005915631

Show/Hide Text Mining Associations (52)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Autism Spectrum Disorder	Associate	36469137
Azoospermia	Inhibit	36497065
Bantu siderosis	Associate	18840782
Breast Neoplasms	Associate	25148458, 37312710
Carcinogenesis	Associate	26269113
Carcinoma Hepatocellular	Associate	20857524
Cardiomyopathies	Associate	32694738
Cardiotoxicity	Associate	32694738
Colorectal Neoplasms	Associate	26499327, 29138007, 30361904
Developmental Disabilities	Associate	36469137
Diabetes Mellitus	Associate	23094072, 27174326
Diabetes Mellitus Type 2	Associate	23094072, 26918832, 27174326, 32993798
Fatty Liver	Associate	35679904
Fatty Liver Alcoholic	Associate	35679904
Fibrosis	Associate	35679904
Focal Cortical Dysplasia	Associate	34301297
Focal cortical dysplasia of Taylor	Associate	34301297
Fractures Bone	Associate	25148458
Glioblastoma	Associate	31570734
Glioma	Associate	31570734
Glucose Intolerance	Associate	23094072
Heart Diseases	Associate	32694738
Infertility Male	Inhibit	36497065
Inflammation	Associate	23094072, 24244164
Insulin Resistance	Associate	17227768, 23094072, 27174326
Insulinoma	Associate	23094072
Lead Poisoning Nervous System	Associate	35679904
Leukemia Lymphocytic Chronic B Cell	Associate	18945750
Leukemia Myeloid Acute	Associate	31522654
Muscle Neoplasms	Associate	32694738
Neoplasm Metastasis	Associate	28591712, 29138007, 29461619, 34112843
Neoplasms	Associate	16537454, 25337707, 32694738, 32810161, 34112843, 35296518, 36292671, 37312710
Non alcoholic Fatty Liver Disease	Associate	35679904
Nonsyndromic Holoprosencephaly	Associate	36469137
Obesity	Stimulate	19351711
Obesity	Associate	26918832
Osteoporosis	Associate	25148458
Ovarian Neoplasms	Associate	36922678
Pancreatic Neoplasms	Associate	26269113, 30710069
Peritonitis	Associate	36922678
Prediabetic State	Associate	23094072
Prostate Cancer Hereditary 7	Associate	24708576
Prostatic Hyperplasia	Associate	24474452
Prostatic Neoplasms	Associate	31241916, 34112843, 34475205
Sarcoma Kaposi	Associate	24244164
Sick Sinus Syndrome	Associate	36171622
Stomach Neoplasms	Stimulate	26549737
Stomach Neoplasms	Associate	36171622, 36292671
Thyroid Cancer Papillary	Associate	28855631
Thyroid Neoplasms	Stimulate	28855631
Uterine Cervical Neoplasms	Associate	29461619
Wilms Tumor	Associate	32214060

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)