Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9423
Gene name Gene Name - the full gene name approved by the HGNC.	Netrin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NTN1
Synonyms (NCBI Gene) Gene synonyms aliases	MRMV4, NET1, NTN1L
Disease Acronyms (UniProt) Disease acronyms from UniProt database	MRMV4
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019443	hsa-miR-148b-3p	Microarray	17612493
MIRT042477	hsa-miR-423-3p	CLASH	23622248
MIRT036113	hsa-miR-1296-5p	CLASH	23622248
MIRT715335	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT715334	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT715333	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT715332	hsa-miR-1913	HITS-CLIP	19536157
MIRT715331	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT715330	hsa-miR-4313	HITS-CLIP	19536157
MIRT715329	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT462818	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT462817	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT462816	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT462815	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT462814	hsa-miR-4779	PAR-CLIP	23592263
MIRT462813	hsa-miR-1321	PAR-CLIP	23592263
MIRT462811	hsa-miR-4739	PAR-CLIP	23592263
MIRT462812	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT462810	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT462809	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT462808	hsa-miR-4419a	PAR-CLIP	23592263
MIRT462807	hsa-miR-4510	PAR-CLIP	23592263
MIRT462806	hsa-miR-6127	PAR-CLIP	23592263
MIRT462805	hsa-miR-6129	PAR-CLIP	23592263
MIRT462804	hsa-miR-6130	PAR-CLIP	23592263
MIRT462803	hsa-miR-6133	PAR-CLIP	23592263
MIRT462802	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT462801	hsa-miR-765	PAR-CLIP	23592263
MIRT462800	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462798	hsa-miR-4271	PAR-CLIP	23592263
MIRT462799	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462797	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462796	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT715335	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT715334	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT715333	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT715332	hsa-miR-1913	HITS-CLIP	19536157
MIRT715331	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT715330	hsa-miR-4313	HITS-CLIP	19536157
MIRT715329	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT462818	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT462817	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT462816	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT462815	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT462814	hsa-miR-4779	PAR-CLIP	23592263
MIRT462813	hsa-miR-1321	PAR-CLIP	23592263
MIRT462811	hsa-miR-4739	PAR-CLIP	23592263
