ARHGAP18 (Rho GTPase activating protein 18)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 93663 |
| Gene name | Rho GTPase activating protein 18 |
| Gene symbol | ARHGAP18 |
| Synonyms (NCBI Gene) |
MacGAPSENEXbA307O14.2
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| Chromosome | 6 |
| Chromosome location | 6q22.33 |
| Summary | ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010] |
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miRNA
miRNA information provided by mirtarbase database.
449
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N392 | ||||||||||
| Protein name | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | ||||||||||
| Protein function | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 663 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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