Gene Gene information from NCBI Gene database.
Entrez ID 94081
Gene name Sideroflexin 1
Gene symbol SFXN1
Synonyms (NCBI Gene)
SLC56A1TCC
Chromosome 5
Chromosome location 5q35.2
miRNA miRNA information provided by mirtarbase database.
955
miRTarBase ID miRNA Experiments Reference
MIRT001335 hsa-miR-1-3p pSILAC 18668040
MIRT001335 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001335 hsa-miR-1-3p Proteomics 18668040
MIRT030923 hsa-miR-21-5p Microarray 18591254
MIRT031779 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA
GO:0005739 Component Mitochondrion IEA
GO:0005743 Component Mitochondrial inner membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615569 16085 ENSG00000164466
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H9B4
Protein name Sideroflexin-1
Protein function Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03820 SFXNs 10 322 Sideroflexins Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney. {ECO:0000269|PubMed:30442778}.
Sequence
Sequence length 322
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Uncertain significance rs149270574 RCV005932692
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32819300
Adenocarcinoma of Lung Stimulate 38233752
Glioma Associate 27898674
Lymphatic Metastasis Stimulate 38233752
Neoplasms Associate 38233752
Schizophrenia Associate 34323598
Squamous Cell Carcinoma of Head and Neck Associate 35409173
Synovitis Associate 29968759
Thyroid Cancer Papillary Associate 34590520