PPT2 (palmitoyl-protein thioesterase 2)

Gene

• Entrez ID: 9374
• Gene name: Palmitoyl-protein thioesterase 2
• Gene symbol: PPT2
• Synonyms (NCBI Gene): C6orf8, G14, PPT-2
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027637	hsa-miR-98-5p	Microarray	19088304
MIRT1259204	hsa-miR-2114	CLIP-seq
MIRT1259205	hsa-miR-3132	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT1259208	hsa-miR-642a	CLIP-seq
MIRT1259209	hsa-miR-1200	CLIP-seq
MIRT1259210	hsa-miR-1254	CLIP-seq
MIRT1259211	hsa-miR-1303	CLIP-seq
MIRT1259212	hsa-miR-141	CLIP-seq
MIRT1259213	hsa-miR-150	CLIP-seq
MIRT1259214	hsa-miR-15a	CLIP-seq
MIRT1259215	hsa-miR-15b	CLIP-seq
MIRT1259216	hsa-miR-16	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259218	hsa-miR-1915	CLIP-seq
MIRT1259219	hsa-miR-195	CLIP-seq
MIRT1259220	hsa-miR-200a	CLIP-seq
MIRT1259204	hsa-miR-2114	CLIP-seq
MIRT1259221	hsa-miR-2467-3p	CLIP-seq
MIRT1259222	hsa-miR-2861	CLIP-seq
MIRT1259223	hsa-miR-2964a-5p	CLIP-seq
MIRT1259224	hsa-miR-3116	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259226	hsa-miR-3123	CLIP-seq
MIRT1259227	hsa-miR-3125	CLIP-seq
MIRT1259205	hsa-miR-3132	CLIP-seq
MIRT1259228	hsa-miR-3145-5p	CLIP-seq
MIRT1259229	hsa-miR-3179	CLIP-seq
MIRT1259230	hsa-miR-3202	CLIP-seq
MIRT1259231	hsa-miR-3677-5p	CLIP-seq
MIRT1259232	hsa-miR-3916	CLIP-seq
MIRT1259233	hsa-miR-3925-5p	CLIP-seq
MIRT1259234	hsa-miR-424	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT1259235	hsa-miR-4324	CLIP-seq
MIRT1259236	hsa-miR-4428	CLIP-seq
MIRT1259237	hsa-miR-4468	CLIP-seq
MIRT1259238	hsa-miR-4475	CLIP-seq
MIRT1259239	hsa-miR-4476	CLIP-seq
MIRT1259240	hsa-miR-4481	CLIP-seq
MIRT1259241	hsa-miR-4512	CLIP-seq
MIRT1259242	hsa-miR-4533	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT1259243	hsa-miR-4652-5p	CLIP-seq
MIRT1259244	hsa-miR-4691-3p	CLIP-seq
MIRT1259245	hsa-miR-4713-5p	CLIP-seq
MIRT1259246	hsa-miR-4726-3p	CLIP-seq
MIRT1259247	hsa-miR-4745-5p	CLIP-seq
MIRT1259248	hsa-miR-4758-5p	CLIP-seq
MIRT1259249	hsa-miR-497	CLIP-seq
MIRT1259250	hsa-miR-508-5p	CLIP-seq
MIRT1259251	hsa-miR-515-5p	CLIP-seq
MIRT1259252	hsa-miR-532-3p	CLIP-seq
MIRT1259253	hsa-miR-541	CLIP-seq
MIRT1259254	hsa-miR-544b	CLIP-seq
MIRT1259255	hsa-miR-545	CLIP-seq
MIRT1259256	hsa-miR-548ac	CLIP-seq
MIRT1259257	hsa-miR-548ae	CLIP-seq
MIRT1259258	hsa-miR-548aj	CLIP-seq
MIRT1259259	hsa-miR-548am	CLIP-seq
MIRT1259260	hsa-miR-548d-3p	CLIP-seq
MIRT1259261	hsa-miR-548p	CLIP-seq
MIRT1259262	hsa-miR-548x	CLIP-seq
MIRT1259263	hsa-miR-548z	CLIP-seq
MIRT1259264	hsa-miR-583	CLIP-seq
MIRT1259208	hsa-miR-642a	CLIP-seq
MIRT1259265	hsa-miR-645	CLIP-seq
MIRT1259266	hsa-miR-654-5p	CLIP-seq
MIRT1259267	hsa-miR-661	CLIP-seq
MIRT1259268	hsa-miR-765	CLIP-seq
MIRT2076384	hsa-miR-1234	CLIP-seq
