MED26 (mediator complex subunit 26)

Gene

• Entrez ID: 9441
• Gene name: Mediator complex subunit 26
• Gene symbol: MED26
• Synonyms (NCBI Gene): CRSP7, CRSP70
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. T

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044629	hsa-miR-320a	CLASH	23622248
MIRT564305	hsa-miR-9500	PAR-CLIP	20371350
MIRT564304	hsa-miR-4719	PAR-CLIP	20371350
MIRT564303	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT564302	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT564301	hsa-miR-4419a	PAR-CLIP	20371350
MIRT564300	hsa-miR-4510	PAR-CLIP	20371350
MIRT564299	hsa-miR-6127	PAR-CLIP	20371350
MIRT564298	hsa-miR-6129	PAR-CLIP	20371350
MIRT564297	hsa-miR-6130	PAR-CLIP	20371350
MIRT564296	hsa-miR-6133	PAR-CLIP	20371350
MIRT564294	hsa-miR-6077	PAR-CLIP	20371350
MIRT564295	hsa-miR-2052	PAR-CLIP	20371350
MIRT564293	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT564292	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT564291	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT564290	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT564289	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT564288	hsa-miR-8055	PAR-CLIP	20371350
MIRT564305	hsa-miR-9500	PAR-CLIP	20371350
MIRT564304	hsa-miR-4719	PAR-CLIP	20371350
MIRT564303	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT564302	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT564301	hsa-miR-4419a	PAR-CLIP	20371350
MIRT564300	hsa-miR-4510	PAR-CLIP	20371350
MIRT564299	hsa-miR-6127	PAR-CLIP	20371350
MIRT564298	hsa-miR-6129	PAR-CLIP	20371350
MIRT564297	hsa-miR-6130	PAR-CLIP	20371350
MIRT564296	hsa-miR-6133	PAR-CLIP	20371350
MIRT564294	hsa-miR-6077	PAR-CLIP	20371350
MIRT564295	hsa-miR-2052	PAR-CLIP	20371350
MIRT564293	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT564292	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT564291	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT564290	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT564289	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT564288	hsa-miR-8055	PAR-CLIP	20371350
MIRT1141453	hsa-miR-103a	CLIP-seq
MIRT1141454	hsa-miR-107	CLIP-seq
MIRT1141455	hsa-miR-1183	CLIP-seq
MIRT1141456	hsa-miR-1200	CLIP-seq
MIRT1141457	hsa-miR-1237	CLIP-seq
MIRT1141458	hsa-miR-124	CLIP-seq
MIRT1141459	hsa-miR-129-5p	CLIP-seq
MIRT1141460	hsa-miR-1301	CLIP-seq
MIRT1141461	hsa-miR-1304	CLIP-seq
MIRT1141462	hsa-miR-146a	CLIP-seq
MIRT1141463	hsa-miR-146b-5p	CLIP-seq
MIRT1141464	hsa-miR-15a	CLIP-seq
MIRT1141465	hsa-miR-15b	CLIP-seq
MIRT1141466	hsa-miR-16	CLIP-seq
MIRT1141467	hsa-miR-181a	CLIP-seq
MIRT1141468	hsa-miR-181b	CLIP-seq
MIRT1141469	hsa-miR-181c	CLIP-seq
MIRT1141470	hsa-miR-181d	CLIP-seq
MIRT1141471	hsa-miR-186	CLIP-seq
MIRT1141472	hsa-miR-195	CLIP-seq
