Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	94122
Gene name	Synaptotagmin like 5
Gene symbol	SYTL5
Synonyms (NCBI Gene)	slp5
Chromosome	X
Chromosome location	Xp11.4
Summary	The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a

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Show/Hide all (167)

miRTarBase ID	miRNA	Experiments
MIRT1407886	hsa-miR-1224-5p	CLIP-seq
MIRT1407887	hsa-miR-1304	CLIP-seq
MIRT1407888	hsa-miR-141	CLIP-seq
MIRT1407889	hsa-miR-190	CLIP-seq
MIRT1407890	hsa-miR-190b	CLIP-seq
MIRT1407891	hsa-miR-193a-3p	CLIP-seq
MIRT1407892	hsa-miR-193b	CLIP-seq
MIRT1407893	hsa-miR-200a	CLIP-seq
MIRT1407894	hsa-miR-3117-5p	CLIP-seq
MIRT1407895	hsa-miR-3133	CLIP-seq
MIRT1407896	hsa-miR-3176	CLIP-seq
MIRT1407897	hsa-miR-3200-3p	CLIP-seq
MIRT1407898	hsa-miR-3915	CLIP-seq
MIRT1407899	hsa-miR-3922-3p	CLIP-seq
MIRT1407900	hsa-miR-3928	CLIP-seq
MIRT1407901	hsa-miR-3944-5p	CLIP-seq
MIRT1407902	hsa-miR-4480	CLIP-seq
MIRT1407903	hsa-miR-4509	CLIP-seq
MIRT1407904	hsa-miR-455-5p	CLIP-seq
MIRT1407905	hsa-miR-4633-5p	CLIP-seq
MIRT1407906	hsa-miR-4639-5p	CLIP-seq
MIRT1407907	hsa-miR-4689	CLIP-seq
MIRT1407908	hsa-miR-4704-5p	CLIP-seq
MIRT1407909	hsa-miR-4744	CLIP-seq
MIRT1407910	hsa-miR-4759	CLIP-seq
MIRT1407911	hsa-miR-548a-5p	CLIP-seq
MIRT1407912	hsa-miR-548ab	CLIP-seq
MIRT1407913	hsa-miR-548ak	CLIP-seq
MIRT1407914	hsa-miR-548b-5p	CLIP-seq
MIRT1407915	hsa-miR-548c-5p	CLIP-seq
MIRT1407916	hsa-miR-548d-5p	CLIP-seq
MIRT1407917	hsa-miR-548h	CLIP-seq
MIRT1407918	hsa-miR-548i	CLIP-seq
MIRT1407919	hsa-miR-548j	CLIP-seq
MIRT1407920	hsa-miR-548k	CLIP-seq
MIRT1407921	hsa-miR-548l	CLIP-seq
MIRT1407922	hsa-miR-548w	CLIP-seq
MIRT1407923	hsa-miR-548y	CLIP-seq
MIRT1407924	hsa-miR-559	CLIP-seq
MIRT1407925	hsa-miR-1289	CLIP-seq
MIRT1407926	hsa-miR-150	CLIP-seq
MIRT1407927	hsa-miR-3198	CLIP-seq
MIRT1407928	hsa-miR-4294	CLIP-seq
MIRT1407929	hsa-miR-4309	CLIP-seq
MIRT1407930	hsa-miR-4534	CLIP-seq
MIRT1407931	hsa-miR-4713-5p	CLIP-seq
MIRT1407932	hsa-miR-4768-5p	CLIP-seq
MIRT1407933	hsa-miR-532-3p	CLIP-seq
MIRT1407934	hsa-miR-924	CLIP-seq
MIRT1407935	hsa-miR-1236	CLIP-seq
MIRT1407936	hsa-miR-1245	CLIP-seq
MIRT1407937	hsa-miR-1297	CLIP-seq
MIRT1407938	hsa-miR-1305	CLIP-seq
MIRT1407939	hsa-miR-137	CLIP-seq
MIRT1407888	hsa-miR-141	CLIP-seq
MIRT1407940	hsa-miR-1915	CLIP-seq
MIRT1407941	hsa-miR-199a-3p	CLIP-seq
MIRT1407942	hsa-miR-199b-3p	CLIP-seq
MIRT1407893	hsa-miR-200a	CLIP-seq
MIRT1407943	hsa-miR-203	CLIP-seq
MIRT1407944	hsa-miR-25	CLIP-seq
MIRT1407945	hsa-miR-26a	CLIP-seq
MIRT1407946	hsa-miR-26b	CLIP-seq
MIRT1407947	hsa-miR-3129-5p	CLIP-seq
MIRT1407948	hsa-miR-3151	CLIP-seq
MIRT1407949	hsa-miR-3182	CLIP-seq
MIRT1407950	hsa-miR-3194-3p	CLIP-seq
MIRT1407951	hsa-miR-32	CLIP-seq
MIRT1407952	hsa-miR-345	CLIP-seq
MIRT1407953	hsa-miR-3545-5p	CLIP-seq
MIRT1407954	hsa-miR-363	CLIP-seq
