TNFSF8 (TNF superfamily member 8)

Gene

• Entrez ID: 944
• Gene name: TNF superfamily member 8
• Gene symbol: TNFSF8
• Synonyms (NCBI Gene): CD153, CD30L, CD30LG, TNLG3A
• Chromosome: 9
• Chromosome location: 9q32-q33.1
• Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancie

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT650724	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT665107	hsa-miR-6510-5p	HITS-CLIP	23824327
MIRT650721	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT665106	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT650735	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT650734	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650732	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT650733	hsa-miR-4267	HITS-CLIP	23824327
MIRT650731	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT650730	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT650729	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT650728	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT650727	hsa-miR-5696	HITS-CLIP	23824327
MIRT650726	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT650725	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT650724	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT650723	hsa-miR-9500	HITS-CLIP	23824327
MIRT650721	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT650724	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT665107	hsa-miR-6510-5p	HITS-CLIP	23824327
MIRT650721	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT665106	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT650735	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT650734	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650732	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT650733	hsa-miR-4267	HITS-CLIP	23824327
MIRT650731	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT650730	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT650729	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT650728	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT650727	hsa-miR-5696	HITS-CLIP	23824327
MIRT650726	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT650725	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT650724	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT650723	hsa-miR-9500	HITS-CLIP	23824327
MIRT650721	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT1443570	hsa-miR-1228	CLIP-seq
MIRT1443571	hsa-miR-128	CLIP-seq
MIRT1443572	hsa-miR-1284	CLIP-seq
MIRT1443573	hsa-miR-140-3p	CLIP-seq
MIRT1443574	hsa-miR-30a	CLIP-seq
MIRT1443575	hsa-miR-30b	CLIP-seq
MIRT1443576	hsa-miR-30c	CLIP-seq
MIRT1443577	hsa-miR-30d	CLIP-seq
MIRT1443578	hsa-miR-30e	CLIP-seq
MIRT1443579	hsa-miR-3115	CLIP-seq
MIRT1443580	hsa-miR-629	CLIP-seq
MIRT2132742	hsa-miR-2053	CLIP-seq
MIRT2353820	hsa-miR-1243	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	8391931
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	TAS	8391931
GO:0006955	Process	Immune response	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007267	Process	Cell-cell signaling	TAS	8391931
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0042129	Process	Regulation of T cell proliferation	TAS	8391931
GO:0043374	Process	CD8-positive, alpha-beta T cell differentiation	IBA
GO:0043374	Process	CD8-positive, alpha-beta T cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA

Other IDs

• MIM: 603875
• HGNC: 11938
• e!Ensembl: ENSG00000106952

Protein

• UniProt ID: P32971
• Protein name: Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)
• Protein function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00229	TNF	113 → 230	TNF(Tumour Necrosis Factor) family	Domain

• Sequence:

  MDPGLQQALNGMAPPGDTAMHVPAGSVASHLGTTSRSYFYLTTATLALCLVFTVATIMVL
  VVQRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGI
  LHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESG
  MQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD

• Sequence length: 234

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

TNFs bind their physiological receptors