CD86 (CD86 molecule)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
942
Gene name Gene Name - the full gene name approved by the HGNC.
CD86 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD86
Synonyms (NCBI Gene) Gene synonyms aliases
B7-2, B7.2, B70, CD28LG2, LAB72
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(86)
miRTarBase ID miRNA Experiments Reference
MIRT021271 hsa-miR-146a-5p Other 20375304
MIRT022558 hsa-miR-124-3p Microarray 18668037
MIRT659681 hsa-miR-496 HITS-CLIP 23824327
MIRT659680 hsa-miR-3156-5p HITS-CLIP 23824327
MIRT639533 hsa-miR-6817-3p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
NFKB1 Activation 15895390;15949284;18929846;19164127
NFKB1 Unknown 10586028
RELA Activation 15895390;15949284;18929846;19164127
RELA Unknown 10586028
STAT1 Unknown 10773351
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(41)
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IEA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002639 Process Positive regulation of immunoglobulin production ISS
GO:0005515 Function Protein binding IPI 9915850, 11279501, 21982860, 25241761, 27708164
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601020 1705 ENSG00000114013
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P42081
Protein name T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
Protein function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation
PDB 1I85 , 1NCN , 5YXK , 8FXX , 8FXY , 8HXB , 8HXC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 24 → 132 Immunoglobulin V-set domain Domain
PF13895 Ig_2 138 → 236 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by activated B-lymphocytes and monocytes.
Sequence
Sequence length 329
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Virion - Adenovirus
Cell adhesion molecules
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Kaposi sarcoma-associated herpesvirus infection
Transcriptional misregulation in cancer
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis 		  PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Dementia Dementia N/A N/A GWAS
Follicular lymphoma Follicular lymphoma N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Systemic lupus erythematosus Systemic lupus erythematosus N/A N/A GWAS
Show/Hide Text Mining Associations (249)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 30942389
Achondroplasia and Swiss type agammaglobulinemia Associate 12823285
Acute On Chronic Liver Failure Inhibit 38111573
Adenocarcinoma of Lung Associate 26264617, 32616892, 36922519
Adrenoleukodystrophy Associate 29860501
Allergic Fungal Sinusitis Associate 26047816
Alzheimer Disease Associate 19849713
Anemia Aplastic Associate 35579089
Anemia Aplastic Stimulate 36334505
Arthritis Infectious Associate 21540807, 32849606