Gene Gene information from NCBI Gene database.
Entrez ID 9388
Gene name Lipase G, endothelial type
Gene symbol LIPG
Synonyms (NCBI Gene)
EDLELPRO719
Chromosome 18
Chromosome location 18q21.1
Summary The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which pro
miRNA miRNA information provided by mirtarbase database.
270
miRTarBase ID miRNA Experiments Reference
MIRT017862 hsa-miR-335-5p Microarray 18185580
MIRT711648 hsa-miR-216a-5p HITS-CLIP 19536157
MIRT711647 hsa-miR-216b-5p HITS-CLIP 19536157
MIRT711646 hsa-miR-1228-3p HITS-CLIP 19536157
MIRT711645 hsa-miR-589-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0004465 Function Lipoprotein lipase activity IBA
GO:0004465 Function Lipoprotein lipase activity IEA
GO:0004620 Function Phospholipase activity IDA 10192396
GO:0004620 Function Phospholipase activity IEA
GO:0004806 Function Triacylglycerol lipase activity IDA 12032167
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603684 6623 ENSG00000101670
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y5X9
Protein name Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32)
Protein function Exerts both phospholipase and triglyceride lipase activities (PubMed:10192396, PubMed:10318835, PubMed:12032167). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00151 Lipase 13 344 Lipase Domain
PF01477 PLAT 349 481 PLAT/LH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosar
Sequence
Sequence length 500
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Metabolic pathways
Cholesterol metabolism
  HDL remodeling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
13
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cholangiocarcinoma Benign rs201857867 RCV005928143
Clear cell carcinoma of kidney Benign rs61729805 RCV005904977
Colorectal cancer Uncertain significance rs777816384 RCV005924182
Familial cancer of breast Benign rs201857867 RCV005928141
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 25291260
Adenocarcinoma of Lung Associate 36572999
Atherosclerosis Associate 15961789, 16177180, 16354105, 17093291, 17526978, 23991054, 25250890, 27430252
Breast Neoplasms Associate 30653260
Cardiovascular Diseases Associate 25250890
Carotid Stenosis Associate 21842303
Cholesterol pneumonia Associate 30369316
Colitis Ulcerative Associate 39596612
Colorectal Neoplasms Associate 28506205, 35108261
Coronary Artery Disease Associate 16354105, 17986713, 23243195, 26124511, 27600285, 27612170, 30150432