Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9379
Gene name Gene Name - the full gene name approved by the HGNC.	Neurexin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NRXN2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the up

Show/Hide all(28)

miRTarBase ID	miRNA	Experiments
MIRT1194580	hsa-miR-1321	CLIP-seq
MIRT1194581	hsa-miR-3126-5p	CLIP-seq
MIRT1194582	hsa-miR-3160-3p	CLIP-seq
MIRT1194583	hsa-miR-3202	CLIP-seq
MIRT1194584	hsa-miR-4476	CLIP-seq
MIRT1194585	hsa-miR-4690-3p	CLIP-seq
MIRT1194586	hsa-miR-4739	CLIP-seq
MIRT1194587	hsa-miR-4756-5p	CLIP-seq
MIRT2056533	hsa-miR-1324	CLIP-seq
MIRT2056534	hsa-miR-1827	CLIP-seq
MIRT2056535	hsa-miR-2053	CLIP-seq
MIRT2056536	hsa-miR-4270	CLIP-seq
MIRT2056537	hsa-miR-4311	CLIP-seq
MIRT2056538	hsa-miR-4441	CLIP-seq
MIRT2056539	hsa-miR-4649-3p	CLIP-seq
MIRT2056540	hsa-miR-4773	CLIP-seq
MIRT2056541	hsa-miR-495	CLIP-seq
MIRT2056542	hsa-miR-544b	CLIP-seq
MIRT2056543	hsa-miR-642b	CLIP-seq
MIRT2686619	hsa-miR-1224-3p	CLIP-seq
MIRT2686620	hsa-miR-1260	CLIP-seq
MIRT2686621	hsa-miR-1260b	CLIP-seq
MIRT2686622	hsa-miR-1280	CLIP-seq
MIRT2686623	hsa-miR-1470	CLIP-seq
MIRT2686624	hsa-miR-3679-3p	CLIP-seq
MIRT2686625	hsa-miR-4469	CLIP-seq
MIRT2686626	hsa-miR-4667-3p	CLIP-seq
MIRT2686627	hsa-miR-532-3p	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	NAS	18923512
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005246	Function	Calcium channel regulator activity	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007158	Process	Neuron cell-cell adhesion	IEA
GO:0007158	Process	Neuron cell-cell adhesion	TAS	18923512
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	ISS
GO:0007165	Process	Signal transduction	NAS	18923512
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	ISS
GO:0007269	Process	Neurotransmitter secretion	IEA
GO:0007269	Process	Neurotransmitter secretion	ISS
GO:0007416	Process	Synapse assembly	IEA
GO:0007416	Process	Synapse assembly	ISS
GO:0016020	Component	Membrane	IEA
GO:0030534	Process	Adult behavior	IEA
GO:0030534	Process	Adult behavior	IMP	21424692
GO:0032991	Component	Protein-containing complex	IEA
GO:0035176	Process	Social behavior	IEA
GO:0035176	Process	Social behavior	IMP	21424692
GO:0042297	Process	Vocal learning	IEA
GO:0042297	Process	Vocal learning	IMP	21424692
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050839	Function	Cell adhesion molecule binding	IEA
GO:0050839	Function	Cell adhesion molecule binding	ISS
GO:0050839	Function	Cell adhesion molecule binding	TAS	18923512
GO:0071625	Process	Vocalization behavior	IEA
GO:0071625	Process	Vocalization behavior	IMP	21424692
GO:0097104	Process	Postsynaptic membrane assembly	IEA
GO:0097104	Process	Postsynaptic membrane assembly	ISS
GO:0097109	Function	Neuroligin family protein binding	IEA
GO:0097109	Function	Neuroligin family protein binding	ISS
GO:0097109	Function	Neuroligin family protein binding	TAS	18923512
GO:0097116	Process	Gephyrin clustering involved in postsynaptic density assembly	IEA
GO:0097116	Process	Gephyrin clustering involved in postsynaptic density assembly	ISS
GO:0097118	Process	Neuroligin clustering involved in postsynaptic membrane assembly	IEA
GO:0097118	Process	Neuroligin clustering involved in postsynaptic membrane assembly	ISS
GO:0097119	Process	Postsynaptic density protein 95 clustering	IEA
GO:0097119	Process	Postsynaptic density protein 95 clustering	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
600566	8009	ENSG00000110076

Protein

UniProt ID

P58401

Protein name

Neurexin-2-beta (Neurexin II-beta)

Protein function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

PDB

4NXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02210	Laminin_G_2	123 → 272	Laminin G domain	Domain
PF01034	Syndecan	582 → 640	Syndecan domain	Family

Sequence

MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTT
HHVHHFHSKHGTVPIAINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLA
VGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYH
VVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQL
TIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSV
LLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSD
DEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPP
AARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTL
LSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPT
SFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAA
ALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNK
DKEYYV

Sequence length

666

UniProt ID

Q9P2S2

Protein name

Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha)

Protein function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02210	Laminin_G_2	57 → 187	Laminin G domain	Domain
PF02210	Laminin_G_2	318 → 459	Laminin G domain	Domain
PF02210	Laminin_G_2	521 → 666	Laminin G domain	Domain
PF02210	Laminin_G_2	760 → 890	Laminin G domain	Domain
PF02210	Laminin_G_2	946 → 1074	Laminin G domain	Domain
PF02210	Laminin_G_2	1169 → 1318	Laminin G domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain.

Sequence

MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN
ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD
ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA
NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF
CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY
DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL
VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM
LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG
DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG
GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG
SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD
LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG
FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT
LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD
NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD
ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG
NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS
RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA
DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI
FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV
GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL
AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG
RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS
PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV
FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL
PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER
GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS
AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

Sequence length

1712

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		Neurexins and neuroligins

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Autism	autism	N/A	N/A	GenCC
Developmental And Epileptic Encephalopathy	Developmental and epileptic encephalopathy, 1	N/A	N/A	ClinVar
Gout	Gout	N/A	N/A	GWAS
Mental retardation	intellectual disability	N/A	N/A	ClinVar
Neurodevelopmental Disorders	neurodevelopmental disorder	N/A	N/A	GenCC

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autism Spectrum Disorder	Associate	22209245, 29703944
Autistic Disorder	Associate	30076746
Creutzfeldt Jakob Syndrome	Associate	25149502
Mental Disorders	Associate	30076746, 30976086
Migraine Disorders	Associate	34126933
Neoplasms	Inhibit	34777568
Nerve Degeneration	Associate	30902061
Parkinson Disease	Associate	33770142
Prion Diseases	Associate	25149502
Thyroid Neoplasms	Inhibit	34777568

NRXN2 (neurexin 2)