ARHGAP18 (Rho GTPase activating protein 18)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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93663 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Rho GTPase activating protein 18 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ARHGAP18 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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MacGAP, SENEX, bA307O14.2 |
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Chromosome
Chromosome number
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6 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6q22.33 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q8N392 | ||||||||||
| Protein name | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | ||||||||||
| Protein function | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 663 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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