MIRT1407955	hsa-miR-367	CLIP-seq
MIRT1407956	hsa-miR-3909	CLIP-seq
MIRT1407957	hsa-miR-3913-3p	CLIP-seq
MIRT1407958	hsa-miR-4256	CLIP-seq
MIRT1407959	hsa-miR-4264	CLIP-seq
MIRT1407960	hsa-miR-4283	CLIP-seq
MIRT1407961	hsa-miR-4325	CLIP-seq
MIRT1407962	hsa-miR-4437	CLIP-seq
MIRT1407963	hsa-miR-4446-5p	CLIP-seq
MIRT1407964	hsa-miR-4465	CLIP-seq
MIRT1407965	hsa-miR-4489	CLIP-seq
MIRT1407966	hsa-miR-4519	CLIP-seq
MIRT1407967	hsa-miR-4635	CLIP-seq
MIRT1407968	hsa-miR-4659a-3p	CLIP-seq
MIRT1407969	hsa-miR-4659b-3p	CLIP-seq
MIRT1407970	hsa-miR-4724-3p	CLIP-seq
MIRT1407971	hsa-miR-4725-5p	CLIP-seq
MIRT1407972	hsa-miR-4726-3p	CLIP-seq
MIRT1407973	hsa-miR-4727-5p	CLIP-seq
MIRT1407974	hsa-miR-4733-5p	CLIP-seq
MIRT1407975	hsa-miR-4753-3p	CLIP-seq
MIRT1407932	hsa-miR-4768-5p	CLIP-seq
MIRT1407976	hsa-miR-4769-3p	CLIP-seq
MIRT1407977	hsa-miR-4797-3p	CLIP-seq
MIRT1407978	hsa-miR-485-3p	CLIP-seq
MIRT1407979	hsa-miR-489	CLIP-seq
MIRT1407980	hsa-miR-498	CLIP-seq
MIRT1407981	hsa-miR-504	CLIP-seq
MIRT1407982	hsa-miR-576-5p	CLIP-seq
MIRT1407983	hsa-miR-890	CLIP-seq
MIRT1407984	hsa-miR-92a	CLIP-seq
MIRT1407985	hsa-miR-92b	CLIP-seq
MIRT1407986	hsa-miR-936	CLIP-seq
MIRT2122296	hsa-miR-1178	CLIP-seq
MIRT2122297	hsa-miR-125a-3p	CLIP-seq
MIRT2122298	hsa-miR-1276	CLIP-seq
MIRT2122299	hsa-miR-1291	CLIP-seq
MIRT1407939	hsa-miR-137	CLIP-seq
MIRT1407888	hsa-miR-141	CLIP-seq
MIRT2122300	hsa-miR-149	CLIP-seq
MIRT2122301	hsa-miR-188-5p	CLIP-seq
MIRT1407940	hsa-miR-1915	CLIP-seq
MIRT1407941	hsa-miR-199a-3p	CLIP-seq
MIRT1407942	hsa-miR-199b-3p	CLIP-seq
MIRT1407893	hsa-miR-200a	CLIP-seq
MIRT2122302	hsa-miR-204	CLIP-seq
MIRT2122303	hsa-miR-211	CLIP-seq
MIRT1407944	hsa-miR-25	CLIP-seq
MIRT2122304	hsa-miR-3064-5p	CLIP-seq
MIRT2122305	hsa-miR-3074-3p	CLIP-seq
MIRT2122306	hsa-miR-3121-5p	CLIP-seq
MIRT2122307	hsa-miR-3127-3p	CLIP-seq
MIRT1407947	hsa-miR-3129-5p	CLIP-seq
MIRT1407948	hsa-miR-3151	CLIP-seq
MIRT2122308	hsa-miR-3163	CLIP-seq
MIRT1407950	hsa-miR-3194-3p	CLIP-seq
MIRT1407951	hsa-miR-32	CLIP-seq
MIRT2122309	hsa-miR-328	CLIP-seq
MIRT1407952	hsa-miR-345	CLIP-seq
MIRT1407954	hsa-miR-363	CLIP-seq
MIRT2122310	hsa-miR-3647-3p	CLIP-seq
MIRT2122311	hsa-miR-3653	CLIP-seq
MIRT1407955	hsa-miR-367	CLIP-seq
MIRT2122312	hsa-miR-3934	CLIP-seq
MIRT2122313	hsa-miR-411	CLIP-seq
MIRT2122314	hsa-miR-425	CLIP-seq
MIRT2122315	hsa-miR-4276	CLIP-seq
MIRT1407960	hsa-miR-4283	CLIP-seq
MIRT2122316	hsa-miR-4311	CLIP-seq
MIRT1407961	hsa-miR-4325	CLIP-seq
MIRT1407962	hsa-miR-4437	CLIP-seq
MIRT1407965	hsa-miR-4489	CLIP-seq
MIRT1407966	hsa-miR-4519	CLIP-seq
MIRT2122317	hsa-miR-451b	CLIP-seq
MIRT2122318	hsa-miR-4656	CLIP-seq
MIRT2122319	hsa-miR-4697-3p	CLIP-seq
MIRT1407971	hsa-miR-4725-5p	CLIP-seq
MIRT1407972	hsa-miR-4726-3p	CLIP-seq
MIRT1407973	hsa-miR-4727-5p	CLIP-seq
MIRT1407976	hsa-miR-4769-3p	CLIP-seq
