Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9388
Gene name Gene Name - the full gene name approved by the HGNC.
Lipase G, endothelial type
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LIPG
Synonyms (NCBI Gene) Gene synonyms aliases
EDL, EL, PRO719
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017862 hsa-miR-335-5p Microarray 18185580
MIRT711648 hsa-miR-216a-5p HITS-CLIP 19536157
MIRT711647 hsa-miR-216b-5p HITS-CLIP 19536157
MIRT711646 hsa-miR-1228-3p HITS-CLIP 19536157
MIRT711645 hsa-miR-589-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004465 Function Lipoprotein lipase activity IBA 21873635
GO:0004620 Function Phospholipase activity IBA 21873635
GO:0004620 Function Phospholipase activity IDA 10192396
GO:0004806 Function Triglyceride lipase activity IDA 12032167
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603684 6623 ENSG00000101670
Protein
UniProt ID Q9Y5X9
Protein name Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32)
Protein function Exerts both phospholipase and triglyceride lipase activities (PubMed:10192396, PubMed:10318835, PubMed:12032167). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00151 Lipase 13 344 Lipase Domain
PF01477 PLAT 349 481 PLAT/LH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosar
Sequence
Sequence length 500
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Metabolic pathways
Cholesterol metabolism
  HDL remodeling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
30805717
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
22843504
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Testicular Germ Cell Tumor Testicular Germ Cell Tumor GWAS
Coronary artery disease Coronary artery disease GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 25291260
Adenocarcinoma of Lung Associate 36572999
Atherosclerosis Associate 15961789, 16177180, 16354105, 17093291, 17526978, 23991054, 25250890, 27430252
Breast Neoplasms Associate 30653260
Cardiovascular Diseases Associate 25250890
Carotid Stenosis Associate 21842303
Cholesterol pneumonia Associate 30369316
Colitis Ulcerative Associate 39596612
Colorectal Neoplasms Associate 28506205, 35108261
Coronary Artery Disease Associate 16354105, 17986713, 23243195, 26124511, 27600285, 27612170, 30150432