MIRT462812	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT462810	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT462809	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT462808	hsa-miR-4419a	PAR-CLIP	23592263
MIRT462807	hsa-miR-4510	PAR-CLIP	23592263
MIRT462806	hsa-miR-6127	PAR-CLIP	23592263
MIRT462805	hsa-miR-6129	PAR-CLIP	23592263
MIRT462804	hsa-miR-6130	PAR-CLIP	23592263
MIRT462803	hsa-miR-6133	PAR-CLIP	23592263
MIRT462802	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT462801	hsa-miR-765	PAR-CLIP	23592263
MIRT462800	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462798	hsa-miR-4271	PAR-CLIP	23592263
MIRT462799	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462797	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462796	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT1196084	hsa-miR-103a	CLIP-seq
MIRT1196085	hsa-miR-106a	CLIP-seq
MIRT1196086	hsa-miR-106b	CLIP-seq
MIRT1196087	hsa-miR-107	CLIP-seq
MIRT1196088	hsa-miR-1197	CLIP-seq
MIRT1196089	hsa-miR-1254	CLIP-seq
MIRT1196090	hsa-miR-1282	CLIP-seq
MIRT1196091	hsa-miR-1286	CLIP-seq
MIRT1196092	hsa-miR-1301	CLIP-seq
MIRT1196093	hsa-miR-1307	CLIP-seq
MIRT1196094	hsa-miR-1471	CLIP-seq
MIRT1196095	hsa-miR-17	CLIP-seq
MIRT1196096	hsa-miR-188-3p	CLIP-seq
MIRT1196097	hsa-miR-1915	CLIP-seq
MIRT1196098	hsa-miR-1972	CLIP-seq
MIRT1196099	hsa-miR-204	CLIP-seq
MIRT1196100	hsa-miR-20a	CLIP-seq
MIRT1196101	hsa-miR-20b	CLIP-seq
MIRT1196102	hsa-miR-211	CLIP-seq
MIRT1196103	hsa-miR-2114	CLIP-seq
MIRT1196104	hsa-miR-299-3p	CLIP-seq
MIRT1196105	hsa-miR-3064-5p	CLIP-seq
MIRT1196106	hsa-miR-3116	CLIP-seq
MIRT1196107	hsa-miR-3122	CLIP-seq
MIRT1196108	hsa-miR-3145-5p	CLIP-seq
MIRT1196109	hsa-miR-3166	CLIP-seq
MIRT1196110	hsa-miR-3184	CLIP-seq
MIRT1196111	hsa-miR-3189-3p	CLIP-seq
MIRT1196112	hsa-miR-3192	CLIP-seq
MIRT1196113	hsa-miR-339-5p	CLIP-seq
MIRT1196114	hsa-miR-3609	CLIP-seq
MIRT1196115	hsa-miR-3689a-3p	CLIP-seq
MIRT1196116	hsa-miR-3689c	CLIP-seq
MIRT1196117	hsa-miR-3691-3p	CLIP-seq
MIRT1196118	hsa-miR-3913-5p	CLIP-seq
MIRT1196119	hsa-miR-423-5p	CLIP-seq
MIRT1196120	hsa-miR-4278	CLIP-seq
MIRT1196121	hsa-miR-4297	CLIP-seq
MIRT1196122	hsa-miR-4300	CLIP-seq
MIRT1196123	hsa-miR-4436a	CLIP-seq
MIRT1196124	hsa-miR-4459	CLIP-seq
MIRT1196125	hsa-miR-4467	CLIP-seq
MIRT1196126	hsa-miR-4468	CLIP-seq
MIRT1196127	hsa-miR-4496	CLIP-seq
MIRT1196128	hsa-miR-450a	CLIP-seq
MIRT1196129	hsa-miR-4519	CLIP-seq
MIRT1196130	hsa-miR-4643	CLIP-seq
MIRT1196131	hsa-miR-4650-5p	CLIP-seq
MIRT1196132	hsa-miR-466	CLIP-seq
MIRT1196133	hsa-miR-4685-5p	CLIP-seq
MIRT1196134	hsa-miR-4688	CLIP-seq
MIRT1196135	hsa-miR-4695-5p	CLIP-seq
MIRT1196136	hsa-miR-4707-3p	CLIP-seq
MIRT1196137	hsa-miR-4716-3p	CLIP-seq
MIRT1196138	hsa-miR-4725-5p	CLIP-seq
MIRT1196139	hsa-miR-4728-5p	CLIP-seq
MIRT1196140	hsa-miR-4755-5p	CLIP-seq