MIRT1141473	hsa-miR-219-2-3p	CLIP-seq
MIRT1141474	hsa-miR-29a	CLIP-seq
MIRT1141475	hsa-miR-29b	CLIP-seq
MIRT1141476	hsa-miR-29c	CLIP-seq
MIRT1141477	hsa-miR-3125	CLIP-seq
MIRT1141478	hsa-miR-3133	CLIP-seq
MIRT1141479	hsa-miR-3134	CLIP-seq
MIRT1141480	hsa-miR-3692	CLIP-seq
MIRT1141481	hsa-miR-3714	CLIP-seq
MIRT1141482	hsa-miR-3910	CLIP-seq
MIRT1141483	hsa-miR-3916	CLIP-seq
MIRT1141484	hsa-miR-424	CLIP-seq
MIRT1141485	hsa-miR-425	CLIP-seq
MIRT1141486	hsa-miR-4251	CLIP-seq
MIRT1141487	hsa-miR-4262	CLIP-seq
MIRT1141488	hsa-miR-4310	CLIP-seq
MIRT1141489	hsa-miR-4324	CLIP-seq
MIRT1141490	hsa-miR-4448	CLIP-seq
MIRT1141491	hsa-miR-4470	CLIP-seq
MIRT1141492	hsa-miR-4509	CLIP-seq
MIRT1141493	hsa-miR-450b-5p	CLIP-seq
MIRT1141494	hsa-miR-4520a-5p	CLIP-seq
MIRT1141495	hsa-miR-4520b-5p	CLIP-seq
MIRT1141496	hsa-miR-4524	CLIP-seq
MIRT1141497	hsa-miR-4534	CLIP-seq
MIRT1141498	hsa-miR-4696	CLIP-seq
MIRT1141499	hsa-miR-4729	CLIP-seq
MIRT1141500	hsa-miR-4744	CLIP-seq
MIRT1141501	hsa-miR-4773	CLIP-seq
MIRT1141502	hsa-miR-4790-3p	CLIP-seq
MIRT1141503	hsa-miR-497	CLIP-seq
MIRT1141504	hsa-miR-503	CLIP-seq
MIRT1141505	hsa-miR-5047	CLIP-seq
MIRT1141506	hsa-miR-506	CLIP-seq
MIRT1141507	hsa-miR-507	CLIP-seq
MIRT1141508	hsa-miR-513a-3p	CLIP-seq
MIRT1141509	hsa-miR-513b	CLIP-seq
MIRT1141510	hsa-miR-518a-5p	CLIP-seq
MIRT1141511	hsa-miR-522	CLIP-seq
MIRT1141512	hsa-miR-527	CLIP-seq
MIRT1141513	hsa-miR-539	CLIP-seq
MIRT1141514	hsa-miR-544b	CLIP-seq
MIRT1141515	hsa-miR-548a-3p	CLIP-seq
MIRT1141516	hsa-miR-548aa	CLIP-seq
MIRT1141517	hsa-miR-548ac	CLIP-seq
MIRT1141518	hsa-miR-548ae	CLIP-seq
MIRT1141519	hsa-miR-548aj	CLIP-seq
MIRT1141520	hsa-miR-548am	CLIP-seq
MIRT1141521	hsa-miR-548d-3p	CLIP-seq
MIRT1141522	hsa-miR-548e	CLIP-seq
MIRT1141523	hsa-miR-548f	CLIP-seq
MIRT1141524	hsa-miR-548g	CLIP-seq
MIRT1141525	hsa-miR-548x	CLIP-seq
MIRT1141526	hsa-miR-548z	CLIP-seq
MIRT1141527	hsa-miR-557	CLIP-seq
MIRT1141528	hsa-miR-582-3p	CLIP-seq
MIRT1141529	hsa-miR-589	CLIP-seq
MIRT1141530	hsa-miR-646	CLIP-seq
MIRT1141531	hsa-miR-7	CLIP-seq
MIRT1141480	hsa-miR-3692	CLIP-seq
MIRT1141499	hsa-miR-4729	CLIP-seq
MIRT2040132	hsa-miR-1207-3p	CLIP-seq
MIRT2040133	hsa-miR-1224-3p	CLIP-seq
MIRT1141457	hsa-miR-1237	CLIP-seq
MIRT2040134	hsa-miR-1243	CLIP-seq
MIRT2040135	hsa-miR-1248	CLIP-seq
MIRT1141459	hsa-miR-129-5p	CLIP-seq
MIRT2040136	hsa-miR-1827	CLIP-seq
MIRT2040137	hsa-miR-193a-3p	CLIP-seq
MIRT2040138	hsa-miR-193b	CLIP-seq
MIRT2040139	hsa-miR-2276	CLIP-seq
MIRT2040140	hsa-miR-296-5p	CLIP-seq
MIRT2040141	hsa-miR-3128	CLIP-seq
MIRT2040142	hsa-miR-3186-3p	CLIP-seq
MIRT2040143	hsa-miR-3612	CLIP-seq
MIRT2040144	hsa-miR-3619-3p	CLIP-seq
MIRT2040145	hsa-miR-3654	CLIP-seq
MIRT2040146	hsa-miR-3667-3p	CLIP-seq
MIRT2040147	hsa-miR-3680	CLIP-seq
MIRT2040148	hsa-miR-3976	CLIP-seq
