Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9348
Gene name Gene Name - the full gene name approved by the HGNC.
N-deacetylase and N-sulfotransferase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NDST3
Synonyms (NCBI Gene) Gene synonyms aliases
HSST3
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q26
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacet
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017221 hsa-miR-335-5p Microarray 18185580
MIRT635660 hsa-miR-4695-5p HITS-CLIP 23824327
MIRT635659 hsa-miR-889-5p HITS-CLIP 23824327
MIRT635658 hsa-miR-6736-3p HITS-CLIP 23824327
MIRT635657 hsa-miR-4768-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005575 Component Cellular_component ND
GO:0005794 Component Golgi apparatus IBA 21873635
GO:0015012 Process Heparan sulfate proteoglycan biosynthetic process IDA 9915799
GO:0015014 Process Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603950 7682 ENSG00000164100
Protein
UniProt ID O95803
Protein name Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan su
Protein function Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated hepa
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12062 HSNSD 20 506 heparan sulfate-N-deacetylase Family
PF00685 Sulfotransfer_1 595 858 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle. {ECO:0000269|PubMed:9915799}.
Sequence
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPY
QLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVL
IDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGF
PFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKT
PENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLS
LDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEE
EDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAV
APHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLF
THTIFYKEYPGGPKELDKSIQGGELF
FTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANF
VKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLV
IGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVT
TDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFS
FYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVM
DEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLS
SYYRDHNVELSKLLHKLG
QPLPSWLRQELQKVR
Sequence length 873
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
  HS-GAG biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Narcolepsy Narcolepsy rs104894574, rs387906655 19629137
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
25139529, 24253340
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Restless Legs Syndrome Restless Legs Syndrome GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36135988
Amyotrophic Lateral Sclerosis Associate 36135988
Bipolar Disorder Associate 24253340, 36135988
Carcinoma Renal Cell Associate 33836688
Frontotemporal Dementia Associate 36135988
Glioma Associate 34284545
Heredodegenerative Disorders Nervous System Associate 36135988
Liver Neoplasms Associate 36135988
Neoplasm Metastasis Associate 34284545
Neoplasms Associate 34284545