MIRT1196141	hsa-miR-4771	CLIP-seq
MIRT1196142	hsa-miR-4780	CLIP-seq
MIRT1196143	hsa-miR-4789-3p	CLIP-seq
MIRT1196144	hsa-miR-4796-3p	CLIP-seq
MIRT1196145	hsa-miR-504	CLIP-seq
MIRT1196146	hsa-miR-5047	CLIP-seq
MIRT1196147	hsa-miR-515-3p	CLIP-seq
MIRT1196148	hsa-miR-519a	CLIP-seq
MIRT1196149	hsa-miR-519d	CLIP-seq
MIRT1196150	hsa-miR-519e	CLIP-seq
MIRT1196151	hsa-miR-548ah	CLIP-seq
MIRT1196152	hsa-miR-550a	CLIP-seq
MIRT1196153	hsa-miR-555	CLIP-seq
MIRT1196154	hsa-miR-603	CLIP-seq
MIRT1196155	hsa-miR-623	CLIP-seq
MIRT1196156	hsa-miR-635	CLIP-seq
MIRT1196157	hsa-miR-640	CLIP-seq
MIRT1196158	hsa-miR-661	CLIP-seq
MIRT1196159	hsa-miR-665	CLIP-seq
MIRT1196160	hsa-miR-892b	CLIP-seq
MIRT1196161	hsa-miR-920	CLIP-seq
MIRT1196162	hsa-miR-93	CLIP-seq
MIRT1196085	hsa-miR-106a	CLIP-seq
MIRT1196086	hsa-miR-106b	CLIP-seq
MIRT2056888	hsa-miR-1200	CLIP-seq
MIRT1196089	hsa-miR-1254	CLIP-seq
MIRT2056889	hsa-miR-1266	CLIP-seq
MIRT2056890	hsa-miR-1273e	CLIP-seq
MIRT2056891	hsa-miR-1294	CLIP-seq
MIRT1196093	hsa-miR-1307	CLIP-seq
MIRT2056892	hsa-miR-1587	CLIP-seq
MIRT2056893	hsa-miR-15a	CLIP-seq
MIRT2056894	hsa-miR-15b	CLIP-seq
MIRT2056895	hsa-miR-16	CLIP-seq
MIRT1196095	hsa-miR-17	CLIP-seq
MIRT2056896	hsa-miR-1827	CLIP-seq
MIRT2056897	hsa-miR-1909	CLIP-seq
MIRT2056898	hsa-miR-195	CLIP-seq
MIRT1196100	hsa-miR-20a	CLIP-seq
MIRT1196101	hsa-miR-20b	CLIP-seq
MIRT2056899	hsa-miR-2110	CLIP-seq
MIRT2056900	hsa-miR-214	CLIP-seq
MIRT2056901	hsa-miR-2277-3p	CLIP-seq
MIRT2056902	hsa-miR-296-5p	CLIP-seq
MIRT1196104	hsa-miR-299-3p	CLIP-seq
MIRT2056903	hsa-miR-3074-5p	CLIP-seq
MIRT1196106	hsa-miR-3116	CLIP-seq
MIRT2056904	hsa-miR-3124-3p	CLIP-seq
MIRT2056905	hsa-miR-3140-5p	CLIP-seq
MIRT2056906	hsa-miR-3153	CLIP-seq
MIRT1196110	hsa-miR-3184	CLIP-seq
MIRT1196111	hsa-miR-3189-3p	CLIP-seq
MIRT1196114	hsa-miR-3609	CLIP-seq
MIRT2056907	hsa-miR-3619-5p	CLIP-seq
MIRT2056908	hsa-miR-3665	CLIP-seq
MIRT2056909	hsa-miR-378g	CLIP-seq
MIRT2056910	hsa-miR-3907	CLIP-seq
MIRT1196119	hsa-miR-423-5p	CLIP-seq
MIRT2056911	hsa-miR-424	CLIP-seq
MIRT2056912	hsa-miR-4267	CLIP-seq
MIRT1196122	hsa-miR-4300	CLIP-seq
MIRT2056913	hsa-miR-4308	CLIP-seq
MIRT2056914	hsa-miR-4316	CLIP-seq
MIRT2056915	hsa-miR-4417	CLIP-seq
MIRT2056916	hsa-miR-4492	CLIP-seq
MIRT1196127	hsa-miR-4496	CLIP-seq
MIRT2056917	hsa-miR-4498	CLIP-seq
MIRT2056918	hsa-miR-4505	CLIP-seq
MIRT2056919	hsa-miR-4514	CLIP-seq
MIRT2056920	hsa-miR-4518	CLIP-seq
MIRT1196131	hsa-miR-4650-5p	CLIP-seq
MIRT2056921	hsa-miR-4652-5p	CLIP-seq
MIRT2056922	hsa-miR-4655-5p	CLIP-seq
MIRT2056923	hsa-miR-4656	CLIP-seq
MIRT2056924	hsa-miR-4660	CLIP-seq
MIRT2056925	hsa-miR-4675	CLIP-seq
MIRT2056926	hsa-miR-4692	CLIP-seq
MIRT2056927	hsa-miR-4694-3p	CLIP-seq
MIRT1196136	hsa-miR-4707-3p	CLIP-seq
MIRT2056928	hsa-miR-4741	CLIP-seq
MIRT2056929	hsa-miR-4747-5p	CLIP-seq
MIRT2056930	hsa-miR-4755-3p	CLIP-seq
MIRT2056931	hsa-miR-4786-3p	CLIP-seq
