GSTO1 (glutathione S-transferase omega 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9446
Gene name Gene Name - the full gene name approved by the HGNC.
Glutathione S-transferase omega 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSTO1
Synonyms (NCBI Gene) Gene synonyms aliases
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded prot
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT023892 hsa-miR-1-3p Proteomics 18668040
MIRT048048 hsa-miR-197-3p CLASH 23622248
MIRT2007347 hsa-miR-1252 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(30)
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 11511179
GO:0004364 Function Glutathione transferase activity IEA
GO:0005515 Function Protein binding IPI 25277244
GO:0005737 Component Cytoplasm IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605482 13312 ENSG00000148834
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P78417
Protein name Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glut
Protein function Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic a
PDB 1EEM , 3LFL , 3VLN , 4IS0 , 4YQM , 4YQU , 4YQV , 5UEH , 5V3Q , 5YVN , 5YVO , 6MHB , 6MHC , 6MHD , 6PNM , 6PNN , 6PNO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13417 GST_N_3 26 → 101 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 108 → 219 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269|PubMed:10783391}.
Sequence
Sequence length 241
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis 		  Methylation
Glutathione conjugation
Vitamin C (ascorbate) metabolism
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Uterine Fibroids Uterine fibroids N/A N/A GWAS
Show/Hide Text Mining Associations (37)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 24417908
Alzheimer Disease Associate 15040808, 15985314
Breast Neoplasms Associate 23888047, 30873742
Carcinoma Hepatocellular Stimulate 27221910
Carcinoma Non Small Cell Lung Associate 28425245, 33236161
Carcinoma Renal Cell Associate 30224590
Carcinoma Transitional Cell Associate 28288548
Cardiomyopathy Hypertrophic Associate 31243064
Cognition Disorders Associate 27259244
Colorectal Neoplasms Associate 26046795, 27703239, 36129143