MIRT1259210	hsa-miR-1254	CLIP-seq
MIRT2076385	hsa-miR-1275	CLIP-seq
MIRT1259211	hsa-miR-1303	CLIP-seq
MIRT1259212	hsa-miR-141	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259220	hsa-miR-200a	CLIP-seq
MIRT1259204	hsa-miR-2114	CLIP-seq
MIRT2076386	hsa-miR-219-2-3p	CLIP-seq
MIRT2076387	hsa-miR-2355-5p	CLIP-seq
MIRT1259223	hsa-miR-2964a-5p	CLIP-seq
MIRT1259224	hsa-miR-3116	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259226	hsa-miR-3123	CLIP-seq
MIRT1259205	hsa-miR-3132	CLIP-seq
MIRT2076388	hsa-miR-3689a-3p	CLIP-seq
MIRT2076389	hsa-miR-3689c	CLIP-seq
MIRT1259233	hsa-miR-3925-5p	CLIP-seq
MIRT2076390	hsa-miR-3938	CLIP-seq
MIRT2076391	hsa-miR-4259	CLIP-seq
MIRT2076392	hsa-miR-4266	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT2076393	hsa-miR-4425	CLIP-seq
MIRT2076394	hsa-miR-4446-3p	CLIP-seq
MIRT2076395	hsa-miR-4525	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT1259243	hsa-miR-4652-5p	CLIP-seq
MIRT2076396	hsa-miR-4656	CLIP-seq
MIRT2076397	hsa-miR-4665-3p	CLIP-seq
MIRT2076398	hsa-miR-4665-5p	CLIP-seq
MIRT2076399	hsa-miR-4712-3p	CLIP-seq
MIRT2076400	hsa-miR-4721	CLIP-seq
MIRT2076401	hsa-miR-4723-5p	CLIP-seq
MIRT2076402	hsa-miR-4728-5p	CLIP-seq
MIRT2076403	hsa-miR-4802-5p	CLIP-seq
MIRT2076404	hsa-miR-490-5p	CLIP-seq
MIRT2076405	hsa-miR-571	CLIP-seq
MIRT2076406	hsa-miR-616	CLIP-seq
MIRT2076407	hsa-miR-625	CLIP-seq
MIRT1259208	hsa-miR-642a	CLIP-seq
MIRT2076408	hsa-miR-939	CLIP-seq
MIRT2076385	hsa-miR-1275	CLIP-seq
MIRT1259212	hsa-miR-141	CLIP-seq
MIRT1259213	hsa-miR-150	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259218	hsa-miR-1915	CLIP-seq
MIRT2303054	hsa-miR-196a	CLIP-seq
MIRT2303055	hsa-miR-196b	CLIP-seq
MIRT1259220	hsa-miR-200a	CLIP-seq
MIRT1259222	hsa-miR-2861	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259228	hsa-miR-3145-5p	CLIP-seq
MIRT2303056	hsa-miR-3199	CLIP-seq
MIRT2303057	hsa-miR-3591-3p	CLIP-seq
MIRT2303058	hsa-miR-4272	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT2303059	hsa-miR-4515	CLIP-seq
MIRT2076395	hsa-miR-4525	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT2076398	hsa-miR-4665-5p	CLIP-seq
MIRT1259245	hsa-miR-4713-5p	CLIP-seq
MIRT2076401	hsa-miR-4723-5p	CLIP-seq
MIRT1259246	hsa-miR-4726-3p	CLIP-seq
MIRT1259250	hsa-miR-508-5p	CLIP-seq
MIRT1259252	hsa-miR-532-3p	CLIP-seq
MIRT2303060	hsa-miR-548m	CLIP-seq
MIRT2076407	hsa-miR-625	CLIP-seq
MIRT2303061	hsa-miR-637	CLIP-seq
MIRT1259265	hsa-miR-645	CLIP-seq
MIRT2076408	hsa-miR-939	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT1259238	hsa-miR-4475	CLIP-seq
MIRT2076408	hsa-miR-939	CLIP-seq
MIRT2442504	hsa-miR-3160-5p	CLIP-seq
MIRT2442505	hsa-miR-326	CLIP-seq
MIRT2442506	hsa-miR-330-5p	CLIP-seq
MIRT2442507	hsa-miR-3614-5p	CLIP-seq