MIRT1196144	hsa-miR-4796-3p	CLIP-seq
MIRT2056932	hsa-miR-497	CLIP-seq
MIRT1196147	hsa-miR-515-3p	CLIP-seq
MIRT1196149	hsa-miR-519d	CLIP-seq
MIRT1196150	hsa-miR-519e	CLIP-seq
MIRT2056933	hsa-miR-522	CLIP-seq
MIRT2056934	hsa-miR-541	CLIP-seq
MIRT1196151	hsa-miR-548ah	CLIP-seq
MIRT1196152	hsa-miR-550a	CLIP-seq
MIRT2056935	hsa-miR-566	CLIP-seq
MIRT2056936	hsa-miR-595	CLIP-seq
MIRT2056937	hsa-miR-617	CLIP-seq
MIRT1196156	hsa-miR-635	CLIP-seq
MIRT2056938	hsa-miR-646	CLIP-seq
MIRT2056939	hsa-miR-654-5p	CLIP-seq
MIRT2056940	hsa-miR-658	CLIP-seq
MIRT1196158	hsa-miR-661	CLIP-seq
MIRT2056941	hsa-miR-671-5p	CLIP-seq
MIRT2056942	hsa-miR-761	CLIP-seq
MIRT2056943	hsa-miR-762	CLIP-seq
MIRT2056944	hsa-miR-764	CLIP-seq
MIRT2056945	hsa-miR-885-3p	CLIP-seq
MIRT1196161	hsa-miR-920	CLIP-seq
MIRT1196162	hsa-miR-93	CLIP-seq
MIRT2056946	hsa-miR-943	CLIP-seq
MIRT2285352	hsa-miR-105	CLIP-seq
MIRT1196088	hsa-miR-1197	CLIP-seq
MIRT2285353	hsa-miR-1207-5p	CLIP-seq
MIRT2056891	hsa-miR-1294	CLIP-seq
MIRT2285354	hsa-miR-1470	CLIP-seq
MIRT2056892	hsa-miR-1587	CLIP-seq
MIRT2056893	hsa-miR-15a	CLIP-seq
MIRT2056894	hsa-miR-15b	CLIP-seq
MIRT2056895	hsa-miR-16	CLIP-seq
MIRT2056896	hsa-miR-1827	CLIP-seq
MIRT2285355	hsa-miR-188-5p	CLIP-seq
MIRT2056897	hsa-miR-1909	CLIP-seq
MIRT2056898	hsa-miR-195	CLIP-seq
MIRT2056900	hsa-miR-214	CLIP-seq
MIRT2285356	hsa-miR-2682	CLIP-seq
MIRT2056902	hsa-miR-296-5p	CLIP-seq
MIRT2056907	hsa-miR-3619-5p	CLIP-seq
MIRT2285357	hsa-miR-3663-3p	CLIP-seq
MIRT2056908	hsa-miR-3665	CLIP-seq
MIRT2285358	hsa-miR-3667-3p	CLIP-seq
MIRT2056909	hsa-miR-378g	CLIP-seq
MIRT2056910	hsa-miR-3907	CLIP-seq
MIRT2056911	hsa-miR-424	CLIP-seq
MIRT2285359	hsa-miR-4292	CLIP-seq
MIRT2056913	hsa-miR-4308	CLIP-seq
MIRT2056914	hsa-miR-4316	CLIP-seq
MIRT2285360	hsa-miR-4469	CLIP-seq
MIRT2056916	hsa-miR-4492	CLIP-seq
MIRT2056917	hsa-miR-4498	CLIP-seq
MIRT2285361	hsa-miR-449c	CLIP-seq
MIRT2056919	hsa-miR-4514	CLIP-seq
MIRT2285362	hsa-miR-4640-5p	CLIP-seq
MIRT2056923	hsa-miR-4656	CLIP-seq
MIRT2285363	hsa-miR-4667-3p	CLIP-seq
MIRT2056925	hsa-miR-4675	CLIP-seq
MIRT1196133	hsa-miR-4685-5p	CLIP-seq
MIRT1196134	hsa-miR-4688	CLIP-seq
MIRT2056926	hsa-miR-4692	CLIP-seq
MIRT2056927	hsa-miR-4694-3p	CLIP-seq
MIRT1196136	hsa-miR-4707-3p	CLIP-seq
MIRT1196138	hsa-miR-4725-5p	CLIP-seq
MIRT2285364	hsa-miR-4726-5p	CLIP-seq
MIRT2056928	hsa-miR-4741	CLIP-seq
MIRT2285365	hsa-miR-4763-3p	CLIP-seq
MIRT2056932	hsa-miR-497	CLIP-seq
MIRT1196145	hsa-miR-504	CLIP-seq
MIRT2056933	hsa-miR-522	CLIP-seq
MIRT2285366	hsa-miR-596	CLIP-seq
MIRT2056942	hsa-miR-761	CLIP-seq
MIRT2056943	hsa-miR-762	CLIP-seq
MIRT2056944	hsa-miR-764	CLIP-seq
MIRT2285367	hsa-miR-937	CLIP-seq
MIRT1196093	hsa-miR-1307	CLIP-seq
MIRT2056900	hsa-miR-214	CLIP-seq
MIRT2056907	hsa-miR-3619-5p	CLIP-seq
MIRT2056908	hsa-miR-3665	CLIP-seq
MIRT2056910	hsa-miR-3907	CLIP-seq
