Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9416
Gene name Gene Name - the full gene name approved by the HGNC.	DEAD-box helicase 23
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DDX23
Synonyms (NCBI Gene) Gene synonyms aliases	PRPF28, SNRNP100, U5-100K, U5-100KD, prp28
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA second

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050352	hsa-miR-25-3p	CLASH	23622248
MIRT048936	hsa-miR-92a-3p	CLASH	23622248
MIRT045430	hsa-miR-149-5p	CLASH	23622248
MIRT044348	hsa-miR-106b-5p	CLASH	23622248
MIRT044059	hsa-miR-361-5p	CLASH	23622248
MIRT039941	hsa-miR-615-3p	CLASH	23622248
MIRT037450	hsa-miR-744-5p	CLASH	23622248
MIRT036357	hsa-miR-1229-3p	CLASH	23622248
MIRT736412	hsa-miR-21-3p	Luciferase reporter assay, Northern blotting	33311703
MIRT930271	hsa-miR-103b	CLIP-seq
MIRT930272	hsa-miR-1227	CLIP-seq
MIRT930273	hsa-miR-1301	CLIP-seq
MIRT930274	hsa-miR-1322	CLIP-seq
MIRT930275	hsa-miR-1913	CLIP-seq
MIRT930276	hsa-miR-217	CLIP-seq
MIRT930277	hsa-miR-2278	CLIP-seq
MIRT930278	hsa-miR-3064-5p	CLIP-seq
MIRT930279	hsa-miR-3065-3p	CLIP-seq
MIRT930280	hsa-miR-3120-3p	CLIP-seq
MIRT930281	hsa-miR-3135	CLIP-seq
MIRT930282	hsa-miR-3150a-3p	CLIP-seq
MIRT930283	hsa-miR-3160-3p	CLIP-seq
MIRT930284	hsa-miR-3175	CLIP-seq
MIRT930285	hsa-miR-324-3p	CLIP-seq
MIRT930286	hsa-miR-3622b-5p	CLIP-seq
MIRT930287	hsa-miR-3908	CLIP-seq
MIRT930288	hsa-miR-3941	CLIP-seq
MIRT930289	hsa-miR-4293	CLIP-seq
MIRT930290	hsa-miR-4313	CLIP-seq
MIRT930291	hsa-miR-4323	CLIP-seq
MIRT930292	hsa-miR-4418	CLIP-seq
MIRT930293	hsa-miR-4436b-3p	CLIP-seq
MIRT930294	hsa-miR-4487	CLIP-seq
MIRT930295	hsa-miR-450b-5p	CLIP-seq
MIRT930296	hsa-miR-4650-5p	CLIP-seq
MIRT930297	hsa-miR-4652-3p	CLIP-seq
MIRT930298	hsa-miR-466	CLIP-seq
MIRT930299	hsa-miR-4667-5p	CLIP-seq
MIRT930300	hsa-miR-4672	CLIP-seq
MIRT930301	hsa-miR-4700-5p	CLIP-seq
MIRT930302	hsa-miR-4720-5p	CLIP-seq
MIRT930303	hsa-miR-4758-3p	CLIP-seq
MIRT930304	hsa-miR-4761-3p	CLIP-seq
MIRT930305	hsa-miR-4799-3p	CLIP-seq
MIRT930306	hsa-miR-491-3p	CLIP-seq
MIRT930307	hsa-miR-5047	CLIP-seq
MIRT930308	hsa-miR-507	CLIP-seq
MIRT930309	hsa-miR-509-3-5p	CLIP-seq
MIRT930310	hsa-miR-509-5p	CLIP-seq
MIRT930311	hsa-miR-512-3p	CLIP-seq
MIRT930312	hsa-miR-556-5p	CLIP-seq
MIRT930313	hsa-miR-557	CLIP-seq
MIRT930314	hsa-miR-558	CLIP-seq
MIRT930315	hsa-miR-596	CLIP-seq
MIRT930316	hsa-miR-604	CLIP-seq
MIRT930317	hsa-miR-622	CLIP-seq
MIRT930318	hsa-miR-637	CLIP-seq
MIRT930319	hsa-miR-647	CLIP-seq
MIRT930320	hsa-miR-892b	CLIP-seq
MIRT930321	hsa-miR-935	CLIP-seq
MIRT930322	hsa-miR-939	CLIP-seq
MIRT1975371	hsa-miR-1294	CLIP-seq
MIRT1975372	hsa-miR-2277-3p	CLIP-seq
MIRT1975373	hsa-miR-3120-5p	CLIP-seq
MIRT1975374	hsa-miR-3123	CLIP-seq
MIRT1975375	hsa-miR-3607-3p	CLIP-seq
MIRT1975376	hsa-miR-3657	CLIP-seq
MIRT1975377	hsa-miR-3686	CLIP-seq
MIRT930287	hsa-miR-3908	CLIP-seq
MIRT1975378	hsa-miR-3919	CLIP-seq
MIRT1975379	hsa-miR-3978	CLIP-seq
MIRT1975380	hsa-miR-4276	CLIP-seq
MIRT1975381	hsa-miR-4287	CLIP-seq
MIRT1975382	hsa-miR-4316	CLIP-seq
MIRT1975383	hsa-miR-4330	CLIP-seq
MIRT1975384	hsa-miR-4426	CLIP-seq
MIRT1975385	hsa-miR-4436b-5p	CLIP-seq
MIRT1975386	hsa-miR-4469	CLIP-seq
MIRT1975387	hsa-miR-4504	CLIP-seq
MIRT1975388	hsa-miR-4645-3p	CLIP-seq
MIRT1975389	hsa-miR-4647	CLIP-seq
MIRT1975390	hsa-miR-4662b	CLIP-seq
MIRT1975391	hsa-miR-4676-5p	CLIP-seq
MIRT1975392	hsa-miR-4685-3p	CLIP-seq
