Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9349
Gene name	Ribosomal protein L23
Gene symbol	RPL23
Synonyms (NCBI Gene)	L23rpL17uL14
Chromosome	17
Chromosome location	17q12
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022730	hsa-miR-124-3p	Microarray	18668037
MIRT047046	hsa-miR-183-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT039746	hsa-miR-615-3p	CLASH	23622248
MIRT052822	hsa-miR-3200-3p	CLASH	23622248
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT2318586	hsa-miR-1243	CLIP-seq
MIRT2318587	hsa-miR-3654	CLIP-seq
MIRT2318588	hsa-miR-4434	CLIP-seq
MIRT2318589	hsa-miR-4506	CLIP-seq
MIRT2318590	hsa-miR-4516	CLIP-seq
MIRT2318591	hsa-miR-4531	CLIP-seq
MIRT2318592	hsa-miR-520d-5p	CLIP-seq
MIRT2318593	hsa-miR-524-5p	CLIP-seq
MIRT2318594	hsa-miR-629	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19160485
GO:0001223	Function	Transcription coactivator binding	IPI	19160485
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	15314173, 16189514, 17110929, 17310983, 25416956, 30021884, 32296183, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA	15314173
GO:0005730	Component	Nucleolus	IDA	15314173, 19160485
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	15314173
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	1874450
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006610	Process	Ribosomal protein import into nucleus	NAS	1874450
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19160485
GO:0010628	Process	Positive regulation of gene expression	IMP	15314173
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15314173
GO:0032986	Process	Protein-DNA complex disassembly	IDA	19160485
GO:0032991	Component	Protein-containing complex	IDA	19160485
GO:0032991	Component	Protein-containing complex	IMP	15314173
GO:0045202	Component	Synapse	IEA
GO:0050821	Process	Protein stabilization	IMP	15314173, 19160485
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA
GO:0070314	Process	G1 to G0 transition	IMP	19160485
GO:0072717	Process	Cellular response to actinomycin D	IMP	15314173
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IMP	15314173
GO:1903450	Process	Regulation of G1 to G0 transition	IMP	15314173
GO:1904667	Process	Negative regulation of ubiquitin protein ligase activity	IDA	15314173
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	15314173
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	15314173

MIM	HGNC	e!Ensembl
603662	10316	ENSG00000125691

P62829

Protein name

Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00238	Ribosomal_L14	20 → 140	Ribosomal protein L14p/L23e	Domain

Sequence

MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDM
VMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGP
VAKECADLWPRIASNAGSIA

Sequence length

140

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Uncertain significance	rs531763616	RCV005931381

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	35766008
Arthritis Reactive	Associate	8790600
Atypical Hemolytic Uremic Syndrome	Associate	37373158
Colorectal Neoplasms	Associate	36341526
HIV Infections	Associate	32579550
Infertility Male	Associate	36369953
Mucopolysaccharidoses	Associate	35456399
Myelodysplastic Syndromes	Associate	28539603
Sarcoma Kaposi	Associate	40016701
Sertoli Cell Only Syndrome	Associate	31603917
Venous Thromboembolism	Associate	29620629

RPL23 (ribosomal protein L23)