MIRT2040149	hsa-miR-4436b-5p	CLIP-seq
MIRT1141493	hsa-miR-450b-5p	CLIP-seq
MIRT2040150	hsa-miR-4539	CLIP-seq
MIRT2040151	hsa-miR-4652-3p	CLIP-seq
MIRT2040152	hsa-miR-4680-5p	CLIP-seq
MIRT2040153	hsa-miR-4695-5p	CLIP-seq
MIRT2040154	hsa-miR-4707-3p	CLIP-seq
MIRT2040155	hsa-miR-4707-5p	CLIP-seq
MIRT2040156	hsa-miR-4720-5p	CLIP-seq
MIRT2040157	hsa-miR-4763-5p	CLIP-seq
MIRT2040158	hsa-miR-4772-3p	CLIP-seq
MIRT2040159	hsa-miR-4776-5p	CLIP-seq
MIRT2040160	hsa-miR-4778-3p	CLIP-seq
MIRT2040161	hsa-miR-4799-3p	CLIP-seq
MIRT1141507	hsa-miR-507	CLIP-seq
MIRT2040162	hsa-miR-544	CLIP-seq
MIRT2040163	hsa-miR-548p	CLIP-seq
MIRT1141527	hsa-miR-557	CLIP-seq
MIRT2040164	hsa-miR-650	CLIP-seq
MIRT2040165	hsa-miR-941	CLIP-seq
MIRT2269987	hsa-miR-101	CLIP-seq
MIRT1141453	hsa-miR-103a	CLIP-seq
MIRT1141454	hsa-miR-107	CLIP-seq
MIRT1141455	hsa-miR-1183	CLIP-seq
MIRT1141456	hsa-miR-1200	CLIP-seq
MIRT1141457	hsa-miR-1237	CLIP-seq
MIRT1141459	hsa-miR-129-5p	CLIP-seq
MIRT1141461	hsa-miR-1304	CLIP-seq
MIRT2269988	hsa-miR-141	CLIP-seq
MIRT1141462	hsa-miR-146a	CLIP-seq
MIRT1141463	hsa-miR-146b-5p	CLIP-seq
MIRT1141464	hsa-miR-15a	CLIP-seq
MIRT1141465	hsa-miR-15b	CLIP-seq
MIRT1141466	hsa-miR-16	CLIP-seq
MIRT1141467	hsa-miR-181a	CLIP-seq
MIRT1141468	hsa-miR-181b	CLIP-seq
MIRT1141469	hsa-miR-181c	CLIP-seq
MIRT1141470	hsa-miR-181d	CLIP-seq
MIRT2040137	hsa-miR-193a-3p	CLIP-seq
MIRT2040138	hsa-miR-193b	CLIP-seq
MIRT1141472	hsa-miR-195	CLIP-seq
MIRT2269989	hsa-miR-200a	CLIP-seq
MIRT2269990	hsa-miR-3120-3p	CLIP-seq
MIRT2269991	hsa-miR-3176	CLIP-seq
MIRT2269992	hsa-miR-3922-3p	CLIP-seq
MIRT1141484	hsa-miR-424	CLIP-seq
MIRT1141485	hsa-miR-425	CLIP-seq
MIRT1141486	hsa-miR-4251	CLIP-seq
MIRT1141487	hsa-miR-4262	CLIP-seq
MIRT2269993	hsa-miR-4287	CLIP-seq
MIRT1141488	hsa-miR-4310	CLIP-seq
MIRT1141489	hsa-miR-4324	CLIP-seq
MIRT1141490	hsa-miR-4448	CLIP-seq
MIRT1141493	hsa-miR-450b-5p	CLIP-seq
MIRT1141494	hsa-miR-4520a-5p	CLIP-seq
MIRT1141495	hsa-miR-4520b-5p	CLIP-seq
MIRT2269994	hsa-miR-4685-3p	CLIP-seq
MIRT1141503	hsa-miR-497	CLIP-seq
MIRT1141507	hsa-miR-507	CLIP-seq
MIRT1141509	hsa-miR-513b	CLIP-seq
MIRT1141510	hsa-miR-518a-5p	CLIP-seq
MIRT1141512	hsa-miR-527	CLIP-seq
MIRT1141514	hsa-miR-544b	CLIP-seq
MIRT1141516	hsa-miR-548aa	CLIP-seq
MIRT2040163	hsa-miR-548p	CLIP-seq
MIRT1141527	hsa-miR-557	CLIP-seq
MIRT1141529	hsa-miR-589	CLIP-seq
MIRT2390790	hsa-miR-3132	CLIP-seq
MIRT2390791	hsa-miR-3652	CLIP-seq
MIRT2390792	hsa-miR-4430	CLIP-seq
MIRT2390793	hsa-miR-4505	CLIP-seq
MIRT2269987	hsa-miR-101	CLIP-seq
MIRT1141458	hsa-miR-124	CLIP-seq
MIRT2569070	hsa-miR-2113	CLIP-seq
MIRT1141474	hsa-miR-29a	CLIP-seq
MIRT1141475	hsa-miR-29b	CLIP-seq
MIRT1141476	hsa-miR-29c	CLIP-seq
MIRT2269990	hsa-miR-3120-3p	CLIP-seq
MIRT2569071	hsa-miR-3679-3p	CLIP-seq
