Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9326
Gene name	Zinc finger HIT-type containing 3
Gene symbol	ZNHIT3
Synonyms (NCBI Gene)	Hit1PEHOTRIP3
Chromosome	17
Chromosome location	17q12

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024305	hsa-miR-215-5p	Microarray	19074876
MIRT026564	hsa-miR-192-5p	Microarray	19074876
MIRT043888	hsa-miR-378a-3p	CLASH	23622248
MIRT449216	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT449214	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT449213	hsa-miR-144-5p	PAR-CLIP	22100165
MIRT449212	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT449211	hsa-miR-573	PAR-CLIP	22100165
MIRT449216	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT449214	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT449213	hsa-miR-144-5p	PAR-CLIP	22100165
MIRT449212	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT449211	hsa-miR-573	PAR-CLIP	22100165
MIRT1542923	hsa-miR-101	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT1542927	hsa-miR-144	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT1542929	hsa-miR-2052	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT1542931	hsa-miR-4477a	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT1542933	hsa-miR-548a-5p	CLIP-seq
MIRT1542934	hsa-miR-548ab	CLIP-seq
MIRT1542935	hsa-miR-548ac	CLIP-seq
MIRT1542936	hsa-miR-548ae	CLIP-seq
MIRT1542937	hsa-miR-548aj	CLIP-seq
MIRT1542938	hsa-miR-548ak	CLIP-seq
MIRT1542939	hsa-miR-548am	CLIP-seq
MIRT1542940	hsa-miR-548b-5p	CLIP-seq
MIRT1542941	hsa-miR-548c-5p	CLIP-seq
MIRT1542942	hsa-miR-548d-3p	CLIP-seq
MIRT1542943	hsa-miR-548d-5p	CLIP-seq
MIRT1542944	hsa-miR-548h	CLIP-seq
MIRT1542945	hsa-miR-548i	CLIP-seq
MIRT1542946	hsa-miR-548j	CLIP-seq
MIRT1542947	hsa-miR-548n	CLIP-seq
MIRT1542948	hsa-miR-548w	CLIP-seq
MIRT1542949	hsa-miR-548x	CLIP-seq
MIRT1542950	hsa-miR-548y	CLIP-seq
MIRT1542951	hsa-miR-548z	CLIP-seq
MIRT1542952	hsa-miR-559	CLIP-seq
MIRT1542953	hsa-miR-936	CLIP-seq
MIRT2163785	hsa-miR-136	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2163788	hsa-miR-3064-3p	CLIP-seq
MIRT2163789	hsa-miR-346	CLIP-seq
MIRT2163790	hsa-miR-3691-3p	CLIP-seq
MIRT2163791	hsa-miR-4477b	CLIP-seq
MIRT2163792	hsa-miR-4715-3p	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2163794	hsa-miR-4768-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT2163785	hsa-miR-136	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT2382979	hsa-miR-15a	CLIP-seq
MIRT2382980	hsa-miR-15b	CLIP-seq
MIRT2382981	hsa-miR-16	CLIP-seq
MIRT2382982	hsa-miR-195	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT2163788	hsa-miR-3064-3p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2163789	hsa-miR-346	CLIP-seq
MIRT2382986	hsa-miR-3647-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2163790	hsa-miR-3691-3p	CLIP-seq
MIRT2382989	hsa-miR-424	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT1542931	hsa-miR-4477a	CLIP-seq
MIRT2163791	hsa-miR-4477b	CLIP-seq
MIRT2163792	hsa-miR-4715-3p	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2382995	hsa-miR-497	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2673489	hsa-miR-3192	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2382986	hsa-miR-3647-5p	CLIP-seq
MIRT2673490	hsa-miR-3663-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2673491	hsa-miR-4314	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT2673492	hsa-miR-4419a	CLIP-seq
MIRT2673493	hsa-miR-4433	CLIP-seq
MIRT2673494	hsa-miR-4484	CLIP-seq
MIRT2673495	hsa-miR-4510	CLIP-seq
MIRT2673496	hsa-miR-4514	CLIP-seq
MIRT2673497	hsa-miR-4527	CLIP-seq
MIRT2673498	hsa-miR-4646-5p	CLIP-seq
MIRT2673499	hsa-miR-4661-5p	CLIP-seq
MIRT2673500	hsa-miR-4690-5p	CLIP-seq
MIRT2673501	hsa-miR-4692	CLIP-seq
MIRT2673502	hsa-miR-4736	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2673503	hsa-miR-548an	CLIP-seq
MIRT1542947	hsa-miR-548n	CLIP-seq
MIRT2673504	hsa-miR-657	CLIP-seq
MIRT2673505	hsa-miR-665	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT2673506	hsa-miR-940	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2673489	hsa-miR-3192	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2673490	hsa-miR-3663-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2673491	hsa-miR-4314	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT2673492	hsa-miR-4419a	CLIP-seq
MIRT2673494	hsa-miR-4484	CLIP-seq
MIRT2673495	hsa-miR-4510	CLIP-seq
MIRT2673496	hsa-miR-4514	CLIP-seq
MIRT2673497	hsa-miR-4527	CLIP-seq
MIRT2673498	hsa-miR-4646-5p	CLIP-seq
MIRT2673499	hsa-miR-4661-5p	CLIP-seq
MIRT2673500	hsa-miR-4690-5p	CLIP-seq
MIRT2673501	hsa-miR-4692	CLIP-seq
MIRT2673502	hsa-miR-4736	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2673503	hsa-miR-548an	CLIP-seq
MIRT2673504	hsa-miR-657	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT2673506	hsa-miR-940	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000492	Process	Box C/D snoRNP assembly	IBA
GO:0005515	Function	Protein binding	IPI	25170085, 28335020, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	28335020
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	28335020
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	7776974
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046966	Function	Nuclear thyroid hormone receptor binding	TAS	7776974
GO:0070761	Component	Pre-snoRNP complex	IBA

MIM	HGNC	e!Ensembl
604500	12309	ENSG00000273611

Q15649

Protein name

Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3)

PDB

2YQQ , 5L85

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04438	zf-HIT	7 → 36	HIT zinc finger	Domain

Sequence

MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTK
TVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQG
EDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Sequence length

155

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
PEHO syndrome	Likely pathogenic	rs148890852	RCV000490627

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Lung cancer	Likely benign	rs377271926	RCV005902915
ZNHIT3-related disorder	Likely benign; Benign	rs746721426, rs140610432, rs112194209	RCV003921509 RCV003979144 RCV003916215

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	28639078
Developmental Disabilities	Associate	35843310
Diabetes Mellitus Type 2	Associate	17656577
Mason Type Diabetes	Associate	17656577
PEHO syndrome	Associate	31048081, 35843310

ZNHIT3 (zinc finger HIT-type containing 3)