MIRT2442508	hsa-miR-378	CLIP-seq
MIRT2442509	hsa-miR-378b	CLIP-seq
MIRT2442510	hsa-miR-378c	CLIP-seq
MIRT2442511	hsa-miR-378d	CLIP-seq
MIRT2442512	hsa-miR-378e	CLIP-seq
MIRT2442513	hsa-miR-378f	CLIP-seq
MIRT2442514	hsa-miR-378h	CLIP-seq
MIRT2442515	hsa-miR-378i	CLIP-seq
MIRT2442516	hsa-miR-3913-3p	CLIP-seq
MIRT2442517	hsa-miR-3922-5p	CLIP-seq
MIRT2442518	hsa-miR-422a	CLIP-seq
MIRT2442519	hsa-miR-4638-3p	CLIP-seq
MIRT2442520	hsa-miR-4686	CLIP-seq
MIRT2442521	hsa-miR-4717-5p	CLIP-seq
MIRT2442522	hsa-miR-4753-5p	CLIP-seq
MIRT2442523	hsa-miR-489	CLIP-seq
MIRT2442524	hsa-miR-593	CLIP-seq
MIRT1259211	hsa-miR-1303	CLIP-seq
MIRT2599786	hsa-miR-151-5p	CLIP-seq
MIRT2599787	hsa-miR-151b	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259204	hsa-miR-2114	CLIP-seq
MIRT1259223	hsa-miR-2964a-5p	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259226	hsa-miR-3123	CLIP-seq
MIRT1259205	hsa-miR-3132	CLIP-seq
MIRT2442504	hsa-miR-3160-5p	CLIP-seq
MIRT2442505	hsa-miR-326	CLIP-seq
MIRT2442506	hsa-miR-330-5p	CLIP-seq
MIRT2442507	hsa-miR-3614-5p	CLIP-seq
MIRT2076388	hsa-miR-3689a-3p	CLIP-seq
MIRT2076389	hsa-miR-3689c	CLIP-seq
MIRT2442508	hsa-miR-378	CLIP-seq
MIRT2442509	hsa-miR-378b	CLIP-seq
MIRT2442510	hsa-miR-378c	CLIP-seq
MIRT2442511	hsa-miR-378d	CLIP-seq
MIRT2442512	hsa-miR-378e	CLIP-seq
MIRT2442513	hsa-miR-378f	CLIP-seq
MIRT2442514	hsa-miR-378h	CLIP-seq
MIRT2442515	hsa-miR-378i	CLIP-seq
MIRT2442516	hsa-miR-3913-3p	CLIP-seq
MIRT2442517	hsa-miR-3922-5p	CLIP-seq
MIRT1259233	hsa-miR-3925-5p	CLIP-seq
MIRT2442518	hsa-miR-422a	CLIP-seq
MIRT2076391	hsa-miR-4259	CLIP-seq
MIRT2076392	hsa-miR-4266	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT2076393	hsa-miR-4425	CLIP-seq
MIRT2076394	hsa-miR-4446-3p	CLIP-seq
MIRT2442519	hsa-miR-4638-3p	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT1259243	hsa-miR-4652-5p	CLIP-seq
MIRT2076396	hsa-miR-4656	CLIP-seq
MIRT2442520	hsa-miR-4686	CLIP-seq
MIRT2442521	hsa-miR-4717-5p	CLIP-seq
MIRT2076400	hsa-miR-4721	CLIP-seq
MIRT2076402	hsa-miR-4728-5p	CLIP-seq
MIRT2442522	hsa-miR-4753-5p	CLIP-seq
MIRT2442523	hsa-miR-489	CLIP-seq
MIRT2076405	hsa-miR-571	CLIP-seq
MIRT2442524	hsa-miR-593	CLIP-seq
MIRT1259208	hsa-miR-642a	CLIP-seq
MIRT2076408	hsa-miR-939	CLIP-seq
MIRT1259217	hsa-miR-191	CLIP-seq
MIRT1259204	hsa-miR-2114	CLIP-seq
MIRT1259223	hsa-miR-2964a-5p	CLIP-seq
MIRT1259225	hsa-miR-3117-5p	CLIP-seq
MIRT1259205	hsa-miR-3132	CLIP-seq
MIRT2442504	hsa-miR-3160-5p	CLIP-seq
MIRT2442505	hsa-miR-326	CLIP-seq
MIRT2442506	hsa-miR-330-5p	CLIP-seq
MIRT2442507	hsa-miR-3614-5p	CLIP-seq
MIRT2076388	hsa-miR-3689a-3p	CLIP-seq
MIRT2076389	hsa-miR-3689c	CLIP-seq
MIRT2442508	hsa-miR-378	CLIP-seq
MIRT2442509	hsa-miR-378b	CLIP-seq
