PTER (phosphotriesterase related)

Gene

• Entrez ID: 9317
• Gene name: Phosphotriesterase related
• Gene symbol: PTER
• Synonyms (NCBI Gene): HPHRP, RPR-1
• Chromosome: 10
• Chromosome location: 10p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020265	hsa-miR-130b-3p	Sequencing	20371350
MIRT038546	hsa-miR-29c-5p	CLASH	23622248
MIRT1272442	hsa-miR-1185	CLIP-seq
MIRT1272443	hsa-miR-1270	CLIP-seq
MIRT1272444	hsa-miR-128	CLIP-seq
MIRT1272445	hsa-miR-135a	CLIP-seq
MIRT1272446	hsa-miR-135b	CLIP-seq
MIRT1272447	hsa-miR-15a	CLIP-seq
MIRT1272448	hsa-miR-15b	CLIP-seq
MIRT1272449	hsa-miR-16	CLIP-seq
MIRT1272450	hsa-miR-185	CLIP-seq
MIRT1272451	hsa-miR-195	CLIP-seq
MIRT1272452	hsa-miR-2053	CLIP-seq
MIRT1272453	hsa-miR-217	CLIP-seq
MIRT1272454	hsa-miR-3119	CLIP-seq
MIRT1272455	hsa-miR-3158-3p	CLIP-seq
MIRT1272456	hsa-miR-3174	CLIP-seq
MIRT1272457	hsa-miR-3182	CLIP-seq
MIRT1272458	hsa-miR-3605-5p	CLIP-seq
MIRT1272459	hsa-miR-365	CLIP-seq
MIRT1272460	hsa-miR-3651	CLIP-seq
MIRT1272461	hsa-miR-3658	CLIP-seq
MIRT1272462	hsa-miR-3679-5p	CLIP-seq
MIRT1272463	hsa-miR-3682-5p	CLIP-seq
MIRT1272464	hsa-miR-3686	CLIP-seq
MIRT1272465	hsa-miR-3692	CLIP-seq
MIRT1272466	hsa-miR-371b-3p	CLIP-seq
MIRT1272467	hsa-miR-374c	CLIP-seq
MIRT1272468	hsa-miR-3929	CLIP-seq
MIRT1272469	hsa-miR-424	CLIP-seq
MIRT1272470	hsa-miR-4272	CLIP-seq
MIRT1272471	hsa-miR-4275	CLIP-seq
MIRT1272472	hsa-miR-4306	CLIP-seq
MIRT1272473	hsa-miR-4419b	CLIP-seq
MIRT1272474	hsa-miR-4437	CLIP-seq
MIRT1272475	hsa-miR-4446-3p	CLIP-seq
MIRT1272476	hsa-miR-4452	CLIP-seq
MIRT1272477	hsa-miR-4478	CLIP-seq
MIRT1272478	hsa-miR-4494	CLIP-seq
MIRT1272479	hsa-miR-4504	CLIP-seq
MIRT1272480	hsa-miR-4519	CLIP-seq
MIRT1272481	hsa-miR-4531	CLIP-seq
MIRT1272482	hsa-miR-4641	CLIP-seq
MIRT1272483	hsa-miR-4644	CLIP-seq
MIRT1272484	hsa-miR-4677-3p	CLIP-seq
MIRT1272485	hsa-miR-4679	CLIP-seq
MIRT1272486	hsa-miR-4687-3p	CLIP-seq
MIRT1272487	hsa-miR-4698	CLIP-seq
MIRT1272488	hsa-miR-4742-3p	CLIP-seq
MIRT1272489	hsa-miR-4753-3p	CLIP-seq
MIRT1272490	hsa-miR-4764-3p	CLIP-seq
MIRT1272491	hsa-miR-4778-5p	CLIP-seq
MIRT1272492	hsa-miR-497	CLIP-seq
MIRT1272493	hsa-miR-500a	CLIP-seq
MIRT1272494	hsa-miR-501-5p	CLIP-seq
MIRT1272495	hsa-miR-542-3p	CLIP-seq
MIRT1272496	hsa-miR-569	CLIP-seq
MIRT1272497	hsa-miR-617	CLIP-seq
MIRT1272498	hsa-miR-620	CLIP-seq
MIRT1272499	hsa-miR-655	CLIP-seq
MIRT1272500	hsa-miR-921	CLIP-seq
MIRT1272501	hsa-miR-938	CLIP-seq
MIRT1272502	hsa-miR-942	CLIP-seq
MIRT1272503	hsa-miR-1257	CLIP-seq
MIRT1272504	hsa-miR-1297	CLIP-seq
MIRT1272505	hsa-miR-1301	CLIP-seq
MIRT1272506	hsa-miR-130a	CLIP-seq
MIRT1272507	hsa-miR-130b	CLIP-seq
MIRT1272508	hsa-miR-1321	CLIP-seq
MIRT1272509	hsa-miR-154	CLIP-seq
MIRT1272510	hsa-miR-204	CLIP-seq
