Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9340
Gene name Gene Name - the full gene name approved by the HGNC.	Glucagon like peptide 2 receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GLP2R
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomita

Show/Hide all(157)

miRTarBase ID	miRNA	Experiments	Reference
MIRT696128	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT696127	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT696126	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT696125	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696124	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT696123	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT696122	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696121	hsa-miR-3926	HITS-CLIP	23313552
MIRT696120	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT696119	hsa-miR-548s	HITS-CLIP	23313552
MIRT682518	hsa-miR-15a-5p	HITS-CLIP	23706177
MIRT682517	hsa-miR-15b-5p	HITS-CLIP	23706177
MIRT682516	hsa-miR-16-5p	HITS-CLIP	23706177
MIRT682515	hsa-miR-195-5p	HITS-CLIP	23706177
MIRT682514	hsa-miR-424-5p	HITS-CLIP	23706177
MIRT682513	hsa-miR-497-5p	HITS-CLIP	23706177
MIRT682512	hsa-miR-6838-5p	HITS-CLIP	23706177
MIRT682511	hsa-miR-503-5p	HITS-CLIP	23706177
MIRT682510	hsa-miR-646	HITS-CLIP	23706177
MIRT682509	hsa-miR-4310	HITS-CLIP	23706177
MIRT682508	hsa-miR-7157-5p	HITS-CLIP	23706177
MIRT682507	hsa-miR-103a-3p	HITS-CLIP	23706177
MIRT682506	hsa-miR-107	HITS-CLIP	23706177
MIRT682505	hsa-miR-4524a-5p	HITS-CLIP	23706177
MIRT682504	hsa-miR-4524b-5p	HITS-CLIP	23706177
MIRT682503	hsa-miR-4662a-5p	HITS-CLIP	23706177
MIRT682502	hsa-miR-513b-5p	HITS-CLIP	23706177
MIRT629966	hsa-miR-524-3p	HITS-CLIP	23824327
MIRT629965	hsa-miR-525-3p	HITS-CLIP	23824327
MIRT629964	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629963	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT629962	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT629961	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT629960	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT629959	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT629958	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT629957	hsa-miR-7977	HITS-CLIP	23824327
MIRT629956	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629955	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629954	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629953	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT629952	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT629951	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT629950	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT629949	hsa-miR-3689c	HITS-CLIP	23824327
MIRT629948	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT629947	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT629946	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629945	hsa-miR-3122	HITS-CLIP	23824327
MIRT629944	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629943	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629942	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT531905	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531904	hsa-miR-4712-3p	PAR-CLIP	22012620
MIRT531903	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT531902	hsa-miR-548aw	PAR-CLIP	22012620
MIRT531901	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT531900	hsa-miR-527	PAR-CLIP	22012620
MIRT531899	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT450446	hsa-miR-5582-5p	PAR-CLIP	22100165
MIRT450445	hsa-miR-4269	PAR-CLIP	22100165
MIRT450444	hsa-miR-6715b-5p	PAR-CLIP	22100165
MIRT450443	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT450442	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	27292025
MIRT629953	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT629953	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT629962	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT629962	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT629952	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT629952	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT629951	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT629951	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT629950	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT629950	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT629949	hsa-miR-3689c	PAR-CLIP	27292025
MIRT629949	hsa-miR-3689c	PAR-CLIP	27292025
MIRT629961	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT629961	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT629948	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT629948	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT629947	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT629947	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT629960	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT629960	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT629958	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT629958	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT629959	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT629959	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT629963	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT629963	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT696128	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT696127	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT696126	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT696125	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696124	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT696123	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT696122	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696121	hsa-miR-3926	HITS-CLIP	23313552
MIRT696120	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT696119	hsa-miR-548s	HITS-CLIP	23313552
MIRT682518	hsa-miR-15a-5p	HITS-CLIP	23706177
MIRT682517	hsa-miR-15b-5p	HITS-CLIP	23706177
MIRT682516	hsa-miR-16-5p	HITS-CLIP	23706177
MIRT682515	hsa-miR-195-5p	HITS-CLIP	23706177
MIRT682514	hsa-miR-424-5p	HITS-CLIP	23706177
MIRT682513	hsa-miR-497-5p	HITS-CLIP	23706177
MIRT682512	hsa-miR-6838-5p	HITS-CLIP	23706177
MIRT682511	hsa-miR-503-5p	HITS-CLIP	23706177
MIRT682510	hsa-miR-646	HITS-CLIP	23706177
MIRT682509	hsa-miR-4310	HITS-CLIP	23706177
MIRT682508	hsa-miR-7157-5p	HITS-CLIP	23706177
MIRT682507	hsa-miR-103a-3p	HITS-CLIP	23706177
MIRT682506	hsa-miR-107	HITS-CLIP	23706177
MIRT682505	hsa-miR-4524a-5p	HITS-CLIP	23706177
MIRT682504	hsa-miR-4524b-5p	HITS-CLIP	23706177
MIRT682503	hsa-miR-4662a-5p	HITS-CLIP	23706177
MIRT682502	hsa-miR-513b-5p	HITS-CLIP	23706177
MIRT629966	hsa-miR-524-3p	HITS-CLIP	23824327
MIRT629965	hsa-miR-525-3p	HITS-CLIP	23824327
MIRT629964	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629963	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT629962	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT629961	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT629960	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT629959	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT629958	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT629957	hsa-miR-7977	HITS-CLIP	23824327
MIRT629956	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629955	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629954	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629953	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT629952	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT629951	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT629950	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT629949	hsa-miR-3689c	HITS-CLIP	23824327
MIRT629948	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT629947	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT629946	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629945	hsa-miR-3122	HITS-CLIP	23824327
MIRT629944	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629943	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629942	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT531905	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531904	hsa-miR-4712-3p	PAR-CLIP	22012620
MIRT531903	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT531902	hsa-miR-548aw	PAR-CLIP	22012620
MIRT531901	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT531900	hsa-miR-527	PAR-CLIP	22012620
MIRT531899	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT450446	hsa-miR-5582-5p	PAR-CLIP	22100165
MIRT450445	hsa-miR-4269	PAR-CLIP	22100165
MIRT450444	hsa-miR-6715b-5p	PAR-CLIP	22100165
MIRT450443	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT450442	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	22100165

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9990065
GO:0004967	Function	Glucagon receptor activity	IBA
GO:0004967	Function	Glucagon receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9990065
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	9990065
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	9990065
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9990065
GO:0017046	Function	Peptide hormone binding	IBA
GO:0071377	Process	Cellular response to glucagon stimulus	IEA

MIM	HGNC	e!Ensembl
603659	4325	ENSG00000065325

Protein

UniProt ID

O95838

Protein name

Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)

Protein function

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

PDB

7D68

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02793	HRM	93 → 162	Hormone receptor domain	Family
PF00002	7tm_2	175 → 432	7 transmembrane receptor (Secretin family)	Family

Sequence

MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK
LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
ANTMEEILEESEI

Sequence length

553

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Apraxias	Associate	27120335
Colorectal Neoplasms	Associate	21948569, 37076536
Coronary Artery Disease	Associate	33544567
Diabetes Gestational	Associate	36313769
Diabetes Mellitus	Associate	32936762
Diabetes Mellitus Type 2	Associate	28566273, 33414548
Inflammation	Inhibit	34290670
Lung Neoplasms	Associate	35027025
Metabolic Diseases	Associate	32936762
Neoplasms	Inhibit	37076536
Obesity	Associate	32986861

GLP2R (glucagon like peptide 2 receptor)