MIRT2442510	hsa-miR-378c	CLIP-seq
MIRT2442511	hsa-miR-378d	CLIP-seq
MIRT2442512	hsa-miR-378e	CLIP-seq
MIRT2442513	hsa-miR-378f	CLIP-seq
MIRT2442514	hsa-miR-378h	CLIP-seq
MIRT2442515	hsa-miR-378i	CLIP-seq
MIRT2442516	hsa-miR-3913-3p	CLIP-seq
MIRT2442517	hsa-miR-3922-5p	CLIP-seq
MIRT2442518	hsa-miR-422a	CLIP-seq
MIRT2076391	hsa-miR-4259	CLIP-seq
MIRT2076392	hsa-miR-4266	CLIP-seq
MIRT1259206	hsa-miR-4286	CLIP-seq
MIRT2076393	hsa-miR-4425	CLIP-seq
MIRT2076394	hsa-miR-4446-3p	CLIP-seq
MIRT2442519	hsa-miR-4638-3p	CLIP-seq
MIRT1259207	hsa-miR-4639-3p	CLIP-seq
MIRT1259243	hsa-miR-4652-5p	CLIP-seq
MIRT2076396	hsa-miR-4656	CLIP-seq
MIRT2442520	hsa-miR-4686	CLIP-seq
MIRT2442521	hsa-miR-4717-5p	CLIP-seq
MIRT2076400	hsa-miR-4721	CLIP-seq
MIRT2076402	hsa-miR-4728-5p	CLIP-seq
MIRT2442522	hsa-miR-4753-5p	CLIP-seq
MIRT2442523	hsa-miR-489	CLIP-seq
MIRT2076405	hsa-miR-571	CLIP-seq
MIRT2442524	hsa-miR-593	CLIP-seq
MIRT1259208	hsa-miR-642a	CLIP-seq
MIRT2076408	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IBA
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	NAS	9341199
GO:0016787	Function	Hydrolase activity	IEA
GO:0016790	Function	Thiolester hydrolase activity	IDA	10417332
GO:0016790	Function	Thiolester hydrolase activity	NAS	9341199
GO:0043202	Component	Lysosomal lumen	TAS
GO:0046949	Process	Fatty-acyl-CoA biosynthetic process	TAS
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IDA	9341199
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098599	Function	Palmitoyl hydrolase activity	IBA
GO:0098599	Function	Palmitoyl hydrolase activity	IDA	9341199, 10417332
GO:0098599	Function	Palmitoyl hydrolase activity	IEA
GO:0098599	Function	Palmitoyl hydrolase activity	TAS
GO:0098734	Process	Macromolecule depalmitoylation	IEA

Other IDs

• MIM: 603298
• HGNC: 9326
• e!Ensembl: ENSG00000221988

Protein

• UniProt ID: Q9UMR5
• Protein name: Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.2) (Palmitoyl-protein thioesterase 2) (S-thioesterase G14)
• Protein function: Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Co
• PDB: 1PJA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02089	Palm_thioest	38 → 283		Domain

• Tissue specificity: TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:9341199}.
• Sequence:

  MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYIN
  ETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRAL
  LSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWH
  DPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFG
  FYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPW
  LS

• Sequence length: 302

Pathways

KEGG:

Fatty acid elongation
Metabolic pathways
Fatty acid metabolism
Lysosome

Reactome:

Fatty acyl-CoA biosynthesis