MIRT1272511	hsa-miR-211	CLIP-seq
MIRT1272512	hsa-miR-2110	CLIP-seq
MIRT1272513	hsa-miR-2116	CLIP-seq
MIRT1272514	hsa-miR-2117	CLIP-seq
MIRT1272515	hsa-miR-214	CLIP-seq
MIRT1272516	hsa-miR-2276	CLIP-seq
MIRT1272517	hsa-miR-26a	CLIP-seq
MIRT1272518	hsa-miR-26b	CLIP-seq
MIRT1272519	hsa-miR-298	CLIP-seq
MIRT1272520	hsa-miR-300	CLIP-seq
MIRT1272521	hsa-miR-301a	CLIP-seq
MIRT1272522	hsa-miR-301b	CLIP-seq
MIRT1272523	hsa-miR-3148	CLIP-seq
MIRT1272524	hsa-miR-3150a-3p	CLIP-seq
MIRT1272525	hsa-miR-3162-5p	CLIP-seq
MIRT1272526	hsa-miR-323b-3p	CLIP-seq
MIRT1272527	hsa-miR-329	CLIP-seq
MIRT1272528	hsa-miR-3619-5p	CLIP-seq
MIRT1272529	hsa-miR-362-3p	CLIP-seq
MIRT1272461	hsa-miR-3658	CLIP-seq
MIRT1272530	hsa-miR-3659	CLIP-seq
MIRT1272531	hsa-miR-3666	CLIP-seq
MIRT1272532	hsa-miR-3678-3p	CLIP-seq
MIRT1272533	hsa-miR-371-5p	CLIP-seq
MIRT1272534	hsa-miR-371b-5p	CLIP-seq
MIRT1272535	hsa-miR-374a	CLIP-seq
MIRT1272536	hsa-miR-374b	CLIP-seq
MIRT1272537	hsa-miR-381	CLIP-seq
MIRT1272538	hsa-miR-383	CLIP-seq
MIRT1272539	hsa-miR-3941	CLIP-seq
MIRT1272540	hsa-miR-3944-5p	CLIP-seq
MIRT1272541	hsa-miR-425	CLIP-seq
MIRT1272542	hsa-miR-4260	CLIP-seq
MIRT1272543	hsa-miR-4271	CLIP-seq
MIRT1272544	hsa-miR-4273	CLIP-seq
MIRT1272545	hsa-miR-4278	CLIP-seq
MIRT1272546	hsa-miR-4282	CLIP-seq
MIRT1272547	hsa-miR-4291	CLIP-seq
MIRT1272548	hsa-miR-4295	CLIP-seq
MIRT1272476	hsa-miR-4452	CLIP-seq
MIRT1272549	hsa-miR-4465	CLIP-seq
MIRT1272550	hsa-miR-454	CLIP-seq
MIRT1272551	hsa-miR-4652-3p	CLIP-seq
MIRT1272552	hsa-miR-4660	CLIP-seq
MIRT1272553	hsa-miR-4666-3p	CLIP-seq
MIRT1272554	hsa-miR-4668-5p	CLIP-seq
MIRT1272555	hsa-miR-4671-3p	CLIP-seq
MIRT1272556	hsa-miR-4672	CLIP-seq
MIRT1272557	hsa-miR-4677-5p	CLIP-seq
MIRT1272558	hsa-miR-4684-3p	CLIP-seq
MIRT1272487	hsa-miR-4698	CLIP-seq
MIRT1272559	hsa-miR-4719	CLIP-seq
MIRT1272560	hsa-miR-4725-3p	CLIP-seq
MIRT1272561	hsa-miR-4739	CLIP-seq
MIRT1272489	hsa-miR-4753-3p	CLIP-seq
MIRT1272562	hsa-miR-4755-5p	CLIP-seq
MIRT1272563	hsa-miR-4756-5p	CLIP-seq
MIRT1272564	hsa-miR-4761-5p	CLIP-seq
MIRT1272565	hsa-miR-4772-3p	CLIP-seq
MIRT1272566	hsa-miR-4772-5p	CLIP-seq
MIRT1272567	hsa-miR-4780	CLIP-seq
MIRT1272568	hsa-miR-4789-5p	CLIP-seq
MIRT1272569	hsa-miR-4797-5p	CLIP-seq
MIRT1272570	hsa-miR-5047	CLIP-seq
MIRT1272571	hsa-miR-544b	CLIP-seq
MIRT1272572	hsa-miR-549	CLIP-seq
MIRT1272573	hsa-miR-582-5p	CLIP-seq
MIRT1272574	hsa-miR-603	CLIP-seq
MIRT1272497	hsa-miR-617	CLIP-seq
MIRT1272575	hsa-miR-623	CLIP-seq
MIRT1272576	hsa-miR-663b	CLIP-seq
MIRT1272577	hsa-miR-759	CLIP-seq
MIRT1272578	hsa-miR-761	CLIP-seq
MIRT1272579	hsa-miR-888	CLIP-seq
MIRT1272580	hsa-miR-922	CLIP-seq
MIRT1272502	hsa-miR-942	CLIP-seq
MIRT1272581	hsa-miR-944	CLIP-seq
MIRT1552674	hsa-miR-2054	CLIP-seq