MIRT1141481	hsa-miR-3714	CLIP-seq
MIRT1141482	hsa-miR-3910	CLIP-seq
MIRT1141491	hsa-miR-4470	CLIP-seq
MIRT1141492	hsa-miR-4509	CLIP-seq
MIRT1141500	hsa-miR-4744	CLIP-seq
MIRT2569072	hsa-miR-4758-3p	CLIP-seq
MIRT1141506	hsa-miR-506	CLIP-seq
MIRT1141516	hsa-miR-548aa	CLIP-seq
MIRT2569073	hsa-miR-599	CLIP-seq
MIRT2269987	hsa-miR-101	CLIP-seq
MIRT2269990	hsa-miR-3120-3p	CLIP-seq
MIRT2569071	hsa-miR-3679-3p	CLIP-seq
MIRT2569072	hsa-miR-4758-3p	CLIP-seq
MIRT1141516	hsa-miR-548aa	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003712	Function	Transcription coregulator activity	IDA	15989967
GO:0003713	Function	Transcription coactivator activity	TAS	9989412
GO:0005515	Function	Protein binding	IPI	15175163, 20111005, 21729782, 24882805, 24981860, 25281560, 28514442, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	24882805
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	15989967
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9989412
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	TAS	9989412
GO:0010628	Process	Positive regulation of gene expression	IBA
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IDA	15989967
GO:0016592	Component	Mediator complex	IEA
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	11559591
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	NAS	11559591
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	NAS	11559591
GO:0070847	Component	Core mediator complex	IBA
GO:0070847	Component	Core mediator complex	IPI	24882805

Other IDs

• MIM: 605043
• HGNC: 2376
• e!Ensembl: ENSG00000105085

Protein

• UniProt ID: O95402
• Protein name: Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactiv
• Protein function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
• PDB: 5ODD, 6ZV3, 7EMF, 7ENA, 7ENC, 7ENJ, 8GXQ, 8GXS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08711	Med26	33 → 84	TFIIS helical bundle-like domain	Domain
  PF15694	Med26_M	177 → 417	Mediator complex subunit 26 middle domain	Domain
  PF15693	Med26_C	419 → 598	Mediator complex subunit 26 C-terminal	Domain

• Sequence:

  MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDV
  RKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGP
  PRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPL
  PTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPG
  PCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSP
  SPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGL
  SPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRL
  KERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKEL
  SRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDL
  PGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
  

• Sequence length: 600

Pathways

Reactome:

PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation