Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9435
Gene name	Carbohydrate sulfotransferase 2
Gene symbol	CHST2
Synonyms (NCBI Gene)	C6STGST-2GST2Gn6ST-1HEL-S-75glcNAc6ST-1
Chromosome	3
Chromosome location	3q24
Summary	This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]

Show/Hide all (74)

miRTarBase ID	miRNA	Experiments	Reference
MIRT704694	hsa-miR-595	HITS-CLIP	23313552
MIRT704693	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT704692	hsa-miR-888-5p	HITS-CLIP	23313552
MIRT704691	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT704690	hsa-miR-1323	HITS-CLIP	23313552
MIRT704689	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT704688	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT704687	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT704686	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT704685	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT704684	hsa-miR-345-5p	HITS-CLIP	23313552
MIRT704683	hsa-miR-2277-3p	HITS-CLIP	23313552
MIRT704682	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT704681	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT704680	hsa-miR-8070	HITS-CLIP	23313552
MIRT704679	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT704678	hsa-miR-6083	HITS-CLIP	23313552
MIRT704677	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT704694	hsa-miR-595	HITS-CLIP	23313552
MIRT704693	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT704692	hsa-miR-888-5p	HITS-CLIP	23313552
MIRT704691	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT704690	hsa-miR-1323	HITS-CLIP	23313552
MIRT704689	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT704688	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT704687	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT704686	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT704685	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT704684	hsa-miR-345-5p	HITS-CLIP	23313552
MIRT704683	hsa-miR-2277-3p	HITS-CLIP	23313552
MIRT704682	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT704681	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT704680	hsa-miR-8070	HITS-CLIP	23313552
MIRT704679	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT704678	hsa-miR-6083	HITS-CLIP	23313552
MIRT704677	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT892303	hsa-miR-1299	CLIP-seq
MIRT892304	hsa-miR-203	CLIP-seq
MIRT892305	hsa-miR-2113	CLIP-seq
MIRT892306	hsa-miR-30a	CLIP-seq
MIRT892307	hsa-miR-30b	CLIP-seq
MIRT892308	hsa-miR-30c	CLIP-seq
MIRT892309	hsa-miR-30d	CLIP-seq
MIRT892310	hsa-miR-30e	CLIP-seq
MIRT892311	hsa-miR-3127-3p	CLIP-seq
MIRT892312	hsa-miR-3143	CLIP-seq
MIRT892313	hsa-miR-3156-3p	CLIP-seq
MIRT892314	hsa-miR-3619-3p	CLIP-seq
MIRT892315	hsa-miR-378	CLIP-seq
MIRT892316	hsa-miR-378b	CLIP-seq
MIRT892317	hsa-miR-378c	CLIP-seq
MIRT892318	hsa-miR-378d	CLIP-seq
MIRT892319	hsa-miR-378e	CLIP-seq
MIRT892320	hsa-miR-378f	CLIP-seq
MIRT892321	hsa-miR-378h	CLIP-seq
MIRT892322	hsa-miR-378i	CLIP-seq
MIRT892323	hsa-miR-3940-5p	CLIP-seq
MIRT892324	hsa-miR-422a	CLIP-seq
MIRT892325	hsa-miR-4301	CLIP-seq
MIRT892326	hsa-miR-4326	CLIP-seq
MIRT892327	hsa-miR-4474-3p	CLIP-seq
MIRT892328	hsa-miR-4507	CLIP-seq
MIRT892329	hsa-miR-4638-3p	CLIP-seq
MIRT892330	hsa-miR-4687-3p	CLIP-seq
MIRT892331	hsa-miR-4776-5p	CLIP-seq
MIRT892332	hsa-miR-4782-5p	CLIP-seq
MIRT892333	hsa-miR-502-5p	CLIP-seq
MIRT892334	hsa-miR-516b	CLIP-seq
MIRT892335	hsa-miR-555	CLIP-seq
MIRT892336	hsa-miR-765	CLIP-seq
MIRT2503380	hsa-miR-548o	CLIP-seq
MIRT2503381	hsa-miR-888	CLIP-seq
MIRT2503380	hsa-miR-548o	CLIP-seq
MIRT2503381	hsa-miR-888	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	NAS	12855678
GO:0000139	Component	Golgi membrane	TAS
GO:0001517	Function	N-acetylglucosamine 6-O-sulfotransferase activity	IBA
GO:0001517	Function	N-acetylglucosamine 6-O-sulfotransferase activity	IDA	9722682, 11042394
GO:0001517	Function	N-acetylglucosamine 6-O-sulfotransferase activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005802	Component	Trans-Golgi network	IDA	12855678
GO:0005829	Component	Cytosol	IDA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006044	Process	N-acetylglucosamine metabolic process	IBA
GO:0006044	Process	N-acetylglucosamine metabolic process	IDA	9722682
GO:0006044	Process	N-acetylglucosamine metabolic process	IEA
GO:0006790	Process	Sulfur compound metabolic process	IBA
GO:0006790	Process	Sulfur compound metabolic process	IDA	9722682
GO:0006790	Process	Sulfur compound metabolic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	10049591
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008146	Function	Sulfotransferase activity	TAS	9722682
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018146	Process	Keratan sulfate proteoglycan biosynthetic process	TAS
GO:1903238	Process	Positive regulation of leukocyte tethering or rolling	IEA
GO:1903238	Process	Positive regulation of leukocyte tethering or rolling	ISS

MIM	HGNC	e!Ensembl
603798	1970	ENSG00000175040

Q9Y4C5

Protein name

Carbohydrate sulfotransferase 2 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2) (GST-2) (N-acetylglucosamine 6-O-sulfotransferase 1) (GlcNAc6ST-1) (Gn6ST-1)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans an

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	164 → 507	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:10049591, ECO:0000269|PubMed

Sequence

MSRSPQRALPPGALPRLLQAAPAAAPRALLPQWPRRPGRRWPASPLGMKVFRRKALVLCA
GYALLLVLTMLNLLDYKWHKEPLQQCNPDGPLGAAAGAAGGSWGRPGPPPAGPPRAHARL
DLRTPYRPPAAAVGAAPAAAAGMAGVAAPPGNGTRGTGGVGDKRQLVYVFTTWRSGSSFF
GELFNQNPEVFFLYEPVWHVWQKLYPGDAVSLQGAARDMLSALYRCDLSVFQLYSPAGSG
GRNLTTLGIFGAATNKVVCSSPLCPAYRKEVVGLVDDRVCKKCPPQRLARFEEECRKYRT
LVIKGVRVFDVAVLAPLLRDPALDLKVIHLVRDPRAVASSRIRSRHGLIRESLQVVRSRD
PRAHRMPFLEAAGHKLGAKKEGVGGPADYHALGAMEVICNSMAKTLQTALQPPDWLQGHY
LVVRYEDLVGDPVKTLRRVYDFVGLLVSPEMEQFALNMTSGSGSSSKPFVVSARNATQAA
NAWRTALTFQQIKQVEEFCYQPMAVLGYERVNSPEEVKDLSKTLLRKPRL

Sequence length

530

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - keratan sulfate		Keratan sulfate biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CIRRHOSIS OF LIVER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colitis Ulcerative	Associate	39596612	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Associate	26631031	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Hemorrhage	Associate	35114859	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	38019838	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	26631031	★★★★★ ★☆☆☆☆ Found in Text Mining only

CHST2 (carbohydrate sulfotransferase 2)