MIRT1272504	hsa-miR-1297	CLIP-seq
MIRT2080138	hsa-miR-203	CLIP-seq
MIRT1272517	hsa-miR-26a	CLIP-seq
MIRT1272518	hsa-miR-26b	CLIP-seq
MIRT1272463	hsa-miR-3682-5p	CLIP-seq
MIRT2080139	hsa-miR-4289	CLIP-seq
MIRT1272549	hsa-miR-4465	CLIP-seq
MIRT1272489	hsa-miR-4753-3p	CLIP-seq
MIRT2080140	hsa-miR-4773	CLIP-seq
MIRT2080141	hsa-miR-548p	CLIP-seq
MIRT2080142	hsa-miR-616	CLIP-seq
MIRT2080143	hsa-miR-664	CLIP-seq
MIRT2306413	hsa-miR-889	CLIP-seq
MIRT1272443	hsa-miR-1270	CLIP-seq
MIRT1272504	hsa-miR-1297	CLIP-seq
MIRT1272517	hsa-miR-26a	CLIP-seq
MIRT1272518	hsa-miR-26b	CLIP-seq
MIRT1272546	hsa-miR-4282	CLIP-seq
MIRT2306414	hsa-miR-4434	CLIP-seq
MIRT1272549	hsa-miR-4465	CLIP-seq
MIRT2306415	hsa-miR-4516	CLIP-seq
MIRT1272481	hsa-miR-4531	CLIP-seq
MIRT1272487	hsa-miR-4698	CLIP-seq
MIRT2080142	hsa-miR-616	CLIP-seq
MIRT1272498	hsa-miR-620	CLIP-seq
MIRT2306416	hsa-miR-885-3p	CLIP-seq
MIRT1272503	hsa-miR-1257	CLIP-seq
MIRT1272564	hsa-miR-4761-5p	CLIP-seq
MIRT1272579	hsa-miR-888	CLIP-seq
MIRT2457398	hsa-miR-548c-3p	CLIP-seq
MIRT2603725	hsa-miR-433	CLIP-seq
MIRT1272489	hsa-miR-4753-3p	CLIP-seq
MIRT2080140	hsa-miR-4773	CLIP-seq
MIRT2603726	hsa-miR-548ac	CLIP-seq
MIRT2603727	hsa-miR-548ae	CLIP-seq
MIRT2603728	hsa-miR-548aj	CLIP-seq
MIRT2603729	hsa-miR-548am	CLIP-seq
MIRT2457398	hsa-miR-548c-3p	CLIP-seq
MIRT2603730	hsa-miR-548d-3p	CLIP-seq
MIRT2603731	hsa-miR-548x	CLIP-seq
MIRT2603732	hsa-miR-548z	CLIP-seq
MIRT2688899	hsa-miR-101	CLIP-seq
MIRT1272443	hsa-miR-1270	CLIP-seq
MIRT2688900	hsa-miR-144	CLIP-seq
MIRT1272450	hsa-miR-185	CLIP-seq
MIRT1272467	hsa-miR-374c	CLIP-seq
MIRT1272472	hsa-miR-4306	CLIP-seq
MIRT2603725	hsa-miR-433	CLIP-seq
MIRT1272481	hsa-miR-4531	CLIP-seq
MIRT1272483	hsa-miR-4644	CLIP-seq
MIRT2688901	hsa-miR-4645-3p	CLIP-seq
MIRT1272489	hsa-miR-4753-3p	CLIP-seq
MIRT2080140	hsa-miR-4773	CLIP-seq
MIRT1272493	hsa-miR-500a	CLIP-seq
MIRT1272494	hsa-miR-501-5p	CLIP-seq
MIRT2603726	hsa-miR-548ac	CLIP-seq
MIRT2603727	hsa-miR-548ae	CLIP-seq
MIRT2603728	hsa-miR-548aj	CLIP-seq
MIRT2603729	hsa-miR-548am	CLIP-seq
MIRT2603730	hsa-miR-548d-3p	CLIP-seq
MIRT2603731	hsa-miR-548x	CLIP-seq
MIRT2603732	hsa-miR-548z	CLIP-seq
MIRT1272574	hsa-miR-603	CLIP-seq
MIRT1272498	hsa-miR-620	CLIP-seq
MIRT1272499	hsa-miR-655	CLIP-seq
MIRT2688902	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0019530	Process	Taurine metabolic process	IDA	39112712
GO:0019530	Process	Taurine metabolic process	IEA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0032098	Process	Regulation of appetite	IEA
GO:0032098	Process	Regulation of appetite	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0141215	Function	N-acetyltaurine hydrolase activity	IDA	39112712
GO:0141215	Function	N-acetyltaurine hydrolase activity	IEA

Other IDs

• MIM: 604446
• HGNC: 9590
• e!Ensembl: ENSG00000165983

Protein

• UniProt ID: Q96BW5
• Protein name: N-acetyltaurine hydrolase (EC 3.1.-.-) (Phosphotriesterase-related protein)
• Protein function: N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate (PubMed:39112712). N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02126	PTE	15 → 347	Phosphotriesterase family	Domain

• Sequence:

  MSSLSGKVQTVLGLVEPSKLGRTLTHEHLAMTFDCCYCPPPPCQEAISKEPIVMKNLYWI
  QKNAYSHKENLQLNQETEAIKEELLYFKANGGGALVENTTTGISRDTQTLKRLAEETGVH
  IISGAGFYVDATHSSETRAMSVEQLTDVLMNEILHGADGTSIKCGIIGEIGCSWPLTESE
  RKVLQATAHAQAQLGCPVIIHPGRSSRAPFQIIRILQEAGADISKTVMSHLDRTILDKKE
  LLEFAQLGCYLEYDLFGTELLHYQLGPDIDMPDDNKRIRRVRLLVEEGCEDRILVAHDIH
  TKTRLMKYGGHGYSHILTNVVPKMLLRGITENVLDKILIENPKQWLTFK

• Sequence length: 349

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs34728849	RCV005908065
Cervical cancer	Benign	rs34728849	RCV005908068
Clear cell carcinoma of kidney	Benign	rs34728849	RCV005908069
Gastric cancer	Benign	rs34728849	RCV005908071
Hepatocellular carcinoma	Benign	rs34728849	RCV005908066
Lung cancer	Benign	rs34728849	RCV005908074
Nonpapillary renal cell carcinoma	Benign	rs34728849	RCV005908067
Ovarian serous cystadenocarcinoma	Benign	rs34728849	RCV005908072
Sarcoma	Benign	rs34728849	RCV005908070
Thyroid cancer, nonmedullary, 1	Benign	rs34728849	RCV005908073
Uterine corpus endometrial carcinoma	Benign	rs34728849	RCV005908075

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Stimulate	37699602
COVID 19	Associate	36052061
Obesity	Associate	23950976