MIRT2122320	hsa-miR-4794	CLIP-seq
MIRT1407979	hsa-miR-489	CLIP-seq
MIRT1407981	hsa-miR-504	CLIP-seq
MIRT2122321	hsa-miR-512-5p	CLIP-seq
MIRT2122322	hsa-miR-539	CLIP-seq
MIRT2122323	hsa-miR-545	CLIP-seq
MIRT2122324	hsa-miR-548m	CLIP-seq
MIRT2122325	hsa-miR-583	CLIP-seq
MIRT2122326	hsa-miR-617	CLIP-seq
MIRT2122327	hsa-miR-642b	CLIP-seq
MIRT2122328	hsa-miR-764	CLIP-seq
MIRT1407984	hsa-miR-92a	CLIP-seq
MIRT1407985	hsa-miR-92b	CLIP-seq
MIRT1407986	hsa-miR-936	CLIP-seq
MIRT2344562	hsa-miR-3617	CLIP-seq
MIRT2344563	hsa-miR-641	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12051743, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005543	Function	Phospholipid binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0042043	Function	Neurexin family protein binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0070382	Component	Exocytic vesicle	IBA

MIM	HGNC	e!Ensembl
301126	15589	ENSG00000147041

Q8TDW5

Protein name

Synaptotagmin-like protein 5

Protein function

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02318	FYVE_2	11 → 124	FYVE-type zinc finger	Family
PF00168	C2	421 → 529	C2 domain	Domain
PF00168	C2	587 → 696	C2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta and liver.

Sequence

MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA
SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF
FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG
PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND
QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS
HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET
EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT
GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT
ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG
LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT
AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL
TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM
LRSSMGKCRL

Sequence length

730

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANOREXIA NERVOSA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ERECTILE DYSFUNCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Laterality defects, autosomal dominant	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYTL5-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Anorexia Nervosa	Associate	23568457	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bulimia Nervosa	Associate	23568457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Stimulate	37207473	★★★★★ ★☆☆☆☆ Found in Text Mining only
Drug Related Side Effects and Adverse Reactions	Associate	27123591	★★★★★ ★☆☆☆☆ Found in Text Mining only
Feeding and Eating Disorders	Associate	23568457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Root Resorption	Associate	38546524	★★★★★ ★☆☆☆☆ Found in Text Mining only

SYTL5 (synaptotagmin like 5)