MIRT2056927	hsa-miR-4694-3p	CLIP-seq
MIRT1196136	hsa-miR-4707-3p	CLIP-seq
MIRT2056933	hsa-miR-522	CLIP-seq
MIRT2056935	hsa-miR-566	CLIP-seq
MIRT2056942	hsa-miR-761	CLIP-seq
MIRT2056944	hsa-miR-764	CLIP-seq
MIRT2583451	hsa-miR-1185	CLIP-seq
MIRT2583452	hsa-miR-1265	CLIP-seq
MIRT2056891	hsa-miR-1294	CLIP-seq
MIRT2583453	hsa-miR-1538	CLIP-seq
MIRT1196104	hsa-miR-299-3p	CLIP-seq
MIRT2583454	hsa-miR-3605-5p	CLIP-seq
MIRT2583455	hsa-miR-3679-5p	CLIP-seq
MIRT2583456	hsa-miR-4265	CLIP-seq
MIRT2583457	hsa-miR-4296	CLIP-seq
MIRT2056914	hsa-miR-4316	CLIP-seq
MIRT2583458	hsa-miR-4322	CLIP-seq
MIRT2056915	hsa-miR-4417	CLIP-seq
MIRT2285362	hsa-miR-4640-5p	CLIP-seq
MIRT2285364	hsa-miR-4726-5p	CLIP-seq
MIRT2583459	hsa-miR-4745-3p	CLIP-seq
MIRT2583460	hsa-miR-4747-3p	CLIP-seq
MIRT2583461	hsa-miR-4764-5p	CLIP-seq
MIRT2583451	hsa-miR-1185	CLIP-seq
MIRT2583452	hsa-miR-1265	CLIP-seq
MIRT2056891	hsa-miR-1294	CLIP-seq
MIRT2583453	hsa-miR-1538	CLIP-seq
MIRT1196104	hsa-miR-299-3p	CLIP-seq
MIRT2583454	hsa-miR-3605-5p	CLIP-seq
MIRT2583455	hsa-miR-3679-5p	CLIP-seq
MIRT2583456	hsa-miR-4265	CLIP-seq
MIRT2583457	hsa-miR-4296	CLIP-seq
MIRT2056914	hsa-miR-4316	CLIP-seq
MIRT2583458	hsa-miR-4322	CLIP-seq
MIRT2056915	hsa-miR-4417	CLIP-seq
MIRT2285362	hsa-miR-4640-5p	CLIP-seq
MIRT2285364	hsa-miR-4726-5p	CLIP-seq
MIRT2583459	hsa-miR-4745-3p	CLIP-seq
MIRT2583460	hsa-miR-4747-3p	CLIP-seq
MIRT2583461	hsa-miR-4764-5p	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0005515	Function	Protein binding	IPI	10102268, 19196994, 19721007, 20434207, 26190107, 28501620
GO:0005576	Component	Extracellular region	IDA	28945198
GO:0005576	Component	Extracellular region	TAS
GO:0005604	Component	Basement membrane	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006930	Process	Substrate-dependent cell migration, cell extension	ISS
GO:0007097	Process	Nuclear migration	IEA
GO:0007265	Process	Ras protein signal transduction	ISS
GO:0008045	Process	Motor neuron axon guidance	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009887	Process	Animal organ morphogenesis	IBA	21873635
GO:0009888	Process	Tissue development	IBA	21873635
GO:0016358	Process	Dendrite development	IBA	21873635
GO:0030334	Process	Regulation of cell migration	IEA
GO:0030517	Process	Negative regulation of axon extension	IEA
GO:0032488	Process	Cdc42 protein signal transduction	ISS
GO:0033564	Process	Anterior/posterior axon guidance	IEA
GO:0042472	Process	Inner ear morphogenesis	IEA
GO:0045773	Process	Positive regulation of axon extension	ISS
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0060603	Process	Mammary gland duct morphogenesis	IEA
GO:0061643	Process	Chemorepulsion of axon	ISS
GO:0098609	Process	Cell-cell adhesion	IEA
GO:1902842	Process	Negative regulation of netrin-activated signaling pathway	TAS
GO:2000147	Process	Positive regulation of cell motility	ISS