MIRT1975393	hsa-miR-4755-3p	CLIP-seq
MIRT1975394	hsa-miR-4756-3p	CLIP-seq
MIRT1975395	hsa-miR-4764-5p	CLIP-seq
MIRT1975396	hsa-miR-500a	CLIP-seq
MIRT1975397	hsa-miR-570	CLIP-seq
MIRT1975398	hsa-miR-575	CLIP-seq
MIRT1975399	hsa-miR-583	CLIP-seq
MIRT1975400	hsa-miR-619	CLIP-seq
MIRT1975401	hsa-miR-875-3p	CLIP-seq
MIRT1975402	hsa-miR-942	CLIP-seq
MIRT1975374	hsa-miR-3123	CLIP-seq
MIRT930287	hsa-miR-3908	CLIP-seq
MIRT1975378	hsa-miR-3919	CLIP-seq
MIRT1975380	hsa-miR-4276	CLIP-seq
MIRT1975383	hsa-miR-4330	CLIP-seq
MIRT1975384	hsa-miR-4426	CLIP-seq
MIRT1975389	hsa-miR-4647	CLIP-seq
MIRT1975390	hsa-miR-4662b	CLIP-seq
MIRT1975391	hsa-miR-4676-5p	CLIP-seq
MIRT1975394	hsa-miR-4756-3p	CLIP-seq
MIRT1975397	hsa-miR-570	CLIP-seq
MIRT1975398	hsa-miR-575	CLIP-seq
MIRT1975402	hsa-miR-942	CLIP-seq
MIRT1975373	hsa-miR-3120-5p	CLIP-seq
MIRT1975375	hsa-miR-3607-3p	CLIP-seq
MIRT1975377	hsa-miR-3686	CLIP-seq
MIRT1975385	hsa-miR-4436b-5p	CLIP-seq
MIRT1975388	hsa-miR-4645-3p	CLIP-seq
MIRT1975396	hsa-miR-500a	CLIP-seq
MIRT2679150	hsa-miR-1343	CLIP-seq
MIRT2679151	hsa-miR-1976	CLIP-seq
MIRT1975373	hsa-miR-3120-5p	CLIP-seq
MIRT1975375	hsa-miR-3607-3p	CLIP-seq
MIRT1975377	hsa-miR-3686	CLIP-seq
MIRT1975385	hsa-miR-4436b-5p	CLIP-seq
MIRT1975388	hsa-miR-4645-3p	CLIP-seq
MIRT1975393	hsa-miR-4755-3p	CLIP-seq
MIRT2679152	hsa-miR-486-3p	CLIP-seq
MIRT1975396	hsa-miR-500a	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000354	Process	Cis assembly of pre-catalytic spliceosome	IC	9539711
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	9409622
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0000785	Component	Chromatin	IDA	28076779
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003724	Function	RNA helicase activity	TAS	9409622
GO:0004386	Function	Helicase activity	IDA	9539711
GO:0005515	Function	Protein binding	IPI	9774689, 20858735, 21044950, 26030138, 28514442
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	28076779
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005682	Component	U5 snRNP	IDA	9539711
GO:0005730	Component	Nucleolus	IDA
GO:0008380	Process	RNA splicing	TAS	9409622
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	9409622
GO:0062176	Process	R-loop disassembly	IDA	28076779
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0071013	Component	Catalytic step 2 spliceosome	IBA	21873635
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
612172	17347	ENSG00000174243

Protein

UniProt ID

Q9BUQ8

Protein name

Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)

Protein function

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops forme

PDB

3JCR , 4NHO , 6AH0 , 6QW6 , 6QX9 , 8H6E , 8H6J , 8Q7W , 8Q7X , 8Q91 , 8QOZ , 8QP8 , 8QP9 , 8QPA , 8QPB , 8QPK , 8QXD , 8R08 , 8R09 , 8R0A , 8R0B , 8RC0 , 8RM5 , 8Y6O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	415 → 616	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	650 → 759	Helicase conserved C-terminal domain	Family

Sequence

MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA

Sequence length

820

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Neurodevelopmental Disorders	neurodevelopmental disorder			GenCC

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Adenoid Cystic	Associate	28076779
Carcinoma Renal Cell	Associate	20121140
Myelodysplastic Syndromes	Associate	31855738
Neoplasms	Associate	28076779

DDX23 (DEAD-box helicase 23)