PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
94274
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 1 regulatory inhibitor subunit 14A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP1R14A
Synonyms (NCBI Gene) Gene synonyms aliases
CPI-17, CPI17, PPP1INL
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(30)
miRTarBase ID miRNA Experiments Reference
MIRT044653 hsa-miR-320a CLASH 23622248
MIRT485984 hsa-miR-6784-5p PAR-CLIP 23592263
MIRT485983 hsa-miR-1207-5p PAR-CLIP 23592263
MIRT485982 hsa-miR-4763-3p PAR-CLIP 23592263
MIRT485981 hsa-miR-4467 PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0004864 Function Protein phosphatase inhibitor activity IEA
GO:0004865 Function Protein serine/threonine phosphatase inhibitor activity IBA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
GO:0071466 Process Cellular response to xenobiotic stimulus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608153 14871 ENSG00000167641
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96A00
Protein name Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17)
Protein function Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05361 PP1_inhibitor 1 → 136 PKC-activated protein phosphatase-1 inhibitor Family
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. {ECO:0000269|PubMed:11467857}.
Sequence
Sequence length 147
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Vascular smooth muscle contraction   RHO GTPases activate PKNs
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer N/A N/A GWAS
Show/Hide Text Mining Associations (15)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Injuries Associate 35173190
Colorectal Neoplasms Associate 40001597
Diabetes Mellitus Associate 29955616
Esophageal Neoplasms Associate 19472401
Esophageal Squamous Cell Carcinoma Associate 19472401
Hereditary Breast and Ovarian Cancer Syndrome Associate 28115406
Inflammation Associate 23800065
Lymphoma Associate 24260260
Lymphoma B Cell Associate 24260260
Neoplasms Associate 23800065, 24260260, 31959204