Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
93663
Gene name Gene Name - the full gene name approved by the HGNC.
Rho GTPase activating protein 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARHGAP18
Synonyms (NCBI Gene) Gene synonyms aliases
MacGAP, SENEX, bA307O14.2
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q22.33
Summary Summary of gene provided in NCBI Entrez Gene.
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT610626 hsa-miR-2681-3p HITS-CLIP 23824327
MIRT610625 hsa-miR-5187-3p HITS-CLIP 23824327
MIRT610624 hsa-miR-581 HITS-CLIP 23824327
MIRT610623 hsa-miR-15b-3p HITS-CLIP 23824327
MIRT610622 hsa-miR-4513 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IDA 28251925
GO:0005096 Function GTPase activator activity IBA 21873635
GO:0005096 Function GTPase activator activity IMP 21865595
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IMP 21865595
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613351 21035 ENSG00000146376
Protein
UniProt ID Q8N392
Protein name Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)
Protein function Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00620 RhoGAP 343 493 RhoGAP domain Domain
Sequence
MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPP
FDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLS
NLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRE
SKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQA
LNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYD
VLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLET
EGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYL
KAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAM
VMAPNLFMCHALG
LKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTEN
HKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELK
ASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKS
KPL
Sequence length 663
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19065146
Unknown
Disease term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma GWAS
Renal Carcinoma Renal Carcinoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 28829761
Carcinogenesis Associate 24505313
Crohn Disease Associate 33973626
Glucocorticoid Receptor Deficiency Associate 34262023
Glucosephosphate Dehydrogenase Deficiency Associate 20664062
Inflammation Inhibit 20664062
Lymphoma Large B Cell Diffuse Associate 31327185, 33015970
Neoplasm Invasiveness Associate 28829761
Neoplasm Metastasis Associate 24505313, 30510148
Neoplasms Associate 28829761