MIM	HGNC	e!Ensembl
601614	8029	ENSG00000065320

Protein

UniProt ID

O95631

Protein name

Netrin-1 (Epididymis tissue protein Li 131P)

Protein function

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from

PDB

4URT , 6FKQ , 7NDG , 7NE0 , 7NE1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00055	Laminin_N	51 → 283	Laminin N-terminal (Domain VI)	Family
PF00053	Laminin_EGF	285 → 338	Laminin EGF domain	Domain
PF00053	Laminin_EGF	341 → 401	Laminin EGF domain	Domain
PF00053	Laminin_EGF	404 → 451	Laminin EGF domain	Domain
PF01759	NTR	488 → 594	UNC-6/NTR/C345C module	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:2

Sequence

MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAF
GKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCW
QSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQD
WVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDD
SLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLS
GRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTT
GQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASK
GKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSR
DIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGK
CKKA

Sequence length

604

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Netrin-1 signaling DCC mediated attractive signaling

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Agenesis of corpus callosum	Agenesis of corpus callosum	rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Cerebral palsy	Cerebral Palsy	rs121918149, rs75184679, rs730880264, rs587777428, rs797045067, rs767399782, rs564185858, rs886039513
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Mental retardation	Mild Mental Retardation	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)
Mirror movements	Mirror movements disorder, MIRROR MOVEMENTS 4	rs199925463, rs34091239, rs606231254, rs1555429623, rs1567750186, rs1567749982, rs1567750187	28945198
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Evidence	Source
Unknown
Specific learning disorder	Specific learning disability		ClinVar
Multiple Congenital Anomalies	multiple congenital anomalies/dysmorphic syndrome		GenCC
Congenital Mirror Movements	familial congenital mirror movements		GenCC
Neuroticism	Neuroticism		GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Cleft Lip With Or Without Cleft Palate	Cleft Lip With Or Without Cleft Palate		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma		GWAS

