Gene Gene information from NCBI Gene database.
Entrez ID 93663
Gene name Rho GTPase activating protein 18
Gene symbol ARHGAP18
Synonyms (NCBI Gene)
MacGAPSENEXbA307O14.2
Chromosome 6
Chromosome location 6q22.33
Summary ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
miRNA miRNA information provided by mirtarbase database.
449
miRTarBase ID miRNA Experiments Reference
MIRT610626 hsa-miR-2681-3p HITS-CLIP 23824327
MIRT610625 hsa-miR-5187-3p HITS-CLIP 23824327
MIRT610624 hsa-miR-581 HITS-CLIP 23824327
MIRT610623 hsa-miR-15b-3p HITS-CLIP 23824327
MIRT610622 hsa-miR-4513 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IDA 28251925
GO:0005096 Function GTPase activator activity IBA
GO:0005096 Function GTPase activator activity IEA
GO:0005096 Function GTPase activator activity IMP 21865595
GO:0005096 Function GTPase activator activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613351 21035 ENSG00000146376
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N392
Protein name Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)
Protein function Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00620 RhoGAP 343 493 RhoGAP domain Domain
Sequence
MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPP
FDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLS
NLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRE
SKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQA
LNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYD
VLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLET
EGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYL
KAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAM
VMAPNLFMCHALG
LKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTEN
HKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELK
ASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKS
KPL
Sequence length 663
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
9
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs34390841 RCV005913171
ARHGAP18-related disorder Likely benign rs577070164 RCV003914589
Clear cell carcinoma of kidney Benign rs34390841 RCV005913172
Colon adenocarcinoma Uncertain significance rs150003221 RCV005929179
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 28829761
Carcinogenesis Associate 24505313
Crohn Disease Associate 33973626
Glucocorticoid Receptor Deficiency Associate 34262023
Glucosephosphate Dehydrogenase Deficiency Associate 20664062
Inflammation Inhibit 20664062
Lymphoma Large B Cell Diffuse Associate 31327185, 33015970
Neoplasm Invasiveness Associate 28829761
Neoplasm Metastasis Associate 24505313, 30510148
Neoplasms Associate 28829761