Show/Hide Text Mining Associations (68)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	20007677, 38033740
Alzheimer Disease	Associate	32711556
Aortic Aneurysm Thoracic	Associate	31035427
Arthritis Rheumatoid	Inhibit	19822088
Atherosclerosis	Associate	32151395, 32317107
Bacterial Infections	Associate	40275124
beta Thalassemia	Stimulate	33715293
Bipolar Disorder	Associate	40597885
Brain Neoplasms	Associate	24647424
Breast Neoplasms	Associate	23319801, 27378792
Carcinogenesis	Associate	24647424, 27031829, 35489200
Carcinoma Hepatocellular	Stimulate	27031829
Carcinoma Hepatocellular	Associate	27420970
Carcinoma Non Small Cell Lung	Stimulate	24647424
Chemical and Drug Induced Liver Injury	Stimulate	27031829
Cleft Lip	Associate	35191549
Cleft Palate	Associate	23512105, 27734840, 30638414, 31122291, 35191549
Colorectal Neoplasms	Associate	18054557, 21893118, 26039999, 34470826, 37568074, 39261771
Colorectal Neoplasms	Inhibit	35489200
Coronary Artery Disease	Associate	27727089
Diabetes Gestational	Associate	30897795
Diabetes Mellitus Type 2	Associate	36297056
Diabetic Foot	Associate	40176590
Diabetic Nephropathies	Associate	38033740
Dyslexia	Associate	27734840
Fatty Liver	Associate	29985430
Fibrosis	Stimulate	27031829
Glioblastoma	Associate	21980448, 27651158
Glycosuria Renal	Associate	38033740
Graft vs Host Disease	Associate	26039999
Hepatitis C	Associate	27031829
Hodgkin Disease	Associate	40235169
Huntington Disease	Associate	26651603
Hypoxia	Stimulate	36297056
Inflammation	Associate	23666553, 24528886, 36297056, 40176590
Insulin Resistance	Associate	36297056
Kidney Diseases	Associate	33715293
Kidney Neoplasms	Associate	23526078
Leukemia Biphenotypic Acute	Associate	35974411
Leukemia Myeloid Acute	Associate	37038247
Liver Cirrhosis	Stimulate	27031829
Lung Neoplasms	Associate	35765995
Lymphatic Metastasis	Associate	39261771
Macular Degeneration	Associate	25950802
Medulloblastoma	Associate	24812271
Melanoma	Associate	19940358, 34470826, 36361539
Mitochondrial Diseases	Associate	32711556
Neoplasm Metastasis	Associate	23666553, 24528886, 37568074, 39261771
Neoplasms	Associate	19349462, 21789787, 23526078, 23666553, 24528886, 24812271, 25001177, 26039999, 27031829, 27378792, 36361539, 36587397, 37038247
Neoplasms	Stimulate	24647424, 34470826
Neoplasms	Inhibit	30917865
Neoplasms Adipose Tissue	Associate	36297056
Nerve Degeneration	Associate	36751943
Neuroblastoma	Associate	19349462
Obesity	Associate	36297056
Orofacial Cleft 1	Associate	28489749, 35191549
Osteoarthritis	Inhibit	19822088
Otofaciocervical Syndrome	Associate	35191549
Ovarian Neoplasms	Stimulate	21789787
Ovarian Neoplasms	Associate	37337170
Pancreatic Neoplasms	Associate	25001177
Parkinson Disease	Associate	36751943
Plasmablastic Lymphoma	Associate	40235169
Prostatitis	Associate	23666553
Semicircular Canal Dehiscence	Associate	22779713
Urinary Bladder Neoplasms	Associate	24528886, 32141538
Weight Loss	Inhibit	36297056
Xanthomatosis	Associate	40275124

NTN1 (netrin 1)